Results 101 to 110 of about 5,434 (195)

Single cell analysis of transcriptional activation dynamics.

PLoS ONE, 2010
BackgroundGene activation is thought to occur through a series of temporally defined regulatory steps. However, this process has not been completely evaluated in single living mammalian cells.Methodology/principal findingsTo investigate the timing and ...
Ilona U Rafalska-Metcalf, Sara Lawrence Powers, Lucy M Joo, Gary LeRoy, Susan M Janicki   +4 more
doaj   +1 more source

BRD2 bridges TFIID and histone acetylation to promote transcriptional initiation

Abstract Members of the bromodomain and extraterminal domain (BET) protein family play a central role in transcription by RNA Polymerase II (Pol II). Small-molecule inhibitors that block interaction between BET bromodomains and acetylated histones have been developed to achieve therapeutic benefit. However, the BET protein BRD4 does not
Zheng, Bin, Qiu, Ruxuan, Gold, Sarah, Iwanaszko, Marta, Aoi, Yuki, Howard, Benjamin Charles, Das, Madhurima, Shilatifard, Ali   +7 more
openaire   +3 more sources

The Role of Bromodomain Testis-Specific Factor, BRDT, in Cancer: A Biomarker and A Possible Therapeutic Target

Cell Journal, 2017
Cancer cells have recently been shown to activate hundreds of normally silent tissue-restricted genes, including a specific subset associated with cancer progression and poor prognosis.
Ekaterina Flin, Florent Chuffart, Sophie Rousseaux, Saadi Khochbin   +3 more
doaj   +1 more source

BRD2 Phase Separation Promotes Ferritinophagy in Depression

Abstract Background Depression is a psychiatric disorder which affects many aspects of social life of patients; however, the molecular biological mechanisms underlying its development are not fully understood.
Zhen Li, Xiaoling Wang, Qinglian Li, Yangping Liu, Wenwen Si, Dongfeng Chen, Qizhang Wang, Meiling Zhu   +7 more
openaire   +1 more source

Additional elements of the H2A.Z nucleosome contribute to the interaction with Brd2.

, 2012
A. Schematic workflow of nucleosome preparation used to randomly re-assemble H2A–H2B and H2A.Z-H2B dimers with H3–H4 tetramers, generating H2A- and H2A.Z-nucleosomes with comparable levels of H3 and H4 PTMs. B.
Ryan Draker (121524), Peter Cheung (121536), Thomas Kislinger (121533), Elizabeth Sarcinella (121530), Marlee K. Ng (121527), Vladimir Ignatchenko (121532)   +5 more
core   +1 more source

BRD4 bimodal binding at promoters and drug-induced displacement at Pol II pause sites associates with I-BET sensitivity

Epigenetics & Chromatin, 2019
Background Deregulated transcription is a major driver of diseases such as cancer. Bromodomain and extra-terminal (BET) proteins (BRD2, BRD3, BRD4 and BRDT) are chromatin readers essential for maintaining proper gene transcription by specifically binding
P. Khoueiry, A. Ward Gahlawat, M. Petretich, A. M. Michon, D. Simola, E. Lam, E. E. Furlong, V. Benes, M. A. Dawson, R. K. Prinjha, G. Drewes, P. Grandi   +11 more
doaj   +1 more source

Crystal Structure of the Human BRD2 Bromodomain [PDF]

Journal of Biological Chemistry, 2007
Yoshihiro Nakamura, Takashi Umehara, Kazumi Nakano, Moon Kyoo Jang, Mikako Shirouzu, Satoshi Morita, Hiroko Uda-Tochio, Hiroaki Hamana, Takaho Terada, Naruhiko Adachi, Takehisa Matsumoto, Akiko Tanaka, Masami Horikoshi, Keiko Ozato, Balasundaram Padmanabhan, Shigeyuki Yokoyama   +15 more
openaire   +1 more source

The C-terminal domain of Brd2 is important for chromatin interaction and regulation of transcription and alternative splicing.

, 2013
Brd2 is a member of the bromodomain extra terminal (BET) protein family, which consists of four chromatin-interacting proteins that regulate gene expression.
Stanek, D., Humpolicková, J., Hof, M., Hnilicová, J., Stejskalová, E., Poser, I., Dušková, E., Hozeifi, S.   +7 more
core  

A structural basis for BRD2/4-mediated host chromatin interaction and oligomer assembly of Kaposi sarcoma-associated herpesvirus and murine gammaherpesvirus LANA proteins.

PLoS Pathogens, 2013
Kaposi sarcoma-associated herpesvirus (KSHV) establishes a lifelong latent infection and causes several malignancies in humans. Murine herpesvirus 68 (MHV-68) is a related γ2-herpesvirus frequently used as a model to study the biology of γ-herpesviruses ...
Jan Hellert, Magdalena Weidner-Glunde, Joern Krausze, Ulrike Richter, Heiko Adler, Roman Fedorov, Marcel Pietrek, Jessica Rückert, Christiane Ritter, Thomas F Schulz, Thorsten Lührs   +10 more
doaj   +1 more source

H2A.Z influences H4 acetylation and Brd2 recruitment at AR–regulated genes.

, 2012
A. Western blot analyses of whole-cell lysates from LNCaP cells stably expressing either a scrambled control shRNA or an shRNA targeting H2A.Z-1 mRNA.
Ryan Draker (121524), Peter Cheung (121536), Thomas Kislinger (121533), Elizabeth Sarcinella (121530), Marlee K. Ng (121527), Vladimir Ignatchenko (121532)   +5 more
core   +1 more source