Results 51 to 60 of about 205,705 (314)
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Quantifying Color Variation: Improved Formulas for Calculating Hue with Segment Classification
Applications in Plant Sciences, 2014 Premise of the study: Differences in color form a major component of biological variation, and quantifying these differences is the first step to understanding their evolutionary and ecological importance.
Stacey D. Smith
doaj +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Frontiers in Human Neuroscience, 2015 Research in lightness perception centers on understanding the prior assumptions and processing strategies the visual system uses to parse the retinal intensity distribution (the proximal stimulus) into the surface reflectance and illumination components ...
Barbara eBlakeslee, Mark E McCourt
doaj +1 more source
Utilization of Organic Complex of Glanapone Stab Rather than Sodium Silicate in Peroxide Bleaching of Mixed Hardwood CMP Pulp [PDF]
تحقیقات علوم چوب و کاغذ ایران, 2010 This research was accomplished in order to investigate the replacement of organic complex of Glanapone Stab with sodium silicate on optical properties of hardwood CMP pulp bleached by hydrogen peroxide.
Iman Akbarpour, Hossein Resalati
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source