Results 71 to 80 of about 22,173 (305)

Three-dimensional model of DEMO-FNS facility considering neutronics and radiation shield problems

Heliyon, 2019
Recent neutronics studies of blankets for tokamak-based demonstration fusion neutron source (DEMO-FNS) showed a crucial influence of coolant composition on the transmutation rate of transuranic elements and tritium breeding in the system.
A.V. Zhirkin, B.V. Kuteev
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Conceptual radiation shielding design of the integrated breeding test facility at KFE

Nuclear Engineering and Technology
The Integrated Breeding Test Facility (IBTF) is being developed by Korea Institute of Fusion Energy to assess the long-term performance of breeding blankets under continuous irradiation environment.
Hyoseong Gwon, Dohyun Kim, Seonghee Hong, Mu-Young Ahn   +3 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Searching for exotic scalars at fusion reactors

Journal of High Energy Physics
Part of the energy created in deuterium-tritium fusion reactors is carried away from plasma by a high-intensity neutron flux, which is then absorbed by the reactor’s inner walls.
Chaja Baruch, Patrick J. Fitzpatrick, Tony Menzo, Yotam Soreq, Sokratis Trifinopoulos, Jure Zupan   +5 more
doaj   +1 more source

Tritium Extraction from Liquid Blankets of Fusion Reactors via Membrane Gas–Liquid Contactors

Journal of Nuclear Engineering
The exploitation of fusion energy in tokamak reactors relies on efficient and reliable tritium management. The tritium needed to sustain the deuterium–tritium fusion reaction is produced in the Li-based blanket surrounding the plasma chamber, and ...
Silvano Tosti, Luca Farina
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Evaluation of advanced fast reactor blanket designs [PDF]

, 1977
Originally presented as the first author's thesis, (Sc. D.)--in the M.I.T. Dept. of Nuclear Engineering, 1977Includes bibliographical references (p.
Driscoll Michael J., Shin, Jae In
core  

When Heredity Met the Bacterium: Quarantines in New York and Danzig, 1898-1921 [PDF]

, 2001
[Excerpt] Recent careful examinations of American quarantines placed on incoming migrants have found that health officials were potent carries of bigotries rooted in the larger society; but usually historians have not paid sufficient attention to the ...
Korman, Gerd
core   +2 more sources