Results 51 to 60 of about 206,879 (306)
Breeding Designs for Recombinant Inbred Advanced Intercross Lines [PDF]
Genetics, 2008 Abstract Recombinant inbred lines derived from an advanced intercross, in which multiple generations of mating have increased the density of recombination breakpoints, are powerful tools for mapping the loci underlying complex traits. We investigated the effects of intercross breeding designs on the utility of such lines for mapping. The
Matthew V, Rockman, Leonid, Kruglyak
openaire +2 more sources
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Turning the heat up on independent culling in crop breeding
, 2022 Most grain crops are sensitive to heat stress during anthesis which causes substantial reductions in grain yield, and heat stress tolerance (HST) is therefore an important trait for selection in crop breeding programmes during the 21st century.
Li, Li, Cowling, Wallace
core
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Towards F1 Hybrid Seed Potato Breeding
, 2011 Compared to other major food crops, progress in potato yield as the result of breeding efforts is very slow. Genetic gains cannot be fixed in potato due to obligatory out-breeding.
Meijer, D.A. +6 more
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Diallel analysis of maize lines with contrasting responses to applied nitrogen. [PDF]
, 2004 Six S5 lines of maize, previously identified as having contrasting responses to nitrogen (N) supply, were used to carry out a complete series of diallel crosses. The resulting 15 hybrids were grown in a field at two N levels.
Pereira, M. B. +3 more
core
Eradication of scrapie with selective breeding: are we nearly there?
, 2010 Background Following EU decision 2003/100/EC Member States have recently implemented sheep breeding programmes to reduce the prevalence of sheep with TSE susceptible prion genotypes.
Bossers, A. +18 more
core +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
AgricultureIn the face of the global climate and ecological crisis, as well as growing consumer needs and demands, a transformation of the global food production and distribution system is necessary.
Mariusz Nietupski +4 more
doaj +1 more source