Results 91 to 100 of about 5,434 (195)

Novel BRD2::NUTM1 Fusion in NUT Carcinoma With Exceptional Response to Chemotherapy: A Case Report

JTO Clinical and Research Reports
We present the first known case of a patient with BRD2::NUTM1-driven NUT carcinoma. A 59-year-old woman presented with poorly differentiated squamous cell lung cancer metastatic to the pleura.
Sarah J. Wu, MD, PhD, Justin J. Kim, Yeying Huang, BS, R. Taylor Durall, BS, Simone Becker, RN, Stephanie Canty, CNP, MSN, Stefania Molinaro, BS, Evan Pisick, MD, Geoffrey I. Shapiro, MD, PhD, Christopher A. French, MD, Jia Luo, MD   +10 more
doaj   +1 more source

Functional Analysis of the Replication Fork Proteome Identifies BET Proteins as PCNA Regulators

Cell Reports, 2019
Summary: Identifying proteins that function at replication forks is essential to understanding DNA replication, chromatin assembly, and replication-coupled DNA repair mechanisms.
Sarah R. Wessel, Kareem N. Mohni, Jessica W. Luzwick, Huzefa Dungrawala, David Cortez   +4 more
doaj   +1 more source

Identification and Mechanisms of Osteocyte Subsets Involved in the Pathological Progression of Osteoporosis

Advanced Science, Volume 13, Issue 5, 27 January 2026.
Osteocyte heterogeneity in bone remains poorly understood. This study identifies six distinct osteocyte subsets in mice, revealing a key subpopulation (BHR‐Ocys) that drives bone loss in osteoporosis. BHR‐Ocys promote osteoclast‐mediated resorption via a novel Sema5a‐Plxna1 signaling axis.
Zengxin Jiang, Biyu Rui, Xuecheng He, Jiajun Wang, Xiangdong Wu, Rui Shao, Xue Meng, Xiaochun Peng, Hengfeng Yuan   +8 more
wiley   +1 more source

Glioblastoma Mesenchymal Transition and Invasion are Dependent on a NF-κB/BRD2 Chromatin Complex

, 2023
Abstract Glioblastoma (GBM) represents the most aggressive subtype of glioma, noted for its profound invasiveness and molecular heterogeneity. The mesenchymal (MES) transcriptomic subtype is frequently associated with therapy resistance, rapid recurrence, and increased tumor-associated macrophages. Notably, activation
Raghavendra Vadla, Shunichiro Miki, Brett Taylor, Daisuke Kawauchi, Brandon M Jones, Nidhi Nathwani, Philip Pham, Jonathan Tsang, David A. Nathanson, Frank B. Furnari   +9 more
openaire   +2 more sources

The major histocompatibility complex (Mhc) class IIB region has greater genomic structural flexibility and diversity in the quail than the chicken

BMC Genomics, 2006
Background The quail and chicken major histocompatibility complex (Mhc) genomic regions have a similar overall organization but differ markedly in that the quail has an expanded number of duplicated class I, class IIB, natural killer (NK)-receptor-like ...
Kulski Jerzy K, Yoshida Yutaka, Hara Hiromi, Iwamoto Shigehisa, Shimizu Sayoko, Tanaka Masayuki, Suzuki Shingo, Shiina Takashi, Hosomichi Kazuyoshi, Inoko Hidetoshi, Hanzawa Kei   +10 more
doaj   +1 more source

Susceptibility of Brd2 heterozygous KO mice (+/-) and control littermates (+/+) to flurothyl-induced seizures.

, 2013
Seizure threshold is depicted in µl of flurothyl necessary to induce specific seizure type (Mean±S.E.M.). (A) In females, tonic-clonic seizures in Brd2+/- mice had significantly lower threshold than in Brd2+/+ littermate controls.
Jana Velíšková (5423975), Stephania Macchiarulo (345520), David A. Greenberg (319010), Giorgi Maglakelidze (345522), Debra J. Wolgemuth (124823), Enyuan Shang (345517), Tamar Chachua (345519), Libor Velíšek (345515)   +7 more
core   +1 more source

BRD2 impedes iPSC reprogramming by regulating lipogenesis and matrisome

Abstract Induction of human pluripotent stem cells (HiPSCs) from somatic cells encounters significant barriers, which remain poorly understood. Lipids are fundamental cellular molecules with many essential roles. However, lipid roles in reprogramming are unknown.
Kejin Hu, Ricardo Cevallos, Ruowen Zhang, Shu Chen   +3 more
openaire   +2 more sources

YEATS domain-containing protein GAS41 regulates nuclear shape by working in concert with BRD2 and the mediator complex in colorectal cancer

Pharmacological Research
The maintenance of nuclear shape is essential for cellular homeostasis and disruptions in this process have been linked to various pathological conditions, including cancer, laminopathies, and aging. Despite the significance of nuclear shape, the precise
Zhengmin Wang, Nan Zhao, Siwei Zhang, Deyu Wang, Shuai Wang, Nan Liu   +5 more
doaj   +1 more source

Brd4 is essential for IL-1β-induced inflammation in human airway epithelial cells.

PLoS ONE, 2014
BackgroundChronic inflammation and oxidative stress are key features of chronic obstructive pulmonary disease (COPD). Oxidative stress enhances COPD inflammation under the control of the pro-inflammatory redox-sensitive transcription factor nuclear ...
Younis M Khan, Paul Kirkham, Peter J Barnes, Ian M Adcock   +3 more
doaj   +1 more source

Anàlisi del contingut de RNA i estudi mutacional de gens candidats en iinfertilitat masculina [PDF]

, 2012
[cat]La infertilitat és un problema que cada cop és més comú en la població actual. S’ha definit que la meitat dels casos de la infertilitat es deu a un factor masculí, no obstant, la gran majoria segueix sent d’etiologia desconeguda. Els grans objectius
Jodar Bifet, Meritxell
core