Results 111 to 120 of about 5,434 (195)
BRD2 upregulation as a pan-cancer adaptive resistance mechanism to BET inhibition
Abstract Bromodomain and extraterminal motif (BET) inhibitors, such as JQ1, are promising cancer therapeutics that target epigenetic regulators, particularly BRD4. However, resistance to BET inhibitors (BETi) limits their clinical utility, necessitating a better understanding of adaptive mechanisms. We identified BRD2
Suyakarn Archasappawat +3 more
openaire +2 more sources
RHV-GMPs recruit BRD2 and BRD4 to the site of chromatin remodeling.
, 2013 Representative confocal images illustrating the nuclear fluorescence of A03-1 cells co-transfected with plasmids expressing mCherry-LacR-VP16 or mCherry-LacR-GMP fusion proteins and YFP-tagged BRD2 or BRD4. The recruitment of BRD2 and BRD4 to the site of
Nouman Mughal (410234) +4 more
core +1 more source
, 2019 Interleukin-17A (IL17A) plays a critical role in the development of numerous autoimmune diseases, including psoriasis. The clinical success of IL17A neutralizing biologics in psoriasis has underlined its importance as a drug discovery target.
Anthony Slavin +41 more
core +1 more source
Investigation of spinal bone morphology during aging in genetically obese heterozygous BrD2 mice compared to C57/B6J mice [PDF]
, 2013 Thesis (M.A.)--Boston UniversityOsteoporosis is a metabolic disease that affects individuals by causing bone quality to ultimately decrease, and therefore, makes these individuals more susceptible to fractures.
Diviney, Patrick
core
BRD2 and TAP-1 genes and juvenile myoclonic epilepsy [PDF]
, 2018 Juvenile myoclonic epilepsy (JME) is a genetically determined common subtype of idiopathic generalized epilepsy. Linkage of JME to the chromosomal region 6p21.3 has been reported. An association has been previously observed between JME and the positional
Layouni, Samia +4 more
core
, 2011 Copyright information:Taken from "Solution structure of the second bromodomain of Brd2 and its specific interaction with acetylated histone tails"http://www.biomedcentral.com/1472-6807/7/57BMC Structural Biology 2007;7():57-57.Published online 12 Sep ...
Weiqun Shen (63884) +6 more
core +1 more source
638 Deciphering the mechanism of the BET protein BRD2 in melanoma [PDF]
Journal of Investigative Dermatology, 2016 M. Gantz, C. Vardabasso, E. Bernstein
openaire +1 more source
, 2012 Les rétrovirus sont des virus à ARN enveloppés dont le génome est converti en un ADN double brin au cours du cycle viral. Cet ADNc est inséré dans le génome de la cellule infectée par une enzyme virale : l’intégrase (IN).
Gallay, Kathy
core +2 more sources