Results 171 to 180 of about 5,434 (195)

BRD2 and TAP-1 genes and juvenile myoclonic epilepsy

Neurological Sciences, 2009
Juvenile myoclonic epilepsy (JME) is a genetically determined common subtype of idiopathic generalized epilepsy. Linkage of JME to the chromosomal region 6p21.3 has been reported. An association has been previously observed between JME and the positional candidate, 6p21.3 linked, BRD2.
Alain Malafosse, Thomas Pierre
exaly   +6 more sources

Distinct Roles of Brd2 and Brd4 in Potentiating the Transcriptional Program for Th17 Cell Differentiation [PDF]

Molecular Cell, 2017
The BET proteins are major transcriptional regulators and have emerged as new drug targets, but their functional distinction has remained elusive. In this study, we report that the BET family members Brd2 and Brd4 exert distinct genomic functions at genes whose transcription they co-regulate during mouse T helper 17 (Th17) cell differentiation. Brd2 is
Anbalagan Jaganathan, Rajal Sharma, Tong Shen   +2 more
exaly   +4 more sources

The chromatin-targeting protein Brd2 is required for neural tube closure and embryogenesis [PDF]

Biochimica Et Biophysica Acta - Gene Regulatory Mechanisms, 2009
Chromatin modifications are essential for directing transcription during embryonic development. Bromodomain-containing protein 2 (Brd2; also called RING3 and Fsrg1) is one of four BET (bromodomain and extra-terminal domain) family members known to selectively bind acetylated histones H3 and H4.
Kimberly A Seymour, Richard N Freiman
exaly   +3 more sources

The BET Protein BRD2 Cooperates with CTCF to Enforce Transcriptional and Architectural Boundaries [PDF]

Molecular Cell, 2017
Bromodomain and extraterminal motif (BET) proteins are pharmacologic targets for the treatment of diverse diseases, yet the roles of individual BET family members remain unclear. We find that BRD2, but not BRD4, co-localizes with the architectural/insulator protein CCCTC-binding factor (CTCF) genome-wide.
Sarah C Hsu, Thomas G Gilgenast, Caroline R Bartman   +2 more
exaly   +3 more sources

Structural Basis for Acetylated Histone H4 Recognition by the Human BRD2 Bromodomain [PDF]

Journal of Biological Chemistry, 2010
Recognition of acetylated chromatin by the bromodomains and extra-terminal domain (BET) family proteins is a hallmark for transcriptional activation and anchoring viral genomes to mitotic chromosomes of the host. One of the BET family proteins BRD2 interacts with acetylated chromatin during mitosis and leads to transcriptional activation in culture ...
Takashi Umehara, Moon Kyoo Jang, Balasundaram Padmanabhan   +2 more
exaly   +3 more sources

The bromodomain-containing gene BRD2 is regulated at transcription, splicing, and translation levels [PDF]

Journal of Cellular Biochemistry, 2011
The human BRD2 gene has been linked and associated with a form of common epilepsy and electroencephalographic abnormalities. Disruption of Brd2 in the mouse revealed that it is essential for embryonic neural development and that viable Brd2(+/-) heterozygotes show both decreased GABAergic neuron counts and increased susceptibility to seizures.
Enyuan Shang, Xiangyuan Wang, Cheryl L Beseler   +2 more
exaly   +3 more sources

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Natural variation of the BRD2 allele affects plant height and grain size in rice

Planta, 2022
The zqdm1 identified from a rice mutant is a novel allele of BRD2 and is responsible for regulating rice plant height, grain size and appearance, which has possibilities on improving rice quality. Plant height is an important agronomic trait related to rice yield, and grain size directly determines grain yield in rice (Oryza sativa L.).
Jinpeng Huang, Zhiming Chen, Jiajia Lin, Jinwen Chen, Menghao Wei, Liang Liu, Feng Yu, Zesen Zhang, Fangyu Chen, Liangrong Jiang, Jingsheng Zheng, Tiansheng Wang, Huiqing Chen, Wangyou Xie, Senhao Huang, Houcong Wang, Yumin Huang, Rongyu Huang   +17 more
openaire   +2 more sources

A Multicenter Study of BRD2 as a Risk Factor for Juvenile Myoclonic Epilepsy

Epilepsia, 2007
Summary:  Purpose: Although complex idiopathic generalized epilepsies (IGEs) are recognized to have a significant genetic component, as yet there are no known common susceptibility variants. It has recently been suggested that variation in the BRD2 gene confers increased risk of juvenile myoclonic epilepsy (JME), which accounts for around a quarter of
Cavalleri, Gianpiero L, Walley, Nicole, Soranzo, Nicole, Mulley, John C, Doherty, Colin P, Kapoor, Ashish, Depondt, Chantal, Lynch, John M, Scheffer, Ingrid E, Heils, Armin, Gehrmann, Anne, Kinirons, Peter, Gandhi, Sonia, Satishchandra, Parthasarathy, Wood, Nicholas W, Anand, Anuranjan, Sander, Thomas, Berkovic, S F, Delanty, Norman, Goldstein, David B, Sisodiya, Sanjay M   +20 more
openaire   +4 more sources

Assessing the impact of Brd2 depletion on chromatin compartmentalization

Abstract Recent insights into genome organization have emphasized the importance of A/B chromatin compartments. While our previous research showed that Brd2 depletion weakens compartment boundaries and promotes A/B mixing 1 , Hinojosa-Gonzalez et al. 2
Advait Athreya, Liangqi Xie, Robert Tjian, Bin Zhang, Zhe J. Liu   +4 more
openaire   +1 more source

Fucoxanthin prevents septic cardiomyopathy by targeting BRD2 in M1-polarized macrophages

Food & Function
Fucoxanthin targets BRD2 to inhibit macrophage M1-polarization, alleviating cardiomyocyte injury in septic cardiomyopathy.
Xuechun Sun, Tingwei Chen, Xiqing Zhang, Huali Meng, Yanqi Hu, Fang Zheng, Yufeng Chu, Lei Sun, Hao Wu   +8 more
openaire   +2 more sources