Results 121 to 130 of about 1,131,323 (347)
Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel +10 morewiley +1 more sourcePhenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer +9 morewiley +1 more sourceShifting the limits in wheat research and breeding using a fully annotated reference genome
Science, 2018 R. Appels, K. Eversole, N. Stein, C. Feuillet, B. Keller, J. Rogers, C. Pozniak, F. Choulet, A. Distelfeld, J. Poland, G. Ronen, A. Sharpe, Omer Barad, Kobi Baruch, G. Keeble-Gagnère, M. Mascher, Gil Ben-Zvi, A. Josselin, A. Himmelbach, F. Balfourier, Juan J. Gutierrez-Gonzalez, M. Hayden, C. Koh, G. Muehlbauer, R. Pasam, E. Paux, P. Rigault, J. Tibbits, V. Tiwari, M. Spannagl, D. Lang, H. Gundlach, G. Haberer, K. Mayer, D. Ormanbekova, Verena M. Prade, H. Šimková, T. Wicker, D. Swarbreck, Hélène Rimbert, Marius Felder, N. Guilhot, G. Kaithakottil, J. Keilwagen, P. Leroy, Thomas M. Lux, S. Twardziok, Luca Venturini, A. Juhász, M. Abrouk, I. Fischer, C. Uauy, P. Borrill, R. Ramirez-Gonzalez, D. Arnaud, Smahane Chalabi, B. Chalhoub, A. Cory, R. Datla, M. Davey, J. Jacobs, S. J. Robinson, B. Steuernagel, F. van Ex, B. Wulff, M. Benhamed, A. Bendahmane, L. Concia, D. Latrasse, J. Bartoš, A. Bellec, H. Bergès, J. Doležel, Z. Frenkel, B. Gill, A. Korol, T. Letellier, O. Olsen, Kuldeep Singh, M. Valárik, E. V. D. van der Vossen, S. Vautrin, S. Weining, T. Fahima, Vladimir Glikson, Dina Raats, J. Číhalíková, Helena Toegelová, J. Vrána, P. Sourdille, Benoît Darrier, D. Barabaschi, L. Cattivelli, P. Hernández, Sergio Gálvez, H. Budak, Jonathan D. G. Jones, Kamil Witek, Guotai Yu, I. Small, Joanna Melonek, Ruonan Zhou, T. Belova, K. Kanyuka, R. King, K. Nilsen, Sean Walkowiak, R. Cuthbert, R. Knox, Krystalee Wiebe, D. Xiang, A. Rohde, T. Golds, J. Čížková, B. A. Akpınar, Sezgi Biyiklioglu, Liangliang Gao, Amidou N'Daiye, M. Kubaláková, J. Šafář, Françoise Alfama, A. Adam-Blondon, Raphael Flores, Claire Guerche, M. Loaec, H. Quesneville, J. Condie, J. Ens, Ron Maclachlan, Yifang Tan, A. Alberti, J. Aury, V. Barbe, A. Couloux, C. Cruaud, K. Labadie, S. Mangenot, P. Wincker, G. Kaur, M. Luo, S. Sehgal, P. Chhuneja, O. Gupta, S. Jindal, Parampreet Kaur, Palvi Malik, Priti Sharma, B. Yadav, N. Singh, J. Khurana, Chanderkant Chaudhary, P. Khurana, Vinod Kumar, A. Mahato, S. Mathur, A. Sevanthi, N. Sharma, Ram Sewak Singh Tomar, K. Holušová, O. Plíhal, M. Clark, D. Heavens, George Kettleborough, Jonathan Wright, Barbora Balcárková, Yuqin Hu, E. Salina, N. Ravin, K. Skryabin, A. Beletsky, V. Kadnikov, A. Mardanov, Michail A. Nesterov, A. Rakitin, E. Sergeeva, H. Handa, H. Kanamori, S. Katagiri, F. Kobayashi, S. Nasuda, Tsuyoshi Tanaka, Jianzhon Wu, F. Cattonaro, Min Jiumeng, Karl G. Kugler, M. Pfeifer, S. Sandve, Xu Xun, Bujie Zhan, J. Batley, P. Bayer, D. Edwards, S. Hayashi, Zuzana Tulpová, Paul Visendi, Licao Cui, Xianghong Du, Kewei Feng, Xiaojun Nie, W. Tong, Le Wang +200 moresemanticscholar +1 more sourceDammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh +8 morewiley +1 more source