Results 101 to 110 of about 22,173 (305)

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Progress report no. 2 [PDF]

, 1971
Statement of responsibility on title-page reads: Editors: I.A. Forbes, M.J. Driscoll, N.C. Rasmussen, D.D. Lanning and I. Kaplan; Contributors: S.T. Brewer, G.J. Brown, P.DeLaquil, III, M.J. Driscoll, I.A. Forbes, C.W. Forsberg, E.P.
Brewer, Shelby Templeton, Brown, Gilbert Jay, De Laquil, Pascal, Driscoll, Michael J., Forbes, Ian Alexander, Forsberg, Charles Winfield, Gyftopoulos, E. P., Hendrick, Peter Ladd, Kang, Chʻang-sun, Kaplan, Irving, 1912-, Klucar, James Leonard, Lanning, David D., Leung, Timothy Chung-tim, Mason, Edward A. (Edward Archibald), 1924-, Ortiz, Nestor Ruben, Passman, Neil Alan, Rasmussen, Norman C., Rickard, I. C. Massachusetts Institute of Technology, Rogers, V. C. (Vern Child), 1941-, Sullivan, G. E. Massachusetts Institute of Technology, Supple, A. T. Massachusetts Institute of Technology, Tzanos, C. P., Westlake, William James   +22 more
core  

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Fatigue lifetime prediction and reliability assessment for fusion blankets under pulsed operational loading

Nuclear Fusion
The breeding blanket is a critical component of magnetic confinement fusion reactors. The reliability, availability, maintainability, and inspectability (RAMI) of the blanket has been recognized as a major challenge on the pathway to commercial fusion ...
Qingzhu Liang, Xuebin Ma, Xiaoman Cheng, Lei Chen, Songlin Liu   +4 more
doaj   +1 more source

Accelerating the engineering design of breeder blankets with parametric optimisation and sequential learning

Frontiers in Nuclear Engineering
The competing requirements of fusion breeder blankets and the high dimensionality of their design space necessitate a systematic treatment to map the variations in performance against given objective metrics and to understand the operational envelope. In
Luke Humphrey, Helen Brooks, Siddharth Mungale, Andrew Davis, David Foster   +4 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Analysis of a segmentation approach to breeder blanket design and the utilisation of FLiBe as a novel neutron reflector

Nuclear Fusion
Tritium production in a fusion reactor is essential for a deuterium-tritium burning plasma source, and designing a lithium-containing breeder blanket is crucial for a closed fuel cycle in an electricity-to-grid power plant.
Adam J. Barker, Mark R. Gilbert, Philip D. Edmondson   +2 more
doaj   +1 more source

Exhaust assessment of a European Volumetric Neutron Source (EU-VNS) using SOLPS-ITER

Nuclear Materials and Energy
EUROfusion considers a volumetric neutron source (EU-VNS) to generate a neutron wall load of about 0.5MW/m2 to qualify tritium breeding blankets early in support of EU-DEMO that mitigates the risk of a late testing for required nuclear technology.
S. Wiesen, Ch. Bachmann, M. Siccinio, J. Boscary, C. Bourdelle, M. Coleman, G. Federici, F. Maviglia, R. Neu   +8 more
doaj   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source