Función de las interacciones de las proteínas con bromodominios BRD2 Y BRD4 con las proteínas LYAR Y NIPBL [PDF]
, 2019 Las proteínas BET (Bromodomain and Extra Terminaldomain) constituyen una familia de proteínas compuesta por los miembros Brd2, Brd3, Brd4 (expresados ubicuamente) y Brdt (exclusivo de la línea germinal masculina).
Luna Peláez, Noelia
core
Targeting BRD2 and BRD4 inhibit the growth of KSHV-infected immortalized endothelial cells through suppression of LANA translation. [PDF]
PLoS PathogChen J +6 more
europepmc +1 more source
Bromodomain containing 2 (BRD2); BRD3; BRD4 [PDF]
Science-Business eXchange, 2010 openaire +1 more source
Decreased expression of Ly-1 antibody reactive clone (Lyar) triggers enhanced adipogenesis of bone marrow mesenchymal stromal cells in aged bone marrow. [PDF]
PLoS OneShinyashiki Y +6 more
europepmc +1 more source
Bromodomain containing 4 (BRD4); BRD2; BRD3 [PDF]
Science-Business eXchange, 2014 openaire +1 more source
Brd2 Gene Disruption Causes “Metabolically Healthy” Obesity [PDF]
, 2013 Fangnian Wang +2 more
openaire +1 more source
BRD2 bromodomain-mediated regulation of cell state plasticity modulates therapy response in glioblastoma. [PDF]
Neuro OncolVadla R +16 more
europepmc +1 more source
Deep learning-guided discovery of selective JAK2-JH2 allosteric inhibitors: integration of MLP predictive modeling, BREED-based library design, and computational validation. [PDF]
Front ChemOuassaf M +4 more
europepmc +1 more source
Caractérisation fonctionnelle et structurale de BRD2
Phosphorylation is a key mechanism regulating protein functions, particularly for members of the BET protein family. However, the impact of phospho-dependent modifications on the structure and activity of these proteins remains incompletely understood in the scientific literature.
openaire +1 more source