Results 41 to 50 of about 236,252 (266)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Breakdown as Method: Screenshots for Dying Worlds

open access: yesMedia Theory, 2022
Drawing on John Durham Peters’ theory of (mis)communication and other studies of precarious infrastructure (Hicks, 2020; Star, 1999; Pow, 2021; Tsing, 2015), in this article, I consider mortality or finitude as a site of communication breakdown ...
Tamara Kneese
doaj   +1 more source

The Masking Breakdown Point of Multivariate Outlier Identification Rules [PDF]

open access: yesJournal of the American Statistical Association, 1999
In this paper, we consider one-step outlier identifiation rules for multivariate data, generalizing the concept of so-called alpha outlier identifiers, as presented in Davies and Gather (1993) for the case of univariate samples. We investigate, how the finite-sample breakdown points of estimators used in these identification rules influence the masking
Becker, Claudia, Gather, Ursula
openaire   +4 more sources

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola   +12 more
wiley   +1 more source

Indirectly Measured Ambient Electric Fields for Lightning Initiation in Fast Breakdown Regions

open access: yesGeophysical Research Letters, 2020
We report a new approach to measure indirectly the ambient thunderstorm electric fields in fast positive breakdown regions. For a given geometry of the discharged fast breakdown region, we show that there is a minimum ambient electric field required to ...
Steven A. Cummer
doaj   +1 more source

Breakdown of conformal invariance at strongly random critical points [PDF]

open access: yesPhysical Review B, 2001
We consider the breakdown of conformal and scale invariance in random systems with strongly random critical points. Extending previous results on one-dimensional systems, we provide an example of a three-dimensional system which has a strongly random critical point.
Hastings, M. B., Sondhi, S. L.
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Effect of the Competitive Adsorption of Borate and Chloride Ions on the Breakdown Potential of Iron

open access: yesInternational Journal of Electrochemical Science, 2018
The effect of acl−aB(OH)4−on the passivity breakdown for pure iron in borate buffer solution containing chloride ions has been studied and the results also have been analyzed using the Point Defect Model (PDM).
Yuting Zhou   +5 more
doaj   +1 more source

Using AHP to improve manufacturing processes in TPM on industrial and port complex

open access: yesExacta, 2021
This paper aimed to develop a model to rank the critical factors for the improvement of the production process from the point of view of Total Productive Maintenance (TPM) in six companies located in the Suape Industrial Complex region.
Fagner José Coutinho de Melo   +3 more
doaj   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

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