Results 161 to 170 of about 5,434 (195)

Niche-specific epigenetic interventions in the spatially heterogeneous glioblastoma microenvironmental landscape: strategies for radiotherapy enhancement. [PDF]

Front Mol Biosci
Wang J, Li K, Wang Y, Zhang J, Peng X, Ji N.   +5 more
europepmc   +1 more source

Modulation of Bromo- and Extra-Terminal Domain (BET) Proteins Exerts Neuroprotective Effects in Cell Culture Models of Parkinson's Disease. [PDF]

Biomedicines
Martella N, Pensabene D, Colardo M, Muzzi M, Bisesto E, Varone M, Caretti G, Di Porzio A, Barrella V, Mazzoli A, Di Bartolomeo S, Moreno S, Segatto M.   +12 more
europepmc   +1 more source

Unraveling the layers of epigenetic control in respiratory antiviral defense. [PDF]

J Virol
McFadden MI, Simo B, Forero A.
europepmc   +1 more source

Identification of novel therapeutic targets for diabetic neuropathy through integrated proteomics and transcriptomics approaches. [PDF]

World J Diabetes
Ding XF, Dang X, Lin S.
europepmc   +1 more source

Structural Basis for BD1-Preferring 2,4-Disubstituted Pyrimidine BRDT Inhibitors. [PDF]

J Med Chem
Liang T, Guan X, Chan A, Kalra P, Shi R, Solberg J, Sigua LH, Qi J, Pomerantz WCK, Schönbrunn E, Hawkinson JE, Georg GI.   +11 more
europepmc   +1 more source

Helicobacter Pylori-induced BRD2 m⁶A modification sensitizes gastric cancer cells to chemotherapy by breaking FLIP/Caspase-8 homeostasis. [PDF]

Int J Biol Sci
Wang S, Xuan Z, Chen Z, Xu P, Fang L, Li Z, Zhang Y, Liu H, Wang L, Zhang D, Xu H, Yang L, Xu Z.   +12 more
europepmc   +1 more source

Punicalagin with anti-inflammatory activities affects Brd-4 mediated chromatin remodeling for attenuating inflammatory osteolysis. [PDF]

Sci Rep
Li H, Li Q, Wan T, Wang Y, Zhang S.
europepmc   +1 more source

Harnessing FBXO31 with Terminal Amide-Functionalized Molecules for Targeted Protein Degradation. [PDF]

J Am Chem Soc
Zhang C, Jin X, Zhou C, Jenkins MJ, Riha IA, Zhang X.   +5 more
europepmc   +1 more source

Exploring ischemic stroke based on the ferroptosis perspective: ECH1 may serve as a new biomarker and therapeutic target. [PDF]

Front Neurosci
Qu R, Zhang Y, Zhang H, Li K, Zhang B, Tong H, Lu T.   +6 more
europepmc   +1 more source

BRD2 compartmentalizes the accessible genome [PDF]

Nature Genetics, 2022
Mammalian chromosomes are organized into megabase-sized compartments that are further subdivided into topologically associating domains (TADs). While the formation of TADs is dependent on cohesin, the mechanism behind compartmentalization remains enigmatic. Here, we show that the bromodomain and extraterminal (BET) family scaffold protein BRD2 promotes
Liangqi Xie, Peng Dong, Yifeng Qi
exaly   +6 more sources