Results 51 to 60 of about 147,791 (261)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

CF60 Concrete Composition Design and Application on Fudiankou Xijiang Super Large Bridge

E3S Web of Conferences, 2018
Guangxi Wuzhou City Ring Road Fudiankou Xijiang super large bridge CF60 concrete is a new multi-phase composite high-performance concrete, this paper for the Fudiankou Xijiang bridge structure and characteristics of the project, in accordance with the ...
Qiu Yi Mei, Wen Sen Yuan, Chen Jun Xiang
doaj   +1 more source

Engineering bridging tradition: Ismaili Center Houston

Glass Structures & Engineering
Following London (1985), Vancouver (1985), Lisbon (1998), Dubai (2008), Dushanbe (2009) and Toronto (2014), the Ismaili Center Houston was established in 2025. Commissioned by the Aga Khan, spiritual leader of the Shia Ismaili Muslims, and designed by Farshid Moussavi Architecture, the Center functions as both a place of worship and a venue for ...
Tommaso Baudone, Jonas Hilcken, Felix Schmitt, Ladislaus Balint, Thomas Fritsche   +4 more
openaire   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

PyWindAM: A Python software for wind field analysis and cloud-based data management

SoftwareX
Given the substantial influence of wind loading on the structural performance of long-span bridges, continuous monitoring of wind field characteristics in their vicinity is paramount. PyWindAM is purpose-built web server software meticulously designed to
Nanxi Chen, Rujin Ma, Baixue Ge, Haocheng Chang   +3 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Impact spectra for eccentrically prestressed beam of bending-stretching effect under moving load

Resilient Cities and Structures
In this study, the impact behavior of an eccentrically prestressed simply-supported concrete beam of prophase bending-stretching retention subjected to a constant moving load is investigated for structure impact resilience evaluation.
Md Mahathe Hasan Toha, Zhi Sun, Chuhan Fan, Jianglin Xu   +3 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Dynamic Responses of Long-Span Steel Truss Girder Cable-Stayed Bridge With a Single Pylon

Advances in Civil Engineering
The study investigates the seismic response of long-span single-tower and single-cable steel truss girder cable-stayed bridges, which structurally differ from traditional bridge types, and there is limited research on the influence of cable arrangement ...
Yong Zeng, Jiahao Wei, Yutong Zeng, Yunchuan Xiao, Hongwei Mao, Ming Huang, Zhongfu Xiang, Jianting Zhou   +7 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source