Results 81 to 90 of about 38,108 (302)
Nuclear Materials and Energy, 2018 In a solid breeding blanket, ceramic breeder pebbles are in contact with reduced activation ferritic martensitic (RAFM) steel at high temperatures for years and accordingly form a corrosion layer on the blanket structural steel.
Keisuke Mukai +3 more
doaj +1 more source
Evaluation of the parfait blanket concept for fast breeder reactors [PDF]
, 1974 "January 1974."Also issued as a Ph. D. thesis by the first author and supervised by the second and third author, MIT, Dept. of Nuclear Engineering, 1974Includes bibliographical references (pages 261-264)An evaluation of the neutronic, thermal-hydraulic ...
Driscoll, Michael J. +2 more
core +2 more sources
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Assessing the risk of proliferation via fissile breeding in ARC-class fusion power plants
Nuclear FusionConstruction of a nuclear weapon requires access to kilogram-scale quantities of fissile material, which can be bred from fertile material like U-238 and Th-232 via neutron capture. Future fusion power plants, with total neutron source rates in excess of
John L. Ball +3 more
doaj +1 more source
Numerical design of the Seed-Blanket Unit for the thorium nuclear fuel cycle
E3S Web of Conferences, 2016 In the paper we present the Monte Carlo modelling by the means of the Monte Carlo Continuous Energy Burn-up Code of the 17x17 Pressurized Water Reactor fuel assembly designed according to the Radkowsky Thorium Fuel concept.
Oettingen Mikołaj, Skolik Katarzyna
doaj +1 more source
Structural assessment of the gripper interlock of the DEMO breeding blanket transporter. [PDF]
Heliyon, 2023 Mozzillo R +4 more
europepmc +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Nuclear FusionThe breeding blanket is a critical component of magnetic confinement fusion reactors. The reliability, availability, maintainability, and inspectability (RAMI) of the blanket has been recognized as a major challenge on the pathway to commercial fusion ...
Qingzhu Liang +4 more
doaj +1 more source