Results 11 to 20 of about 4,322 (154)

Loss of Consciousness in a Child Following Accidental Ingestion of Brimonidine Ointment: A Case Report. [PDF]

Clin Case Rep
ABSTRACT Brimonidine ingestion in young children can cause rapid, severe central nervous system (CNS) depression, including miosis and hypotonia. Clinicians should maintain a high index of suspicion in toddlers presenting with unexplained drowsiness following exposure.
Zareh Mahmoudabadi R, Vafapour M, Karrobi M, Noori Etemad Z, Mohammadi M, Gholizadeh SR, Mohammadi A.   +6 more
europepmc   +2 more sources

Ocular and Systemic Pharmacokinetics of Brimonidine and Timolol After Topical Administration in Rabbits: Comparison Between Fixed-Combination and Single Drugs

Ophthalmology and Therapy, 2020
Introduction This study was aimed to compare ocular tissue distribution and systemic exposure of brimonidine and timolol after single topical administration to rabbits of fixed-combination ophthalmic solution of 0.1% brimonidine tartrate and 0.5% timolol
Gen Suzuki, Eriko Kunikane, Keisuke Shinno, Seiko Kozai, Masaaki Kurata, Akio Kawamura   +5 more
doaj   +1 more source

Evaluation of brimonidine-timolol fixed combination in patients of primary open-angle glaucoma

Indian Journal of Ophthalmology, 2013
The aim of present study was to compare the efficacy and safety of fixed combination of brimonidine and timolol with individual components used as monotherapy in patients of primary open angle glaucoma.
Sachin R Joshi, Pramod B Akat, Jaiprakash B Ramanand, Sunita J Ramanand, Vitthal B Karande, Suyog S Jain   +5 more
doaj   +1 more source

Neuroprotective properties of Brimonidine

Офтальмохирургия, 2019
Purpose. To summarize relevant data from publications appearing in the peer-reviewed scientific literature since1991 about mechanisms of neurodegeneration in glaucoma and the possibilities of neuroprotection; in particular, analysis of the results of ...
Т. N. Mikhailova
doaj   +1 more source

Genetic Identification of Potential Drug Targets for Dental Caries: A Mendelian Randomization Study. [PDF]

Health Sci Rep
ABSTRACT Background and Aims Dental caries (DC), a chronic and multifactorial disease, affects billions of people globally, posing a significant public health challenge. Despite its prevalence, the molecular mechanisms underlying DC and effective pharmacological targets remain elusive.
Bi J, Liu A, Zhang N, Chen Y, Liu C, Zhu Y, Wen H, Ma C.   +7 more
europepmc   +2 more sources

Effect of Topical Brimonidine 0.15% on Conjunctival Injection after Strabismus Surgery in Children

Journal of Ophthalmology, 2021
Purpose. To investigate the effects of topical brimonidine 0.15% instillation on conjunctival injection after strabismus surgery in children. Methods.
Dong Hyun Kim, Hee Kyung Yang, Sang Beom Han, Jeong-Min Hwang   +3 more
doaj   +1 more source

Nummular keratitis: A rare manifestation of brimonidine allergy

Oman Journal of Ophthalmology
A 32-year-old male, with juvenile open-angle glaucoma on chronic antiglaucoma therapy and recently introduced brimonidine eye drops to the treatment regimen, developed bilateral follicular conjunctivitis with subepithelial infiltrates (SEIs) initially ...
Maitha Al Asmi, Aisha Al Busaidi
doaj   +1 more source

Permeability of the Retina and RPE-Choroid-Sclera to Three Ophthalmic Drugs and the Associated Factors

Pharmaceutics, 2021
In this study, Retina-RPE-Choroid-Sclera (RCS) and RPE-Choroid-Sclera (CS) were prepared by scraping them off neural retina, and using the Ussing chamber we measured the average time–concentration values in the acceptor chamber across five isolated ...
Hyeong Min Kim, Hyounkoo Han, Hye Kyoung Hong, Ji Hyun Park, Kyu Hyung Park, Hyuncheol Kim, Se Joon Woo   +6 more
doaj   +1 more source

Brimonidine-Soluplus Nanomicelles: Preparation and in-vitro evaluation

Iraqi Journal of Pharmaceutical Sciences
Brimonidine is an active pharmaceutical ingredient used to treat glaucoma as a topical eye drop. Ophthalmic topical preparations are associated with low ocular bioavailability due to several physiological and analytical barriers.
Noor Al wiswasi, Fatima J. Al-Gawahri
doaj   +1 more source

Comparisons of efficacy and safety between preserved and preservative-free brimonidine tartrate in glaucoma and ocular hypertension: a parallel-grouped, randomized trial

Scientific Reports, 2023
This multicenter (four institutions), randomized, investigator-masked, parallel-group clinical trial evaluated and compared the efficacy and safety of preservative-free and preserved brimonidine tartrate 0.15% in open-angle glaucoma and ocular ...
Ko Eun Kim, Chang Kyu Lee, Jonghoon Shin, Yuri Kim, Seungsoo Rho   +4 more
doaj   +1 more source