Comparative Quantitative Proteomic Analysis of High and Low Toxin-Producing Karenia brevis Strains Reveals Differences in Polyketide Synthase Abundance and Redox Status of the Proteome. [PDF]
Mar DrugsTo identify differentially abundant polyketide synthases (PKSs) and to characterize the biochemical consequences of brevetoxin biosynthesis, bottom-up, TMT-based quantitative proteomics and redox proteomics were conducted to compare two strains of the ...
Rein KS +5 more
europepmc +2 more sources
Total Synthesis of Brevetoxin A [PDF]
Organic Letters, 2008 A total synthesis of brevetoxin A is reported. Two tetracyclic coupling partners, prepared from previously reported advanced fragments, were effectively united via a Horner—Wittig olefination. The resulting octacycle was progressed to substrates that were explored for reductive etherification, the success of which led to a penultimate tetraol ...
Michael T, Crimmins +6 more
openaire +4 more sources
Immune Modulating Brevetoxins: Monocyte Cytotoxicity, Apoptosis, and Activation of M1/M2 Response Elements Is Dependent on Reactive Groups. [PDF]
Mar Drugs, 2022 Brevetoxins are a suite of marine neurotoxins that activate voltage-gated sodium channels (VGSCs) in cell membranes, with toxicity occurring from persistent activation of the channel at high doses.
McCall JR +4 more
europepmc +2 more sources
Predicting <i>Karenia brevis</i> Induced Respiratory Irritation at Individual Southwest Florida Beaches Using Cell Abundances Plus Wind Direction and Speed. [PDF]
GeohealthAbstract Nearly annually, blooms of the dinoflagellate Karenia brevis form along the southwest Florida coast leading to a variety of negative impacts, including respiratory irritation (RI) in humans. To limit these impacts, NOAA's National Centers for Coastal Ocean Science (NCCOS) developed a RI model to provide beach‐goers with a category‐based ...
Collins KM +6 more
europepmc +2 more sources
Frontiers in Marine Science, 2021 Exposure of common bottlenose dolphins (Tursiops truncatus) to brevetoxins (PbTx) produced by blooms of the toxic phytoplankton Karenia brevis frequently results in severe health impacts, including illness and large-scale mortality events.
Spencer E. Fire +3 more
doaj +2 more sources
Synthesis of the A-F Fragment of the Pacific Ciguatoxin CTX3C by Iterative Ring-Closing Metathesis and Tsuji-Trost Allylation. [PDF]
Chemistry, 2023 The fully functionalized A−F ring system of the Pacific ciguatoxin CTX3C suitable for coupling to the I−M fragment of the natural product, has been synthesized from a simple glucal derivative. A six‐step sequence that features ring‐closing metathesis and stereoselective palladium‐mediated allylation has been deployed in an iterative manner to construct
Triantafyllakis M +4 more
europepmc +2 more sources
Marine Drugs, 2021 Ciguatera fish poisoning (CFP) and neurotoxic shellfish poisoning syndromes are induced by the consumption of seafood contaminated by ciguatoxins and brevetoxins.
Ophélie Pierre +9 more
doaj +2 more sources
Acute Effects of Brevetoxin-3 Administered via Oral Gavage to Mice
Marine Drugs, 2023 Brevetoxins (BTXs) constitute a family of lipid-soluble toxic cyclic polyethers mainly produced by Karenia brevis, which is the main vector for a foodborne syndrome known as neurotoxic shellfish poisoning (NSP) in humans.
Peggy Barbe +6 more
doaj +2 more sources
Chemiluminescent Receptor Binding Assay for Ciguatoxins and Brevetoxins Using Acridinium Brevetoxin-B2 [PDF]
Toxins, 2019 Ciguatera is the term for poisoning resulting from eating fish from tropical or subtropical regions. The causative toxins collectively named ciguatoxins (CTXs) widely differ in structures depending on their geographic origins, which range from the ...
Kazuya Murata, Takeshi Yasumoto
doaj +3 more sources
Emerging Insights into Brevetoxicosis in Sea Turtles. [PDF]
Animals (Basel)This review summarizes the current understanding of how brevetoxins, produced by Karenia brevis during harmful algal blooms, impact sea turtle health.
Nederlof RA +5 more
europepmc +2 more sources