Results 31 to 40 of about 386,647 (265)

EGFR-Mutated Breast Metastasis of Lung Adenocarcinoma: A Case Report

Case Reports in Oncology, 2015
Breast metastasis from other primary carcinoma is very rare and could be difficult to identify despite immunohistochemistry analysis. Breast metastasis from lung adenocarcinoma can mimic triple-negative breast cancer.
Eric Dansin, Aurélien Carnot, Véronique Servent, Dorothée Daussay, Yves-Marie Robin, Ecaterina Surmei-Pintilie, Géraldine Lauridant, Clothilde Descarpentries, Françoise Révillion, Claire Delattre   +9 more
doaj   +1 more source

Denosumab treatment is associated with the absence of circulating tumor cells in patients with breast cancer

Breast Cancer Research, 2018
Background The presence of circulating tumor cells (CTCs) in patients with breast cancer correlates to a bad prognosis. Yet, CTCs are detectable in only a minority of patients with progressive breast cancer, and factors that influence the abundance of ...
Marcus Vetter, Julia Landin, Barbara Maria Szczerba, Francesc Castro-Giner, Sofia Gkountela, Cinzia Donato, Ilona Krol, Ramona Scherrer, Catharina Balmelli, Alexandra Malinovska, Alfred Zippelius, Christian Kurzeder, Viola Heinzelmann-Schwarz, Walter Paul Weber, Christoph Rochlitz, Nicola Aceto   +15 more
doaj   +1 more source

Hubungan Kadar Cancer Antigen 15-3 Serum dengan Metastasis Kanker Payudara

Jurnal Ilmu Kesehatan Indonesia, 2021
Background: CA 15-3 serum is one of the tumor marker that has been recommended by American Soviety of Clinical Oncology to show the response of the therapy, prognosis and metastasis of the breast cancer.
Fakhriyyatur Rahmi M, Rikarni Rikarni, Nora Harminarti   +2 more
doaj   +1 more source

The tumor suppressor DACT3 sensitizes triple-negative breast cancer to apatinib by inhibiting the Wnt/β-catenin pathway

Translational Oncology
Apatinib, a small-molecule inhibitor of vascular endothelial growth factor receptor 2 (VEGFR2), shows efficient antitumor activity in heavily pretreated metastatic triple-negative breast cancer (TNBC).
Jing Wu, Rui Tian, Mei Liu, Yijing Liu, Bianfei Shao, Xiaohua Zeng   +5 more
doaj   +1 more source

Single-Cell Transcriptomics Reveals the Potential Role of GZMK+ CD8+ T Cells in Cell Senescence of Triple-Negative Breast Cancer

International Journal of Genomics
Senescence is a critical risk factor for the development of triple-negative breast cancer (TNBC), yet its specific impact on the disease remains inadequately understood.
Dan Zhou, Tianhui Hu, Beibei Xu, Jiachen Zhu, Miaomiao Ma, Wenqing Zhang, Liangxi Xie, Zhong Ouyang, Yidan Xu, Yongcheng Su   +9 more
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Orbital Metastasis of Breast Carcinoma

Breast Cancer: Basic and Clinical Research, 2009
We report a case of orbital metastasis in a previously diagnosed metastatic breast cancer in a 46-year old woman presenting with diplopia and proptosis of her left eye bulb. An orbital computed-tomography (CT) and a magnetic resonance imaging (MRI) both revealed an intra-orbital extra-bulbar mass of 1.5 × 3 cm in size, in the left orbit.
Panagiotis J, Vlachostergios, Ioannis A, Voutsadakis, Christos N, Papandreou   +2 more
openaire   +2 more sources

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

C1QL1 inhibits breast cancer through the HSP90α/VCP-ERS/UPR axis

Experimental and Molecular Medicine
Our earlier research discovered that C1QL1 was expressed less in breast cancer (BrCa) tissues than in normal breast tissues by analyzing the gene profile of RNA sequences.
Ningning Zhang, Qing Shao, Xinni Xiang, Chun Yan, Dan Tao, Qian Li, Huan Rong, Yi Zhao, Tingxiu Xiang, Xiaohua Zeng   +9 more
doaj   +1 more source