Results 141 to 150 of about 858,528 (292)

Molecular Landscapes of Tumor Dormancy in Gynecologic Malignancies: From Survival Mechanisms to Precision Interception

Advanced Science, EarlyView.
This Review outlines the biological framework of entry, maintenance, and awakening in dormant minimal residual disease across gynecologic cancers. By mapping critical biological dependencies—from metabolic plasticity to microenvironment interactions—it evaluates novel interception concepts and presents a translational framework combining single‐cell ...
Shih‐Hsuan Cheng, Ren‐Wang Peng, Chang‐Cheng Wu, Chi‐Wen Luo, Emmanuel Naveen Raj, Zhi‐Hong Wen, Tzu‐Hung Hsiao, Chia‐Jung Li   +7 more
wiley   +1 more source

Breast reconstruction techniques with perforator flaps vs other surgical techniques in breast cancer

Introduction: Chest wall perforator flaps are increasingly used as volume replacement techniques in breast-conserving surgery for patients with unfavorable tumor-to-breast ratios or limited remodeling capacity.
Martín Merino Acera, María del Rosario, Colmenarejo García, Esther, Ferrero San Román, Carla, Sánchez Egido, Iris, Valdazo Gómez, Adela, Latorre Marlasca, Lucía, Paseiro Crespo, Gloria Marta   +6 more
core   +1 more source

Social disparity in breast and ovarian cancer incidence in iran, 2003-2009: a time trend province-level study.

, 2013
This pioneering study aimed to investigate social disparities in breast cancer (BC) and ovarian cancer (OC) incidence rates among women across Iran's provinces from 2003 to ...
Ahmad Kiadaliri, Aliasghar, Lund University., Ahmad Kiadaliri, Aliasghar,   +2 more
core   +1 more source

CXCL3 Antagonism Reverses Systemic Antitumor Immune Memory Impairment Associated With High Tumor Burden and Sensitizes Anti‐PD‐1 Therapy

Advanced Science, EarlyView.
This study reveals that large tumors secrete more chemokine CXCL3, which recruits immunosuppressive neutrophils to the periphery, thereby impairing the activation and memory of systemic tumor‑reactive CD8+ T cells. CXCL3 antagonism restores systemic immune memory and enhances the antitumor efficacy of anti‑PD‑1 therapy, offering a potential strategy to
Ji Wang, Xinyu Tang, Zeju Li, Qi Qi, Chang Sun, Wen Sun, Weiya Zhang, Yue Yin, Ya Deng, Peiwen Ling, Yifan Xu, Guangshun Sun, Yi Ren, Hong Pan, Shui Wang, Wenbin Zhou   +15 more
wiley   +1 more source

Neonatal Sevoflurane Exposure Induces Long‐Term Cognitive Impairment via Epigenetically Mediated MMP9 Activation and Perineuronal Net Disruption in the Hippocampal CA2

Advanced Science, EarlyView.
Hippocampal CA2 perineuronal nets ensheathing excitatory pyramidal neurons are selectively vulnerable to repeated neonatal sevoflurane exposure. Epigenetic upregulation of MMP9 via reduced H3K27me3 disrupts PNN integrity, impairs BDNF–TrkB signaling, and causes synaptic protein loss and dendritic spine deficits, leading to persistent social and spatial
Lirong Liang, Jiachen Wang, Taozhi Wang, Yanling Li, Youyi Zhao, Guanghui Hao, Peiqin Gong, Ruling Chen, Yilin Fang, Shengxi Wu, Haopeng Zhang, Hui Zhang   +11 more
wiley   +1 more source

Early‐Life Manganese Overexposure Activates Microglial Phagocytosis through the YY1/TREM2 Axis Leading to Hippocampal Synaptic Remodeling in Mice

Advanced Science, EarlyView.
Early‐life manganese exposure induces behavioral deficits and aberrant hippocampal synaptic remodeling by enhancing microglial phagocytosis in young adult male mice. Mechanistically, manganese promotes Yin Yang 1 (YY1)/triggering receptor expressed on myeloid cells 2 (TREM2) signaling through enhanced HIF1α‐mediated transcription and suppressed SMURF2 ...
Keyu Chen, Bin He, Kuan Liu, Zhuo Ma, Bin Xu   +4 more
wiley   +1 more source

AARS2‐SIRT5‐Driven DLD K445 Lactylation Promotes Cuproptosis Resistance in Glioblastoma Stem Cells

Advanced Science, EarlyView.
Lactylation of DLD at K445 by AARS2 suppresses PDH complex activity and reduces DLAT lipoylation, thereby conferring cuproptosis resistance in glioblastoma stem cells. SIRT5‐mediated delactylation restores PDH function and enhances cuproptosis sensitivity.
Mingtian Ding, Haibiao Xu, Cen Liu, Yangyin Ding, Shuai Wang, Jun Yin, Tao Fu, Xiao Jiang, Yuning Chen, Hui Luo, Rui Li, Zhengxin Chen, Huibo Wang   +12 more
wiley   +1 more source

Oral Combined Probiotics Clostridium butyricum and Akkermansia muciniphila Inhibits the Progression of 4T1 Breast Cancer by Activating Bcl‐2/Bax Pathway

Cancer Medicine
Background Breast cancer is the most common malignant tumor among women. Recent studies have found that gut probiotics and their metabolic products play a significant role in activating the immune system, reshaping the tumor microenvironment, and ...
Xiaowei Li, Dengxiong Hua, Daoyan Wu, Wei Hong, Yingqian Kang, Lei Tang, Qin Yang, Xinxin Wang, Boyan Li, Renmin Li, Zhenghong Chen, Guzhen Cui   +11 more
doaj   +1 more source

Morphology‐Defined Entropy Streams for Random‐Bit Generation and Probabilistic Sampling in Memristor Arrays

Advanced Science, EarlyView.
Au nanoisland morphology defines stochastic high‐resistance‐state transport in Ag/TiO2 memristor arrays, transforming nanoscale structural disorder into a tunable physical entropy resource. Morphology‐controlled field hotspots and reset‐modulated nanogaps generate statistically validated random‐bit streams, which further serve as device‐derived ...
Hyunjun Kim, Da Ye Kim, Noah Jang, Yongho Lee, Byunghun Song, June Soo Kim   +5 more
wiley   +1 more source

The Lived Experience of Suffering by Nigerian Female Breast Cancer Survivors: A Phenomenological Perspective

Journal of Patient Experience
Breast cancer is a significant public health concern globally, and its impact extends beyond physical survival. Survivors often grapple with a myriad of challenges, including psychological distress, social isolation, and financial hardship.
Chinomso Ugochukwu Nwozichi PhD, RN, CMSRN, OCN, FAAN, Margaret Olutosin Ojewale PhD, RN, Omolabake Salako BSN, RN, Deliverance Brotobor MSc, RN, Elizabeth Olaogun MSc, RN   +4 more
doaj   +1 more source