Results 51 to 60 of about 1,240,548 (287)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Inference on Breakdown Frontiers
, 2019 Given a set of baseline assumptions, a breakdown frontier is the boundary between the set of assumptions which lead to a specific conclusion and those which do not. In a potential outcomes model with a binary treatment, we consider two conclusions: First,
Masten, Matthew A., Poirier, Alexandre
core +1 more source
Energies, 2022 The impulse breakdown attributes are of rudimentary importance in the insulation coordination in the gas-insulated switchgear (GIS). The critical voltage waveshape for the insulation is the surge over voltages.
Rashed Meer +3 more
doaj +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Breakdown as Method: Screenshots for Dying Worlds
Media Theory, 2022 Drawing on John Durham Peters’ theory of (mis)communication and other studies of precarious infrastructure (Hicks, 2020; Star, 1999; Pow, 2021; Tsing, 2015), in this article, I consider mortality or finitude as a site of communication breakdown ...
Tamara Kneese
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Quantum Boltzman equation study for the Kondo breakdown quantum critical point
, 2009 We develop the quantum Boltzman equation approach for the Kondo breakdown quantum critical point, involved with two bands for conduction electrons and localized fermions. Particularly, the role of vertex corrections in transport is addressed, crucial for
Kim, KS, null, Pepin, C
core +1 more source
How nonlinear interactions challenge the three-dimensional Anderson transition [PDF]
, 2014 In disordered systems, our present understanding of the Anderson transition is hampered by the possible presence of interactions between particles. We demonstrate that in boson gases, even weak interactions deeply alter the very nature of the Anderson ...
Cherroret, Nicolas +3 more
core +3 more sources
Indirectly Measured Ambient Electric Fields for Lightning Initiation in Fast Breakdown Regions
Geophysical Research Letters, 2020 We report a new approach to measure indirectly the ambient thunderstorm electric fields in fast positive breakdown regions. For a given geometry of the discharged fast breakdown region, we show that there is a minimum ambient electric field required to ...
Steven A. Cummer
doaj +1 more source