Results 21 to 30 of about 775 (136)

Immunopharmacology and Quantitative Analysis of Tyrosine Kinase Signaling. [PDF]

Curr Protoc Immunol, 2020
Abstract In this article we describe the use of pharmacological and genetic tools coupled with immunoblotting (Western blotting) and targeted mass spectrometry to quantify immune signaling and cell activation mediated by tyrosine kinases. Transfer of the ATP γ phosphate to a protein tyrosine residue activates signaling cascades regulating the ...
Brian BF, Guerrero CR, Freedman TS.
europepmc   +2 more sources

The Fyn-STAT5 Pathway: A New Frontier in IgE- and IgG-Mediated Mast Cell Signaling. [PDF]

Front Immunol, 2012
Mast cells are central players in immune surveillance and activation, positioned at the host–environment interface. Understanding the signaling events controlling mast cell function, especially those that maintain host homeostasis, is an important and ...
Pullen NA, Falanga YT, Morales JK, Ryan JJ.   +3 more
europepmc   +4 more sources

Universal Algorithm for Simulating and Evaluating Cyclic Voltammetry at Macroporous Electrodes by Considering Random Arrays of Microelectrodes

ChemPhysChem, Volume 21, Issue 5, Page 428-441, March 4, 2020., 2020
Simulating CV: The theory of cyclic voltammetry (CV) at macroporous electrodes is developed by considering random 1D, 2D and 3D arrays of microelectrodes. A universal algorithm for simulating the CV responses of the individual planar, cylindrical and spherical microelectrodes, is presented as well. Experimental data support the proposed model. Finally,
Tim Tichter, Jonathan Schneider, Dirk Andrae, Marcus Gebhard, Christina Roth   +4 more
wiley   +1 more source

Electrochemical Analysis of Metallothionein in Chicken Exposed to Cadmium Ions

International Journal of Electrochemical Science, 2015
Metallothionein as a protective protein has been studied in relationship to cancer diseases, toxicity of anticancer drugs and environmental pollution. Its electrochemical detection is based on Brdicka´s reaction suitable for the protein detection.
Katerina Tmejova, David Hynek, Renata Kensova, Iva Blazkova, Lenka Vyslouzilova, Olga Stepankova, Miroslav Pohanka, Josef Zehnalek, Marketa Vaculovicova, Vojtech Adam, Rene Kizek   +10 more
doaj   +1 more source

A comparative study of the electrochemical properties of vitamin B-6 related compounds at physiological pH [PDF]

, 2011
A comparative study of vitamin B6 group and related compounds in buffered solutions using electrochemical techniques has been performed at neutral pH.
A. Pocker, A. Temizer, A.E. Braunstein, A.J. Bard, A.J. Román, A.K. Lunn, C.M. Harris, C.M. Metzler, D. Manousek, E.E. Snell, H. Lund, J. Gonzalez-Rodríguez, J. Llor, J. Llor, J. M. Sevilla, J.M. Rodríguez Mellado, J.M. RodrÍguez Mellado, J.M. RodrÍguez Mellado, J.M. RodrÍguez Mellado, L. Camacho, M. Blázquez, M. Blázquez, M. Heyrovský, M. Stanulovic, M.L. Ahrens, M.S. Ibrahim, N.P. Bazhulina, P. Zuman, P. Zuman, R. Izquierdo, R. Izquierdo, R. Schwartz, S.G. Mairanoskii, T. Pineda, T. Pineda, T. Pineda, V. Mirceski, W.F. Wolkers, Y.V. Morozov   +38 more
core   +1 more source

Electrochemical Behaviour of Native and Denatured β-Sheet Breaker Prion Protein

International Journal of Electrochemical Science, 2012
Prion diseases are fatal neurodegenerative and infectious disorders of humans and animals, characterized by structural transition of the host-encoded cellular prion protein (PrPC) into the aberrantly folded pathologic isoform PrPSc.
Pavlina Sobrova, Marketa Ryvolova, David Hynek, Vojtech Adam, Jaromir Hubalek, Rene Kizek   +5 more
doaj   +1 more source

Beads Based Electrochemical Assay for Detection of Hemagglutinin Labeled by Two Different Types of Cadmium Quantum Dots

International Journal of Electrochemical Science, 2014
In this study it is described beads based isolation assay terminated by electrochemical analysis of hemagglutinin (HA) using two different cadmium quantum dots (QDs) labelled as CdS and CdTe.
Ludmila Krejcova, David Hynek, Roman Guran, Petr Michalek, Amitava Moulick, Pavel Kopel, Katerina Tmejova, Nguien Viet Hoai, Vojtech Adam, Jaromir Hubalek, Jindrich Kynicky, Rene Kizek   +11 more
doaj   +1 more source

The REST Gene Signature Predicts Drug Sensitivity in Neuroblastoma Cell Lines and Is Significantly Associated with Neuroblastoma Tumor Stage [PDF]

, 2014
Neuroblastoma is the most common and deadly solid tumor in children, and there is currently no effective treatment available for neuroblastoma patients. The repressor element-1 silencing transcription (REST) factor has been found to play important roles ...
Li, Yaqiao, Liang, Jianfeng, Tong, Pan, Xia, Ying, Yu, Yanbing, Zhang, Li, Zhao, Wanni   +6 more
core   +2 more sources

The Electrochemical and Statistical Evaluation of Isolation of Mellitin and Apamin from Honey Bee (Apis Mellifera) Venom

International Journal of Electrochemical Science, 2015
We present in this manuscript for the first time the electrochemical and statistical evaluation of FPLC isolation of mellitin and apamin from honey bee (Apis mellifera) venom. Venoms are extremely complex blends of diverse substances that target a myriad
Hoai Viet Nguyen, Zbynek Heger, Marketa Kominkova, Petr Michalek, Jaromir Gumulec, Roman Guran, Antonin Pridal, Carlos Fernandez, David Hynek, Vojtech Adam, Rene Kizek   +10 more
doaj   +1 more source

Impact of cadmium on the level of hepatic metallothioneins, essential elements, and selected enzymes in the experimental rat model

Czech Journal of Animal Science, 2014
The response of different strains of laboratory rats (Rattus norvegicus L.) on both acute (via intraperitoneal injection) and chronic (via drinking water and/or diet) cadmium intoxication was investigated in the model study.
J. Zídková, M. Melčová, K. Bartošová, I. Šestáková, V. Zídek, J. Száková, D. Miholová, P. Tlustoš   +7 more
doaj   +1 more source