Results 41 to 50 of about 951,547 (299)
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Artificial Neural network-based prediction of SCF at the Intersection of CFST Y-joints
Advances in Bridge Engineering, 2022 Stress concentration factors (SCFs) are used to quantify the hot-spots stress in tubular joints with circular hollow section for fatigue assessment, which are always obtained by finite element analysis or specimens testing.
Lin Xiao +3 more
doaj +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
A Road Map for Civil Engineers towards Bridge Engineering Through Academic Education and Professional Training [PDF]
Civil Engineering Infrastructures Journal, 2017 It is common in many countries that engineers having an academic degree in Civil Engineering are appointed responsible for different tasks related to Bridge Engineering.
Reza Akbari, Shahrokh Maalek
doaj +1 more source
OpenSeesPyView: Python programming-based visualization and post-processing tool for OpenSeesPy
SoftwareX, 2023 This paper presents a newly developed visualization framework called OpenSeesPyView, a Python programming-based graphical user interface (GUI) for OpenSeesPy, a prevalent finite element solver in earthquake engineering.
Junjun Guo +3 more
doaj +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Miki: a wiki for synchronous modeling of software requirements [PDF]
, 2011 Eliciting a high quality requirements model that can be traced down to implementations is a challenge. Keeping models updated for evolving software systems is a further challenge.
Petre, Marian +2 more
core
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Fatigue Crack Calculation of Steel Structure Based on the Improved McEvily Model
Applied Sciences, 2022 Numerous fatigue crack mechanism models have been proposed based on an in-depth study of material fatigue mechanisms and engineering requirements. However, due to many of the parameters in these models being difficult to determine, their application to ...
Zuocao Yu +4 more
doaj +1 more source