Results 81 to 90 of about 127 (111)

Brevetoxins: unique polyether dinoflagellate toxins

The FASEB Journal, 1989
Brevetoxins are lipid‐soluble polyether marine toxins of unique structure and pharmacological function. Toxins are active in vivo in the nanomolar to picomolar concentration range and in vitro in isolated neuromuscular or giant axon preparations and in single‐cell or subcellular model systems.
openaire   +2 more sources

Distribution and elimination of brevetoxin PbTx-3 in rats

Toxicon, 1990
After i.v. administration, [3H]PbTx-3 was rapidly cleared from the blood; less than 10% remained after 1 min. Within 30 min, radiolabel distributed to skeletal muscle (69.5%), liver (18.0%), and intestinal tract (8.0%). Over 24 hr, radiolabel decreased in muscle, remained constant in liver, and increased in the intestinal tract and feces.
M A, Poli, C B, Templeton, W L, Thompson, J F, Hewetson   +3 more
openaire   +2 more sources

Brevetoxin binding: molecular pharmacology versus immunoassay

Toxicon, 1988
Brevetoxin PbTx-3 isolated from Florida's red tide dinoflagellate Ptychodiscus brevis has been produced recently in tritiated form by reductive tritiation of brevetoxin PbTx-2. Tritiated PbTx-3 has been used as a specific probe in competitive radioimmunoassays developed to detect brevetoxins in food sources, and this probe has also been utilized to ...
D G, Baden, T J, Mende, A M, Szmant, V L, Trainer, R A, Edwards, L E, Roszell   +5 more
openaire   +2 more sources

Brevetoxins

Brevetoxins (BTXs) are potent marine toxins produced by certain microalgae during harmful algal blooms (HABs). These lipophilic polyether compounds, notably PbTx-1 and PbTx-2, primarily affect seafood safety by bioaccumulating in filter-feeding shellfish and finfish.
openaire   +1 more source

Isolation and structure of a new brevetoxin analog, brevetoxin B2, from greenshell mussels from New Zealand

Tetrahedron, 1998
Abstract A new brevetoxin analog, brevetoxin B2 (BTXB2), was isolated from greenshell mussels, Perna canaliculus, collected at the time of the neurotoxic shellfish poisoning incident in New Zealand. The structure was elucidated based on NMR, CAD FAB MS/MS, and chemical degradation experiments.
Kazuya Murata, Masayuki Satake, Hideo Naoki, Heinrich F. Kaspar, Takeshi Yasumoto   +4 more
openaire   +1 more source

[Ciguatoxins and brevetoxins: dissection of the neurobiological actions].

Journal de la Societe de biologie, 1999
This review focuses on the neurobiological actions of ciguatoxins and brevetoxins which are phycotoxins produced respectively by the dinoflagellates Gambierdiscus toxicus and Ptychodiscus brevis. These actions are illustrated in particular by the effects of the toxins on myelinated nerve fibres and on skeletal neuromuscular junctions of vertebrates ...
Mattei, César, Molgó, Jordi, Legrand, Anne-Marie, Benoit, Evelyne   +3 more
openaire   +2 more sources

Distribution of Brevetoxin (PbTx-3) in Mouse Plasma: Association with High-Density Lipoproteins

Environmental Health Perspectives, 2005
John S Ramsdell
exaly  

Antitoxins to brevetoxin

2023
REIN KATHLEEN S, LIU YUAN
openaire   +1 more source

A Total Synthesis Trilogy: Calicheamicin γ1I, Taxol®, and Brevetoxin A

Chemical Record, 2012
Kyriacos Nicolaou
exaly  

Placental transport of brevetoxin-3 in CD-1 mice

Toxicon, 2006
Janet Benson
exaly