Results 171 to 180 of about 1,079 (195)

Brevetoxins: unique polyether dinoflagellate toxins

The FASEB Journal, 1989
Brevetoxins are lipid‐soluble polyether marine toxins of unique structure and pharmacological function. Toxins are active in vivo in the nanomolar to picomolar concentration range and in vitro in isolated neuromuscular or giant axon preparations and in single‐cell or subcellular model systems.
openaire   +2 more sources

Distribution and elimination of brevetoxin PbTx-3 in rats

Toxicon, 1990
After i.v. administration, [3H]PbTx-3 was rapidly cleared from the blood; less than 10% remained after 1 min. Within 30 min, radiolabel distributed to skeletal muscle (69.5%), liver (18.0%), and intestinal tract (8.0%). Over 24 hr, radiolabel decreased in muscle, remained constant in liver, and increased in the intestinal tract and feces.
M A, Poli, C B, Templeton, W L, Thompson, J F, Hewetson   +3 more
openaire   +2 more sources

Brevetoxin binding: molecular pharmacology versus immunoassay

Toxicon, 1988
Brevetoxin PbTx-3 isolated from Florida's red tide dinoflagellate Ptychodiscus brevis has been produced recently in tritiated form by reductive tritiation of brevetoxin PbTx-2. Tritiated PbTx-3 has been used as a specific probe in competitive radioimmunoassays developed to detect brevetoxins in food sources, and this probe has also been utilized to ...
D G, Baden, T J, Mende, A M, Szmant, V L, Trainer, R A, Edwards, L E, Roszell   +5 more
openaire   +2 more sources

Brevetoxins

Brevetoxins (BTXs) are potent marine toxins produced by certain microalgae during harmful algal blooms (HABs). These lipophilic polyether compounds, notably PbTx-1 and PbTx-2, primarily affect seafood safety by bioaccumulating in filter-feeding shellfish and finfish.
openaire   +1 more source

Isolation and structure of a new brevetoxin analog, brevetoxin B2, from greenshell mussels from New Zealand

Tetrahedron, 1998
Abstract A new brevetoxin analog, brevetoxin B2 (BTXB2), was isolated from greenshell mussels, Perna canaliculus, collected at the time of the neurotoxic shellfish poisoning incident in New Zealand. The structure was elucidated based on NMR, CAD FAB MS/MS, and chemical degradation experiments.
Kazuya Murata, Masayuki Satake, Hideo Naoki, Heinrich F. Kaspar, Takeshi Yasumoto   +4 more
openaire   +1 more source

Chemodiversity of Brevetoxins and Other Potentially Toxic Metabolites Produced by Karenia spp. and Their Metabolic Products in Marine Organisms

Marine Drugs, 2021
Vincent Hort, Eric Abadie, Nathalie Arnich   +2 more
exaly  

Advances in monitoring and toxicity assessment of brevetoxins in molluscan shellfish

Toxicon, 2010
Steven M Plakas, Robert W Dickey
exaly  

Brevetoxins, like ciguatoxins, are potent ichthyotoxic neurotoxins that accumulate in fish

Toxicon, 2007
Leanne J Flewelling, Richard Pierce, Jennifer Wolny   +2 more
exaly  

Type B brevetoxins show tissue selectivity for voltage-gated sodium channels: comparison of brain, skeletal muscle and cardiac sodium channels

Toxicon, 2003
Marie-Yasmine Bottein Dechraoui, John S Ramsdell   +1 more
exaly  

Brevetoxin

2018
openaire   +1 more source