Results 121 to 130 of about 1,081 (164)
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Total synthesis of brevetoxin A
Nature, 1998Brevetoxin A is the most potent neurotoxin secreted by Gymnodinium breve Davis, a marine organism often associated with harmful algal blooms known as 'red tides'. The compound, whose mechanism of action involves binding to and opening of sodium channels, is sufficiently toxic to kill fish at concentrations of nanograms per ml and, after accumulation in
K C, Nicolaou +5 more
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Antibodies to brevetoxin B: Serologic differentiation of brevetoxin B and brevetoxin A
Toxicon, 1992A brevetoxin B immunogen was prepared by reacting brevetoxin B with the amino groups of bovine albumin followed by treatment with sodium borohydride. Immunized rabbits produced antibodies that bound [3H]brevetoxin B-alcohol. This binding increased with repeated immunization (KD for one rabbit after three courses of immunization was about 10 pM ...
L, Levine, Y, Shimizu
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2000
Abstract Brevetoxins are lipid-soluble marine poisons synthesized by the red tide dinoflagellate Ptychodiscus brevis (previously Gymnodinium breve). These cyclic polyethers and structural relatives of ciguatoxin may induce massive killings of fish and also cause neurotoxic shell fish poisoning (NSP). NSP is a nonlethal intoxication of
Baden, Daniel G., Adams, David J.
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Abstract Brevetoxins are lipid-soluble marine poisons synthesized by the red tide dinoflagellate Ptychodiscus brevis (previously Gymnodinium breve). These cyclic polyethers and structural relatives of ciguatoxin may induce massive killings of fish and also cause neurotoxic shell fish poisoning (NSP). NSP is a nonlethal intoxication of
Baden, Daniel G., Adams, David J.
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Cardiovascular effects of brevetoxins in dogs
Toxicon, 1985In anesthetized spontaneously breathing dogs, brevetoxin caused dose-dependent periods of apnea and, at high doses, respiratory arrest. In artificially ventilated dogs, i.v. brevetoxin caused complex dose-related cardiovascular changes consisting of: (1) bradycardia; (2) triphasic blood pressure changes, sequentially characterized by depressor/pressor ...
G L, Johnson, J J, Spikes, S, Ellis
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Total Synthesis of Brevetoxin B
Journal of the American Chemical Society, 2005The convergent total synthesis of brevetoxin B (1) has been achieved. The intramolecular allylation of the O,S-acetal 20, prepared from the alpha-chlorosulfide 17 and the alcohol 5, was carried out using AgOTf as a Lewis acid to give the diene 21, predominantly.
Isao, Kadota +3 more
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Absolute configuration of brevetoxins
Journal of the Chemical Society, Chemical Communications, 1986The absolute configuration of the dinoflagellate toxins, brevetoxins, has been unequivocally determined by X-ray crystallography of a chiral dioxolane derivative.
Yuzuru Shimizu +4 more
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Tetrahedron Letters, 1982
Abstract The structure of brevetoxin C (BTX-C), a polyether marine toxin from Ptychodiscus brevis , has been elucidated by comparison of its spectral data with those of brevetoxin B (BTX-B).
Jerzy Golik +3 more
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Abstract The structure of brevetoxin C (BTX-C), a polyether marine toxin from Ptychodiscus brevis , has been elucidated by comparison of its spectral data with those of brevetoxin B (BTX-B).
Jerzy Golik +3 more
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The chemistry of brevetoxins: A review
Toxicon, 1985The structure of the unique 'red tide' dinoflagellate neurotoxin, brevetoxin-B is presented and the experimental data supporting the chemical structure is discussed. A brief account of the other brevetoxins and their structural relationships is also presented.
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Preservation of brevetoxins in Southwest Florida coastal sediments
Harmful Algae, 2022Florida red tide is a natural phenomenon caused by the dinoflagellate, Karenia brevis. Karenia brevis blooms produce potent toxins (brevetoxins) that can cause neurotoxic and respiratory illness in humans and marine life. Red tides were recorded by Spanish explorers as early as the 17th century, however published red tide studies before 1940 are ...
James Javaruski +3 more
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Improved Synthesis of the ABCDE Fragment of Brevetoxin A
Organic Letters, 2006A second-generation synthesis of the BCDE fragment of brevetoxin A is described. Novel reactions were developed that extend the utility of the asymmetric glycolate alkylation reaction and improve scale-up to provide gram quantities of the B and E subunits. Significant improvements to the convergent assembly of the tetracycle were also realized.
Michael T, Crimmins +2 more
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