Results 51 to 60 of about 255,891 (299)

Low-Area Four-Channel Controlled Dielectric Breakdown System Design for Point-of-Care Applications

Sensors, 2022
In this study, we propose a low-area multi-channel controlled dielectric breakdown (CDB) system that simultaneously produces several nanopore sensors. Conventionally, solid-state nanopores are prepared by etching or drilling openings in a silicon nitride
Jonggi Hong, Yeonji Oh, Hojong Choi, Jungsuk Kim   +3 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The Estimation of Lightning Impulses Superimposed onto Pre-Stressed DC Breakdown Voltages Using the Leader Propagation Method

Energies, 2022
The impulse breakdown attributes are of rudimentary importance in the insulation coordination in the gas-insulated switchgear (GIS). The critical voltage waveshape for the insulation is the surge over voltages.
Rashed Meer, Yasin Khan, Nissar Rasool Wani, Abdulrahman Ali Al-Arainy   +3 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Breakdown as Method: Screenshots for Dying Worlds

Media Theory, 2022
Drawing on John Durham Peters’ theory of (mis)communication and other studies of precarious infrastructure (Hicks, 2020; Star, 1999; Pow, 2021; Tsing, 2015), in this article, I consider mortality or finitude as a site of communication breakdown ...
Tamara Kneese
doaj   +1 more source

Breakdown of conformal invariance at strongly random critical points [PDF]

Physical Review B, 2001
We consider the breakdown of conformal and scale invariance in random systems with strongly random critical points. Extending previous results on one-dimensional systems, we provide an example of a three-dimensional system which has a strongly random critical point.
Hastings, M. B., Sondhi, S. L.
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Indirectly Measured Ambient Electric Fields for Lightning Initiation in Fast Breakdown Regions

Geophysical Research Letters, 2020
We report a new approach to measure indirectly the ambient thunderstorm electric fields in fast positive breakdown regions. For a given geometry of the discharged fast breakdown region, we show that there is a minimum ambient electric field required to ...
Steven A. Cummer
doaj   +1 more source

The Threshold Breakdown Point

We introduce a novel approach to finite sample robustness that avoids the pessimism of traditional breakdown analyses. We define the threshold breakdown point, the smallest contamination fraction needed to induce a prescribed deviation, and the finite sample m-sensitivity, the worst-case deviation that an estimator can incur after m observations are ...
Ke, Tianjun, Medina, Marco Avella
openaire   +2 more sources