Results 91 to 100 of about 858,528 (292)

Metformin Reshapes the Methylation Profile in Breast and Colorectal Cancer Cells

Asian Pacific journal of cancer prevention : APJCP, 2018
With no sharp cure, breast cancer still be the major and the most serious life-threatening disease worldwide. Colorectal is the third most commonly occurring cancer in men and the second most commonly occurring cancer in women. In the present investigation, colon cancer cells (CaCo-2) and breast cancer cells (MCF-7) were treated with elevated doses of ...
Sabit, Hussein, Abdel-Ghany, Shimaa E, Said, Osama A M, Mostafa, Mohamed A, El-Zawahry, Mokhtar   +4 more
openaire   +2 more sources

Mammographic breast density refines Tyrer-Cuzick estimates of breast cancer risk in high-risk women: findings from the placebo arm of the International Breast Cancer Intervention Study I [PDF]

, 2014
Introduction: Mammographic density is well-established as a risk factor for breast cancer, however, adjustment for age and body mass index (BMI) is vital to its clinical interpretation when assessing individual risk.
Howell, Anthony; id_orcid, Jennifer Stone, Cuzick, Jack, Pinney, E, Jane Warwick, Pinney, Elizabeth, Stone, J, Stone, Jennifer, Cuzick, J, Ruth ML Warren, Duffy, Stephen W., Warwick, J, Warren, Ruth ML, Warren, RML, Howell, A, Birke, Hanna, Duffy, SW, Jack Cuzick, Duffy, Stephen W, Bretnall, Adam, Warren, Ruth, Birke, [Unknown], Warwick, Jane, Howell, Anthony, Brentnall, AR, Elizabeth Pinney, Adam R Brentnall, Stephen W Duffy, Anthony Howell, Hanna Birke, Brentnall, Adam R., Birke, H   +31 more
core   +2 more sources

Low SLC8A1 in Colorectal Cancer Dictates Radiotherapy Resistance Through Calcium‐Dependent ANXA2+sEVs Driving M2 Polarization of TAMs

Advanced Science, EarlyView.
SLC8A1 deficiency in colorectal cancer cells increases intracellular calcium signaling, promoting the secretion of ANXA2‐enriched small extracellular vesicles. These vesicles reprogram tumor‐associated macrophages towards an M2 phenotype, which in turn fosters a tumor microenvironment conducive to radioresistance and is associated with poor patient ...
Yimin Fang, Jinghan Zhu, Qian Xiao, Qichun Wei, Xiujing He, Ping Li, Kai Jiang, Yue Liu, Yeting Hu, Weiwei Yu, Chuansheng Guo, Sheng Chen, Jian Zhao, Siqi Dai, Jingsun Wei, Hang Yang, Tongtong Bu, Kefeng Ding, Haiyan Chen   +18 more
wiley   +1 more source

EP-1238: Hypofractionated whole-breast radiotherapy in Italy: A survey by the Breast Cancer Study Group of AIRO

, 2014
Purpose/Objective: In the last two decades a growing interest in the use of hypofractionated whole-breast radiotherapy (RT) for women with early breast cancer has been observed.
VIDALI, CRISTIANA, Breast Cancer Study Group, A. I. R. O., GIUDICI, FABIOLA   +2 more
core   +1 more source

Evaluation of the Survival Benefit of Different Chemotherapy Regimens in Patients with T1-2N0 Triple-Negative Breast Cancer [PDF]

, 2015
PURPOSE: This study aimed to evaluate the survival benefit of different adjuvant chemotherapy regimens in patients with T1-2N0 triple-negative breast cancer.
박세호
core   +1 more source

Organic Nanozyme‐Embedded Biotherapeutic Thermosensitive Hydrogel for Extracellular GSH Depletion and Postoperative Tumor Suppression

Advanced Science, EarlyView.
A temperature‐sensitive hydrogel loaded with cyanine nanozymes and Escherichia coli is locally injected into postoperative tumor resection beds. Upon light irradiation, synergistic PTT and PDT work with cascaded reactive oxygen species to deplete extracellular GSH, eliminate residual tumor cells, and induce robust antitumor immune responses for ...
Cong Jiang, Zifan Yang, Rong Guo, Meng Suo, Guowei Wang, Dong Chen, Lilin Su, Fuhuan Wang, Shipeng Ning, Kelong Fan, Xuan Wang   +10 more
wiley   +1 more source

Targeting the PHB2–ACSL3 Lipid‐Remodeling Axis Overcomes Cisplatin Resistance by Restoring Ferroptosis in Gastric Cancer

Advanced Science, EarlyView.
ABSTRACT Platinum‐based chemotherapy resistance remains a major obstacle in gastric cancer (GC) treatment. Through integrated transcriptomic profiling of cisplatin‐resistant xenografts and pharmacogenomic interrogation of the NCI‐60 dataset, we identified Prohibitin‐2 (PHB2) as a previously unrecognized determinant of chemoresistance.
Liang Xu, Wanying Xiang, Xinyue Wang, Yue Pan, Jing Gao, Jiezhen Yang, Yufei Wang, Zhipu Zhu, Man Tong, Lei Jin, Yan Ye   +10 more
wiley   +1 more source

Advances in Breast Cancer Diagnosis and Treatment in Africa

Biology
Breast cancer remains a significant cause of cancer-related mortality in Africa, where late-stage diagnosis, limited access to specialised care, and underrepresentation in biomedical research continue to impede improvements in patient outcomes.
Anja Piso, Eman Teer, Unathi Ramashala, Claudia du Plessis, Anne Elizabeth Mercier, Anna-Mart Engelbrecht, Iman van den Bout   +6 more
doaj   +1 more source

Report from the 'Eccles' breast screening programme Dublin on epidemiological aspects of screening for breast cancer in Ireland

, 1995
This report outlines the major epidemiological aspects of screening for breast cancer, drawing extensively on experience accrued at the ECCLES Breast Screening Programme over 5 years. It is not an exhaustive account of all aspects of screening.
Codd, Mary B
core  

ZBTB18 Dysfunction Promotes Neuropathic Pain via CHD4‐based Epigenetic Disinhibition of CLIC1 Channels in Sensory Neurons

Advanced Science, EarlyView.
In this study, we identify a novel functional role of ZBTB18 in regulating trigeminal‐mediated neuropathic pain. Nerve injury reduces ZBTB18 in trigeminal ganglion neurons, impairing CHD4/NuRD recruitment and de‐repressing Clic1. Elevated CLIC1 enhances chloride channel activity and neuronal hyperexcitability, thereby driving pain.
Shoupeng Wang, Zitong Huang, Yu Tao, Yunmei Zhang, Yufang Sun, Dongsheng Jiang, Weiwei Lu, Fuhai Ji, Gang Chen, Min Xu, Yuan Zhang, Jin Tao   +11 more
wiley   +1 more source