Results 31 to 40 of about 722,190 (298)

Novel TCAD oriented definition of the off-state breakdown voltage in Schottky-gate FETs: a 4H SiC MESFET case study [PDF]

, 2008
Physics-based breakdown voltage optimization in Schottky-barrier power RF and microwave field-effect transistors as well as in high-speed power-switching diodes is today an important topic in technology computer-aided design (TCAD).
Bonani, Fabrizio, Furno, M., Ghione, Giovanni, FURNO M   +3 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Effect of Frequency on Degradation in BOPP Films Under Repetitively Pulsed Voltage

CSEE Journal of Power and Energy Systems
Operating conditions of film capacitors are complex, and the problem of film insulation failure caused by repetitively pulsed voltage is becoming ever serious.
Chuansheng Zhang, Yu Feng, Fei Kong, Bangdou Huang, Cheng Zhang, Tao Shao   +5 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Characteristics Comparison of SiC and GaN Extrinsic Vertical Photoconductive Switches

IEEE Journal of the Electron Devices Society
Vertical extrinsic photoconductive semiconductor switches (PCSSs) are presented with initial characteristics comparison between V-doped 4H-SiC and Fe-doped GaN PCSS under axial triggering such as dark resistance, photoconductivity, power output, and ...
Linglong Zeng, Langning Wang, Xinyue Niu, Fuyin Liu, Ting He, Yanran Gu, Muyu Yi, Jinmei Yao, Tao Xun, Hanwu Yang   +9 more
doaj   +1 more source

Restarting from Specific Points to Cure Breakdown in Lanczos-type Algorithms

Journal of Mathematical and Fundamental Sciences, 2015
Breakdown in Lanczos-type algorithms is a common phenomenon which is due to the non-existence of some orthogonal polynomials. It causes the solution process to halt.
Maharani, Abdellah Salhi
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Laser-induced breakdown of an optically trapped gold nanoparticle for single cell transfection [PDF]

, 2013
The cell selective introduction of therapeutic agents remains a challenging problem. Here we demonstrate spatially controlled cavitation instigated by laser-induced breakdown of an optically trapped single gold nanoparticle of diameter 100 nm. The energy
Gunn-Moore, Frank J, Arita, Yoshihiko, Antkowiak, Maciej, Ploschner, Martin, Dholakia, Kishan, Yoshihiko Arita, Maciej Antkowiak, Frank Gunn-Moore, Gunn-Moore, Frank, Martin Ploschner, Kishan Dholakia   +10 more
core   +1 more source