Results 181 to 190 of about 5,434 (195)

Phosphocreatine Promotes Epigenetic Reprogramming to Facilitate Glioblastoma Growth Through Stabilizing BRD2

Cancer Discovery
Abstract Glioblastoma (GBM) exhibits profound metabolic plasticity for survival and therapeutic resistance, while the underlying mechanisms remain unclear. Here, we show that GBM stem cells reprogram the epigenetic landscape by producing substantial amounts of phosphocreatine (PCr).
Lishu Chen, Qinghui Qi, Xiaoqing Jiang, Jin Wu, Yuanyuan Li, Zhaodan Liu, Yan Cai, Haowen Ran, Songyang Zhang, Cheng Zhang, Huiran Wu, Shuailiang Cao, Lanjuan Mi, Dake Xiao, Haohao Huang, Shuai Jiang, Jiaqi Wu, Bohan Li, Jiong Xie, Ji Qi, Fangye Li, Panpan Liang, Qiuying Han, Min Wu, Wenchao Zhou, Chenhui Wang, Weina Zhang, Xin Jiang, Kun Zhang, Huiyan Li, Xuemin Zhang, Ailing Li, Tao Zhou, Jianghong Man   +33 more
openaire   +2 more sources

Acetylation-dependent clustering of BRD2 instructs transcription dynamics

BET protein inhibitors represent one of the most prominent classes of epigenetic drugs. However, the specific contributions of individual BET family members to transcription regulation remain largely unknown. Here, by acutely co-depleting BET proteins, we uncover an essential role of BRD2 in maintaining RNA Polymerase II recruitment at promoters, which
Niyazi Umut Erdogdu, Sukanya Guhathakurta, Maria Shvedunova, Ronald Oellers, Eric Patrick, Jose Alberto Morin Lantero, Janine Seyfferth, Ward Deboutte, Ibrahim Cisse, Asifa Akhtar   +9 more
openaire   +1 more source

BRD2 bridges TFIID and MOF-H4K16ac-containing nucleosomes to promote transcriptional initiation

Molecular Cell
Members of the bromodomain and extraterminal domain (BET) protein family play a central role in transcription by RNA polymerase II (RNA Pol II). Small-molecule inhibitors that block interaction between BET bromodomains and acetylated histones have been developed for disease therapeutics.
Bin, Zheng, Ruxuan, Qiu, Sarah, Gold, Marta, Iwanaszko, Yuki, Aoi, Benjamin Charles, Howard, Madhurima, Das, Ali, Shilatifard   +7 more
openaire   +2 more sources

The Brd2 mouse model of juvenile myoclonic epilepsy (JME)

2023
David A. Greenberg, Libor Velíšek
openaire   +1 more source

Association Analysis of BRD2 (RING3) and Epilepsy in a Dutch Population

Epilepsia, 2007
Carolien G F, de Kovel, Dalila, Pinto, Gerrit J, de Haan, Dorothée G, Kasteleijn-Nolst Trenité, Dick, Lindhout, Bobby P C, Koeleman   +5 more
openaire   +2 more sources

Structural investigation of a pyrano-1,3-oxazine derivative and the phenanthridinone core moiety against BRD2 bromodomains

Acta Crystallographica Section F, Structural Biology Communications, 2022
Aishwarya H Arole, Prashant Deshmukh, Balasundaram Padmanabhan   +2 more
exaly  

Discovery of novel small molecule induced selective degradation of the bromodomain and extra-terminal (BET) bromodomain protein BRD4 and BRD2 with cellular potencies

Bioorganic and Medicinal Chemistry, 2020
Fei Jiang, Hongmei Li, Peng Cao
exaly  

Brd2 is a TBP-associated protein and recruits TBP into E2F-1 transcriptional complex in response to serum stimulation

Molecular and Cellular Biochemistry, 2006
Yipeng Qi, Yingle Liu, Zou Tingting
exaly  

BRD2 is one of BRD7-interacting proteins and its over-expression could initiate apoptosis

Molecular and Cellular Biochemistry, 2006
Ming Zhou, Xiao-Jie Xu, Hou-De Zhou
exaly  

DNA methylation of the BRD2 promoter is associated with juvenile myoclonic epilepsy in Caucasians

Epilepsia, 2018
Shilpa Pathak, William C L Stewart, David A Greenberg   +2 more
exaly