Results 51 to 60 of about 2,528,262 (264)

Rationale and design of a phase II trial of pyrotinib in combination with nab-paclitaxel as adjuvant therapy for N0/N1mi, HER2 + early breast cancer (PHAEDRA)

BMC Cancer, 2022
Background The de-escalation treatment in patients with low-risk HER2-positive early breast cancer (eBC) is an attractive strategy to avoid unnecessary treatment and improve the quality of life of patients.
Changjun Wang, Yidong Zhou, Yan Lin, Feng Mao, Jinghong Guan, Xiaohui Zhang, Songjie Shen, Xuejing Wang, Yanna Zhang, Bo Pan, Ying Zhong, Li Peng, Xi Cao, Ru Yao, Xingtong Zhou, Chi Xu, Ying Xu, Qiang Sun   +17 more
doaj   +1 more source

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

FEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla, Martín M. Ledesma, Santiago A. Behr, Matías A. Pibuel, María L. Palanek, Daniel H. Grasso, Maria N. Garcia, Juan Garona, Silvina L. Lompardía, Elida Álvarez, Daniela L. Papademetrio   +10 more
wiley   +1 more source

Understanding and Mitigating the Risk of Accelerated Biological Aging in Survivors of Cancer: A Scoping Review

Aging and Cancer, EarlyView.
Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi, Emily Herdman, Danielle Westmark, Vijaya R. Bhatt   +3 more
wiley   +1 more source

The evolution of mastectomies in the oncoplastic breast surgery era

, 2013
Over time, surgical techniques have advanced to the point where oncological safety and aesthetic outcomes are the pillars of contemporary breast surgery.
Zucca-Matthes, Gustavo [UNESP], Viera, Rene Aloísio da Costa [UNESP], Manconi, Andrea, Viera, Rene Aloísio da Costa, Matthes, Angelo do Carmo Silva, Matthes, Angelo do Carmo Silva [UNESP], Michelli, Rodrigo Augusto Depieri, Manconi, Andrea [UNESP], Zucca-Matthes, Gustavo, Michelli, Rodrigo Augusto Depieri [UNESP]   +9 more
core   +1 more source

Cracking the Code: Which Ocular Symptoms Predict Dry Eye Signs? Insights From a Large International Sicca Registry

Arthritis Care &Research, EarlyView.
Objective The study aimed to identify symptom‐based predictors of dry eye disease (DED) signs in the Sjögren's International Collaborative Clinical Alliance (SICCA) cohort. Methods We performed a retrospective analysis examining 16 ocular symptoms (most graded 0–4) and artificial tear (AT) use (graded 0–3) as predictors of DED signs (abnormal ocular ...
Pragnya R. Donthineni, Chloe Shields, Rohit Muralidhar, Shreya Bhatt, Alan Baer, Robert Fox, Sara S. McCoy, Anat Galor   +7 more
wiley   +1 more source

Over surgery in breast cancer

, 2017
Breast surgery remains the original and most effective 'targeted' therapy: excision of early cancer is curative and for more advanced disease surgery improves local disease control.
Karakatsanis, Andreas,, MacNeill, Fiona,
core   +1 more source

What Can Be Learnt about Disease Progression in Breast Cancer Dormancy from Relapse Data? [PDF]

, 2013
Breast cancer patients have an anomalously high rate of relapse many years-up to 25 years-after apparently curative surgery removed the primary tumour.
Karen M Page, Alarcón, T, Tomlinson, IP, Page, KM, Lisa Willis (410078), Tomás Alarcón (224873), Ian P. M. Tomlinson (218767), Tomlinson Ian P. M., Karen M. Page (410080), Trevor A Graham, Alison Malcolm R., Alarcón Tomás, Page Karen M., Tomás Alarcón, Malcolm R. Alison (201259), Willis Lisa, Trevor A. Graham (410079), Graham, TA, Alison, MR, Malcolm R Alison, Tomlinson, IPM, Willis, L, Lisa Willis, Graham Trevor A., Ian P M Tomlinson   +24 more
core   +2 more sources

Anorectal Dysfunction in Systemic Sclerosis: Clinical Phenotypes and Functional Patterns

Arthritis Care &Research, EarlyView.
Objective The aim of this study was to characterize specific physiologic defects in anorectal dysfunction in systemic sclerosis (SSc) using anorectal manometry (ARM), evaluate associations with gastrointestinal (GI) and extraintestinal clinical phenotypes, and explore potential serologic markers for risk stratification.
Timothy Kaniecki, Alireza Amindarolzarbi, Tsion Abdi, John Clarke, Michael Hughes, Ami A. Shah, Zsuzsanna H. McMahan   +6 more
wiley   +1 more source

Pembrolizumab response in stage IV luminal-type breast cancer with high microsatellite instability: a case report

Journal of Medical Case Reports
Background Pembrolizumab (PEM), an immune checkpoint inhibitor (ICI), is often used for triple-negative breast cancer, but can also be used to treat solid tumors that exhibit high microsatellite instability (MSI-High).
Keiko Inakami, Noriko Fujita, Chikage Iguchi, Yukie Enomoto, Junya Minohata, Atsushi Sata, Yoshimasa Miyagawa, Tetsu Yanagisawa, Tomokazu Saitoh, Takashi Nomura, Yuka Sawai, Keiko Takahara, Tsutomu Kasugai, Eiichi Shiba   +13 more
doaj   +1 more source

Rheumatoid arthritis, frailty, and outcomes of surgical hospitalizations: A national population‐based analysis

Arthritis Care &Research, Accepted Article.
OBJECTIVE Hospitalization, particularly for surgery, represents a period of heightened stress. We evaluated how frailty attenuates the association of rheumatoid arthritis (RA) with negative health outcomes after elective non‐cardiac surgery. METHODS We conducted a cross‐sectional study using the National Inpatient Sample (2018 to 2020), including ...
Ali Yazdanyar, Joshua Baker, Katherine D Wysham, Mohammed Yousufuddin, Farah Acher Kaiksow, Michael M. Ward   +5 more
wiley   +1 more source