Results 41 to 50 of about 477,993 (266)

Using Modeling and Simulation to Study the Influence of TiO2 Shape on the Dielectric Properties of TiO2/PVDF Composite

Journal of Harbin University of Science and Technology, 2022
TiO2/PVDF composite materials have excellent high dielectric properties and have wide application prospects in the fields of high voltage and energy storage insulation.In this paper, the finite element method was used to simulate the structure and ...
SHAN Xue-wen, YIN Jing-hua
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Efeito das condições de atmosfera controlada sobre a ocorrência de degenerescência em maçã 'Fuji' Effect of controlled atmosphere conditions on the breakdown of 'Fuji' apples

Scientia Agricola, 1995
O trabalho foi conduzido durante o ano de 1993, com objetivo avaliar o efeito das temperaturas e concentrações de oxigênio nas câmaras de atmosfera controlada (AC), sobre a manifestação da degenerescência e conservação da qualidade dos frutos da maçã ...
A. Brackmann, A.A. Saquet
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Experimental research of ECW pre-ionization and assisted startup in EAST

Nuclear Fusion
Experimental research on the electron cyclotron wave (ECW) pre-ionization and assisted start-up was carried out systematically for the first time in EAST tokamak, which is a superconducting device with ITER-like full metal wall.
Runze Chen, Wenbin Liu, Jinping Qian, Bin Zhang, Hongjuan Sun, Zhengping Luo, Yaowei Yu, Wei Gao, Miaohui Li, Handong Xu, Mao Wang, Guizhong Zuo, Ling Zhang, Ruijie Zhou, Tianqi Jia, Pan Li, Wei Wang, Yifan He, Zuhao Wang, Ye Tao, Yunchan Hu, Zhongfang Guan, Wenyi Lu, Yutong Guo, Xianzu Gong   +24 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

THE EVOLUTION AND BREAKDOWN OF TRISTYLY [PDF]

Evolution, 1979
In a tristylic species three types of individuals, distinguished by their flower morphology, occur. One form has a long style, while the anthers are in two whorls, one very low down, and one about half way between the stigma and the low anther whorl. The three positions of the sex organs in this form (called long or L) define three positions that can ...
openaire   +2 more sources

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Impact of Electrode Distance in a Quasi-Uniform Model Electrode System on Lightning Impulse Breakdown Voltage in Various Insulating Liquids

Energies
This study presents findings on the influence of gap length distance on the lightning impulse breakdown voltage of three dielectric liquids of different chemical origins.
Wiktor Kunikowski, Pawel Rozga, Bartlomiej Pasternak, Jakub Staniewski, Filip Stuchala, Konrad Strzelecki   +5 more
doaj   +1 more source