Results 31 to 40 of about 393,599 (169)

The tumor suppressor DACT3 sensitizes triple-negative breast cancer to apatinib by inhibiting the Wnt/β-catenin pathway

Translational Oncology
Apatinib, a small-molecule inhibitor of vascular endothelial growth factor receptor 2 (VEGFR2), shows efficient antitumor activity in heavily pretreated metastatic triple-negative breast cancer (TNBC).
Jing Wu, Rui Tian, Mei Liu, Yijing Liu, Bianfei Shao, Xiaohua Zeng   +5 more
doaj   +1 more source

Denosumab treatment is associated with the absence of circulating tumor cells in patients with breast cancer

Breast Cancer Research, 2018
Background The presence of circulating tumor cells (CTCs) in patients with breast cancer correlates to a bad prognosis. Yet, CTCs are detectable in only a minority of patients with progressive breast cancer, and factors that influence the abundance of ...
Marcus Vetter, Julia Landin, Barbara Maria Szczerba, Francesc Castro-Giner, Sofia Gkountela, Cinzia Donato, Ilona Krol, Ramona Scherrer, Catharina Balmelli, Alexandra Malinovska, Alfred Zippelius, Christian Kurzeder, Viola Heinzelmann-Schwarz, Walter Paul Weber, Christoph Rochlitz, Nicola Aceto   +15 more
doaj   +1 more source

Massive metastasis of breast cancer to female genital organs

Taiwanese Journal of Obstetrics & Gynecology, 2021
Objective: Breast cancer metastasis to the female genital tract is rare, and the ovaries are the most frequent site of extragenital cancer metastasis. The uterus and cervix have been rarely reported as the site of metastasis.
Ling Lim, Tao-Yeuan Wang, Hung-Bun Lam, Chih-Long Chang   +3 more
doaj   +1 more source

Metastasis of Colon Cancer to the Breast [PDF]

Case Reports in Oncology, 2017
Breast metastases from extramammary neoplasms are extremely rare, and even more so is metastasis of colon cancer to the breast. Despite its rarity, metastatic disease to the breast is an important diagnostic issue because its treatment differs greatly from that of primary cancer. Proper diagnosis of this rare event requires an accurate clinical history,
openaire   +3 more sources

Single-Cell Transcriptomics Reveals the Potential Role of GZMK+ CD8+ T Cells in Cell Senescence of Triple-Negative Breast Cancer

International Journal of Genomics
Senescence is a critical risk factor for the development of triple-negative breast cancer (TNBC), yet its specific impact on the disease remains inadequately understood.
Dan Zhou, Tianhui Hu, Beibei Xu, Jiachen Zhu, Miaomiao Ma, Wenqing Zhang, Liangxi Xie, Zhong Ouyang, Yidan Xu, Yongcheng Su   +9 more
doaj   +1 more source

C1QL1 inhibits breast cancer through the HSP90α/VCP-ERS/UPR axis

Experimental and Molecular Medicine
Our earlier research discovered that C1QL1 was expressed less in breast cancer (BrCa) tissues than in normal breast tissues by analyzing the gene profile of RNA sequences.
Ningning Zhang, Qing Shao, Xinni Xiang, Chun Yan, Dan Tao, Qian Li, Huan Rong, Yi Zhao, Tingxiu Xiang, Xiaohua Zeng   +9 more
doaj   +1 more source

Visualizing cellular interactions: intravital imaging in tumor microenvironment

Frontiers in Immunology
The tumor milieu is a dynamic ecosystem where immune cells, stromal cells, and tumor cells interact to influence tumor progression and anti-tumor immunity.
Shichao Li, Shichao Li, Limei Liu, Juanjuan Shan, Cheng Qian   +4 more
doaj   +1 more source

Breast metastases: A rare manifestation of advanced uterine serous carcinoma

Gynecologic Oncology Reports, 2019
Metastasis of non-mammary tumors to the breast are uncommon, representing
Jennifer McEachron, Rachel Mendoza, Yi-Chun Lee, Margaux J. Kanis   +3 more
doaj   +1 more source

Matrix mechano-sensing at the invasive front induces a cytoskeletal and transcriptional memory supporting metastasis

Nature Communications
The extracellular matrix (ECM) controls tumour dissemination. We characterise ECM organization in human and mouse tumours, identifying three regions: tumour body, proximal invasive front and distal invasive front.
Oscar Maiques, Marta C. Sallan, Roman Laddach, Pahini Pandya, Adrian Varela, Eva Crosas-Molist, Jaume Barcelo, Olivia Courbot, Yanbo Liu, Vittoria Graziani, Youssef Arafat, Joanne Sewell, Irene Rodriguez-Hernandez, Bruce Fanshawe, Yaiza Jung-Garcia, Paul RC Imbert, Eloise M. Grasset, Jean Albrengues, Maria Santacana, Anna Macià, Jordi Tarragona, Xavier Matias-Guiu, Rosa M. Marti, Sophia Tsoka, Cedric Gaggioli, Jose L. Orgaz, Gilbert O. Fruhwirth, Fredrik Wallberg, Kai Betteridge, Constantino Carlos Reyes-Aldasoro, Syed Haider, Andrejs Braun, Sophia N. Karagiannis, Alberto Elosegui-Artola, Victoria Sanz-Moreno   +34 more
doaj   +1 more source

New insight into long non-coding RNAs associated with bone metastasis of breast cancer based on an integrated analysis

Cancer Cell International, 2021
Background Bone is the most common site of metastatic breast cancer, and it is a leading cause of breast cancer-related death. This study aimed to explore bone metastasis-related long non-coding RNAs (lncRNAs) in breast cancer. Methods Four mRNA datasets
Yu Zhang, Xiaofeng Huang, Jin Liu, Guo Chen, Chengjun Liu, Sen Zhang, Jiaxin Li   +6 more
doaj   +1 more source