Results 31 to 40 of about 404,237 (268)

Metastasis of Colon Cancer to the Breast [PDF]

Case Reports in Oncology, 2017
Breast metastases from extramammary neoplasms are extremely rare, and even more so is metastasis of colon cancer to the breast. Despite its rarity, metastatic disease to the breast is an important diagnostic issue because its treatment differs greatly from that of primary cancer. Proper diagnosis of this rare event requires an accurate clinical history,
openaire   +3 more sources

The tumor suppressor DACT3 sensitizes triple-negative breast cancer to apatinib by inhibiting the Wnt/β-catenin pathway

Translational Oncology
Apatinib, a small-molecule inhibitor of vascular endothelial growth factor receptor 2 (VEGFR2), shows efficient antitumor activity in heavily pretreated metastatic triple-negative breast cancer (TNBC).
Jing Wu, Rui Tian, Mei Liu, Yijing Liu, Bianfei Shao, Xiaohua Zeng   +5 more
doaj   +1 more source

Denosumab treatment is associated with the absence of circulating tumor cells in patients with breast cancer

Breast Cancer Research, 2018
Background The presence of circulating tumor cells (CTCs) in patients with breast cancer correlates to a bad prognosis. Yet, CTCs are detectable in only a minority of patients with progressive breast cancer, and factors that influence the abundance of ...
Marcus Vetter, Julia Landin, Barbara Maria Szczerba, Francesc Castro-Giner, Sofia Gkountela, Cinzia Donato, Ilona Krol, Ramona Scherrer, Catharina Balmelli, Alexandra Malinovska, Alfred Zippelius, Christian Kurzeder, Viola Heinzelmann-Schwarz, Walter Paul Weber, Christoph Rochlitz, Nicola Aceto   +15 more
doaj   +1 more source

Single-Cell Transcriptomics Reveals the Potential Role of GZMK+ CD8+ T Cells in Cell Senescence of Triple-Negative Breast Cancer

International Journal of Genomics
Senescence is a critical risk factor for the development of triple-negative breast cancer (TNBC), yet its specific impact on the disease remains inadequately understood.
Dan Zhou, Tianhui Hu, Beibei Xu, Jiachen Zhu, Miaomiao Ma, Wenqing Zhang, Liangxi Xie, Zhong Ouyang, Yidan Xu, Yongcheng Su   +9 more
doaj   +1 more source

Breast cancer metastasis to the conjunctiva

Vojnosanitetski pregled, 2013
Introduction. Conjunctival metastasis is exceedingly rare, and it is, as a rule, a sign of advanced malignant disease with poor prognosis. We presented a female patient with breast cancer metastasis to the conjunctiva. Case report. A 45-yearold premenopausal female patient was presented with a solitary, yellowish, thin, demarcated lesion in
Anica Bobic-Radovanovic, Dejan Rasic, Marko Buta, Radan Dzodic   +3 more
openaire   +3 more sources

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

C1QL1 inhibits breast cancer through the HSP90α/VCP-ERS/UPR axis

Experimental and Molecular Medicine
Our earlier research discovered that C1QL1 was expressed less in breast cancer (BrCa) tissues than in normal breast tissues by analyzing the gene profile of RNA sequences.
Ningning Zhang, Qing Shao, Xinni Xiang, Chun Yan, Dan Tao, Qian Li, Huan Rong, Yi Zhao, Tingxiu Xiang, Xiaohua Zeng   +9 more
doaj   +1 more source

Visualizing cellular interactions: intravital imaging in tumor microenvironment

Frontiers in Immunology
The tumor milieu is a dynamic ecosystem where immune cells, stromal cells, and tumor cells interact to influence tumor progression and anti-tumor immunity.
Shichao Li, Shichao Li, Limei Liu, Juanjuan Shan, Cheng Qian   +4 more
doaj   +1 more source