Results 151 to 160 of about 5,434 (195)

Challenges and opportunities for oncology drug repurposing informed by synthetic lethality. [PDF]

NPJ Syst Biol Appl
Vermeulen M, Craig AW, Babak T.
europepmc   +1 more source

Systematic Characterization of Cancer-Associated SPOP Mutants Reveals Novel and Reprogrammable Degradative Activities. [PDF]

Chembiochem
Caldwell AG, Parmar H, Jin X, Zhou C, Zhang X.   +4 more
europepmc   +1 more source

Bromodomain and Extraterminal Protein Inhibition: A Novel Therapeutic Strategy in Arthritis. [PDF]

J Inflamm Res
Sheng W, Zhao J, Yu F, Wang D, Zeng H, Liu P.   +5 more
europepmc   +1 more source

Peptide molecular glues select between BET paralogues by exploiting allosteric sites and conformational dynamics

Patel K, Mohanty B, Norman A, Franck C, Pachl P, Yang L, Jing X, Reid XJ, Walshe JL, Solomon P, Tran DH, Ford D, Low JKK, Wilkinson-White L, Passioura T, Payne RJ, Suga H, Walport LJ, Mackay JP.   +18 more
europepmc   +1 more source

The HYAL1 paradox in cancer: From complex tumor biology to novel therapeutic strategies. [PDF]

Transl Oncol
Jin Y, Wang T, Ma J, Quan J, Zhou N.
europepmc   +1 more source

Advantages of PROTACs in achieving selective degradation of homologous protein families. [PDF]

Beilstein J Org Chem
Yang L, Mao X, Zhang J, Shu J, Huang W, Dong X, Chen Y, Wu M.   +7 more
europepmc   +1 more source

A novel carboxamide bromodomain inhibitor attenuates osteoarthritis via epigenetic repression of NF-κB and MAPK signaling. [PDF]

Front Immunol
Lee H, Han SJ, Ok S, Lee KM, Choi S, Yoon I, Choi S, Kim J, Ryu S, Son MH, Lee IH, Cho C, Yang S.   +12 more
europepmc   +1 more source

Bromodomain and Extra-Terminal Family Proteins BRD2, BRD3, and BRD4 Contribute to H19-Dependent Transcriptional Regulation of Cell Adhesion Molecules, Modulating Metastatic Dissemination Program in Prostate Cancer. [PDF]

Noncoding RNA
Pecci V, Borsa M, Aiello A, De Martino S, Cis L, Ripoli C, Rotili D, Pierconti F, Pinto F, Grassi C, Gaetano C, Farsetti A, Nanni S.   +12 more
europepmc   +1 more source

Evaluation of Benzo[cd]indol-2(1H)-ones as Downstream Hedgehog Pathway Inhibitors. [PDF]

ChemistryOpen
Tsakoumagkos IA, Pasquer QTL, Guillod CL, Rossion C, Bagka M, Torche S, Sakata-Kato T, Chen JK, Hoogendoorn S.   +8 more
europepmc   +1 more source