Results 71 to 80 of about 22,199 (300)
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Three-dimensional model of DEMO-FNS facility considering neutronics and radiation shield problems
Heliyon, 2019 Recent neutronics studies of blankets for tokamak-based demonstration fusion neutron source (DEMO-FNS) showed a crucial influence of coolant composition on the transmutation rate of transuranic elements and tritium breeding in the system.
A.V. Zhirkin, B.V. Kuteev
doaj +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Conceptual radiation shielding design of the integrated breeding test facility at KFE
Nuclear Engineering and TechnologyThe Integrated Breeding Test Facility (IBTF) is being developed by Korea Institute of Fusion Energy to assess the long-term performance of breeding blankets under continuous irradiation environment.
Hyoseong Gwon +3 more
doaj +1 more source
Evaluation of advanced fast reactor blanket designs [PDF]
, 1977 Originally presented as the first author's thesis, (Sc. D.)--in the M.I.T. Dept. of Nuclear Engineering, 1977Includes bibliographical references (p.
Driscoll Michael J., Shin, Jae In
core
When Heredity Met the Bacterium: Quarantines in New York and Danzig, 1898-1921 [PDF]
, 2001 [Excerpt] Recent careful examinations of American quarantines placed on incoming migrants have found that health officials were potent carries of bigotries rooted in the larger society; but usually historians have not paid sufficient attention to the ...
Korman, Gerd
core +2 more sources
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Searching for exotic scalars at fusion reactors
Journal of High Energy PhysicsPart of the energy created in deuterium-tritium fusion reactors is carried away from plasma by a high-intensity neutron flux, which is then absorbed by the reactor’s inner walls.
Chaja Baruch +5 more
doaj +1 more source
Tritium Extraction from Liquid Blankets of Fusion Reactors via Membrane Gas–Liquid Contactors
Journal of Nuclear EngineeringThe exploitation of fusion energy in tokamak reactors relies on efficient and reliable tritium management. The tritium needed to sustain the deuterium–tritium fusion reaction is produced in the Li-based blanket surrounding the plasma chamber, and ...
Silvano Tosti, Luca Farina
doaj +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source