Results 131 to 140 of about 858,528 (292)

Reshaping Data with the reshape Package [PDF]

This paper presents the reshape package for R, which provides a common framework for many types of data reshaping and aggregation. It uses a paradigm of 'melting' and 'casting', where the data are 'melted' into a form which distinguishes measured and ...
Hadley Wickham
core  

NS1‐Induced PARP1 Phase Transitions Prolongs Host Transcriptional Pausing to Promote Influenza A Virus Replication

Advanced Science, EarlyView.
After IAV infection, NS1 induces PARP1 phase transition, reducing molecular mobility in condensates, prolonging host transcriptional pause, aiding RdRp cap snatching, and promoting viral transcription. ABSTRACT Influenza A virus (IAV) commandeers host transcriptional machinery to replicate, but mechanisms remain elusive.
Shufeng Ma, Changyuan Kang, Xixian Liu, Lichao Yang, Mengyi Li, Yuting Ye, Jianfang Zhang, Yingjun Li, Guanghui Jin, Yang Liu, Xiaohong Chen, Kexin Wang, Zifeng Yang   +12 more
wiley   +1 more source

Light‐Activated Multifunctional Nanoplatforms: Reshaping Combination Therapy to Overcome Multidrug Resistance in Breast Cancer

Small Structures
Multidrug resistance in breast cancer is asignificant clinical challenge that often leads to treatment failure and tumor recurrence. Light‐activated therapies such as photothermal and photodynamic therapies offer spatially and temporally controlled ...
Xianghui Duan, Gangcui Li, Hong Wang, Yanan Zhou, Hai Du, Qin Sun, Fulan Zhao, Luyin Yang, Pan Liang, Wei Ren   +9 more
doaj   +1 more source

Antibody–drug conjugates and immunogenic cell death in breast cancer: agent-specific mechanisms, clinical evidence and translational priorities

Frontiers in Immunology
Antibody–drug conjugates (ADCs) and immune-checkpoint inhibitors (ICIs) are reshaping breast cancer treatment, but the extent to which individual ADCs induce immunogenic cell death (ICD) remains construct specific. Microtubule-inhibitor and topoisomerase
Linghui Fang, Jialu Song, Xiaohui Wang, Fan Wang, Xiaotao Zhu   +4 more
doaj   +1 more source

Integration of the D‐Genome Reshapes Gene Transcription, Chromatin Architecture, and Metabolome of Allohexaploid Wheat, Leading to Enhanced Environmental Adaptability

Advanced Science, EarlyView.
Integration of the D‐genome reshapes gene transcription, chromatin architecture, and the metabolome of hexaploid wheat, leading to enhanced adaptability to salt, UV‐B, and alkali stress. ABSTRACT The hybridization‐led integration of the D‐genome into domesticated tetraploid wheat gave rise to allohexaploid wheat, the most cultivated wheat globally ...
Yanyan Liu, Tao Zhu, Ziru Zhou, Wei Chen, Chao He, Xinkai Zhou, Xin Wang, Chuanye Chen, Bo Yang, Jiaqi Wei, Caixia Lan, Mengmeng Liu, Handong Su, Qiang Li, Xin Hu, Siteng Bi, Weizhi Ouyang, Xingwang Li, Hailiang Mao, Masahiro Kishi, Kerstin Kaufmann, Alisdair R. Fernie, Dijun Chen, Wenhao Yan   +23 more
wiley   +1 more source

Tamoxifen promotes metastasis of breast cancer via reshaping lipid-driven fibrotic microenvironments in the lung

Neoplasia: An International Journal for Oncology Research
Patients with estrogen receptor (ER)-positive breast cancer (BC) remain at risk of distant recurrence for up to 20 years after diagnosis, with an overall recurrence rate of approximately 30%.
Seung-Su Kim, Seungchan An, Sewon Hwang, Hae-Min Kwon, Ga Young Lim, Na-Lee Ka, Minsoo Noh, Mi-Ock Lee   +7 more
doaj   +1 more source

A Video Guide to Reshaping the Breast Through Staged Mastopexy After Nipple-Sparing Mastectomy

Aesthetic Surgery Journal Open Forum
Abstract Nipple-sparing mastectomy (NSM) has gained popularity because of its improved aesthetics and oncological outcomes. This study focuses on staged mastopexy as a technique for optimizing aesthetics in patients with a history of NSM and implant-based reconstruction.
Kelly A Campbell, Kristen Whalen, Nicole K Le, Madison Tyle, William Nicholas Doyle, William West, Timothy Nehila, Lauren Kuykendall   +7 more
openaire   +2 more sources

Dose-Volume Analysis of Lung and Heart according to Respiration in Breast Cancer Patients Treated with Breast Conserving Surgery

, 2012
Purpose: Adjuvant radiotherapy of breast cancer using a photon tangential field incurs a risk of late heart and lung toxicity. The use of free breathing (FB), expiration breath hold (EBH), and deep inspiration breath hold (DIBH) during tangential breast ...
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core   +1 more source

ERα–PADI4–CXCL8 Axis Drives MDSC‐Mediated Immune Evasion in Anaplastic Thyroid Carcinoma

Advanced Science, EarlyView.
MAPK‐driven ligand‐independent ERα activation drives PADI4 transcription and translation. This enzyme then modifies CXCL8 chemokines through citrullination, generating a potent chemoattractant gradient specifically for myeloid‐derived suppressor cells.
Dongdong Zhang, Ying Cai, Junbin Zhang, Jianyong Zhang, Ran Jing, Ming Cai   +5 more
wiley   +1 more source

Tailor-Made Mastopexy Plus Implant, A Safe Journey Toward Breast Reshaping and Augmentation

Aesthetic Plastic Surgery
Augmentation/mastopexy represents one of the most complex procedures in the setting of cosmetic surgery, and there is still an ongoing debate about the most suitable approach to undertake to avoid major complications and deliver the desired result. The present study aims to offer a further contribute to the topic by presenting our personal experience ...
Buccheri, Ernesto Maria, Villanucci, Amedeo, Montemurro, Paolo, Rocco, Nicola, de Vita, Roy   +4 more
openaire   +3 more sources