Results 61 to 70 of about 918,929 (287)

The Suppression and Recovery of the Ferroelectric Phase in Multiferroic $MnWO_4$

open access: yes, 2008
We report the discovery of a complete suppression of ferroelectricity in $MnWO_4$ by 10 % iron substitution and its restoration in external magnetic fields. The spontaneous polarization in $Mn_{0.9}Fe_{0.1}WO_4$ arises below 12 K in external fields above
B. Lorenz   +6 more
core   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

Heat Capacity Effects Associated with the Hydrophobic Hydration and Interaction of Simple Solutes: A Detailed Structural and Energetical Analysis Based on MD Simulations

open access: yes, 2004
We examine the SPCE and TIP5P water models to study heat capacity effects associated with the hydrophobic hydration and interaction of Xenon particles. We calculate the excess chemical potential for Xenon employing the Widom particle insertion technique.
Dietmar Paschek, Lee B., Lindahl E.
core   +1 more source

Numerical simulation of the shape of charged drops over a solid surface. [PDF]

open access: yes, 2010
In this work we study the static shape of charged drops of a conducting fluid placed over a solid substrate, surrounded by a gas, and in absence of gravitational forces.
Fontelos, Marco Antonio   +1 more
core   +2 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Multi-phonon scattering and Ti-induced hydrogen dynamics in sodium alanate

open access: yes, 2004
We use ab initio methods and neutron inelastic scattering (NIS) to study the structure, energetics, and dynamics of pure and Ti-doped sodium alanate (NaAlH_4), focusing on the possibility of substitutional Ti doping.
B. Bogdanovic   +11 more
core   +1 more source

Dual gauge field theory of quantum liquid crystals in two dimensions [PDF]

open access: yes, 2017
We present a self-contained review of the theory of dislocation-mediated quantum melting at zero temperature in two spatial dimensions. The theory describes the liquid-crystalline phases with spatial symmetries in between a quantum crystalline solid and ...
Beekman, Aron J.   +7 more
core   +3 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Correlations between hidden units in multilayer neural networks and replica symmetry breaking

open access: yes, 1999
We consider feed-forward neural networks with one hidden layer, tree architecture and a fixed hidden-to-output Boolean function. Focusing on the saturation limit of the storage problem the influence of replica symmetry breaking on the distribution of ...
A. Engel   +20 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

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