Results 51 to 60 of about 4,689,601 (244)

The Estimation of Lightning Impulses Superimposed onto Pre-Stressed DC Breakdown Voltages Using the Leader Propagation Method

open access: yesEnergies, 2022
The impulse breakdown attributes are of rudimentary importance in the insulation coordination in the gas-insulated switchgear (GIS). The critical voltage waveshape for the insulation is the surge over voltages.
Rashed Meer   +3 more
doaj   +1 more source

Thermopower as a fingerprint of the Kondo breakdown quantum critical point [PDF]

open access: yesPhysical Review B, 2011
We propose that the thermoelectric power distinguishes two competing scenarios for quantum phase transitions in heavy fermions : the spin-density-wave (SDW) theory and breakdown of the Kondo effect. In the Kondo breakdown scenario, the Seebeck coefficient turns out to collapse from the temperature scale $E^{*}$, associated with quantum fluctuations of ...
Kim, K. -S., Pepin, C.
openaire   +2 more sources

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Indirectly Measured Ambient Electric Fields for Lightning Initiation in Fast Breakdown Regions

open access: yesGeophysical Research Letters, 2020
We report a new approach to measure indirectly the ambient thunderstorm electric fields in fast positive breakdown regions. For a given geometry of the discharged fast breakdown region, we show that there is a minimum ambient electric field required to ...
Steven A. Cummer
doaj   +1 more source

Breakdown as Method: Screenshots for Dying Worlds

open access: yesMedia Theory, 2022
Drawing on John Durham Peters’ theory of (mis)communication and other studies of precarious infrastructure (Hicks, 2020; Star, 1999; Pow, 2021; Tsing, 2015), in this article, I consider mortality or finitude as a site of communication breakdown ...
Tamara Kneese
doaj   +1 more source

The Threshold Breakdown Point

open access: yes
We introduce a novel approach to finite sample robustness that avoids the pessimism of traditional breakdown analyses. We define the threshold breakdown point, the smallest contamination fraction needed to induce a prescribed deviation, and the finite sample m-sensitivity, the worst-case deviation that an estimator can incur after m observations are ...
Ke, Tianjun, Medina, Marco Avella
openaire   +2 more sources

Breakdown of conformal invariance at strongly random critical points [PDF]

open access: yesPhysical Review B, 2001
We consider the breakdown of conformal and scale invariance in random systems with strongly random critical points. Extending previous results on one-dimensional systems, we provide an example of a three-dimensional system which has a strongly random critical point.
Hastings, M. B., Sondhi, S. L.
openaire   +2 more sources

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

open access: yesFEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante   +10 more
wiley   +1 more source

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