Results 81 to 90 of about 918,929 (287)
Insights into a long life without cancer: The case of the bowhead whale
Molecular Oncology, EarlyView.Long‐lived, large‐bodied organisms have evolved powerful anticancer mechanisms that preserve cellular and tissue integrity across extended lifespans. A recent study by Firsanov et al. shows that greater genome stability is a key factor underlying the remarkable longevity and cancer resistance of one such species, the bowhead whale.
Inés Paniagua, Johanna A. Joyce
wiley +1 more source
Jixie chuandong, 2013 The strength calculation of the parts breaking in the reducerof steel ball coal mill is carried out.The main breaking factors are analyzed by combiningwith the real working characteristic of steel ball coal mill.Based on the analysis and calculation ...
张晨晨, 杨国华
doaj
, 2012 We study a versatile structurally favorable periodic $sp^2$-bonded carbon atomic planar sheet with $C_{4v}$ symmetry by means of the first-principles calculations. This carbon allotrope is composed of carbon octagons and squares with two bond lengths and
Cui, Hui-Juan +5 more
core +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
AIP AdvancesThe moving contact speed of DC miniature circuit breakers (MCBs) directly affects the arcing characteristics in the arc chamber, thus affecting their breaking capacity. Based on this, this paper studies the arcing characteristics in the arc chamber under
Jie Zhang +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Parameter Optimization and Experimental Study of Particle Jet Impact Rock Breaking Nozzle
Shiyou jixie, 2018 As a core accelerating device of particles and water jet during particle jet impact rock breaking process, the nozzle’s accelerating ability determines the effect of rock breaking. On account of the straight-taper nozzle, the constant-acceleration nozzle
Ren Fushen, Fang Tiancheng, Cheng Xiaoze
doaj
IEEE Access, 2020 The high performance of medium-voltage direct current (MVDC) power supply system is a pre-requisite for several industrial applications. To meet the higher voltage direct current (DC) breaking requirements in the fields of aviation, aerospace, and new ...
Bowen Jia +5 more
doaj +1 more source
, 2016 Object detection systems based on the deep convolutional neural network (CNN) have recently made ground- breaking advances on several object detection benchmarks.
Lee, Honglak +4 more
core +1 more source