Use of an alternative method to evaluate erythema severity in a clinical trial: difference in vehicle response with evaluation of baseline and postdose photographs for effect of oxymetazoline cream 1·0% for persistent erythema of rosacea in a phase IV study. [PDF]
, 2019 BackgroundOnce-daily topical oxymetazoline cream 1·0% significantly reduced persistent facial erythema of rosacea in trials requiring live, static patient assessments.ObjectivesTo evaluate critically the methodology of clinical trials that require live ...
Alvandi, N +10 more
core +1 more source
Cationic supramolecular hydrogels for overcoming the skin barrier in drug delivery [PDF]
, 2018 A cationic bis‐imidazolium‐based amphiphile was used to form thermoreversible nanostructured supramolecular hydrogels incorporating neutral and cationic drugs for the topical treatment of rosacea.
Amabilino, David B. +6 more
core +1 more source
Cardiovascular effects of timolol maleate, brimonidine or brimonidine/timolol maleate in concomitant therapy [PDF]
Acta Ophthalmologica Scandinavica, 2002 ABSTRACT.Purpose: To examine the influence on maximal exercise performance in young healthy volunteers of timolol 0.5%, brimonidine 0.2% or placebo versus brimonidine 0.2% and timolol 0.5% used concomitantly.Methods: The subjects in this prospective, double‐masked, crossover comparison were dosed 15 min prior to treadmill testing.
Jeanette A. Stewart +2 more
openaire +3 more sources
Evaluation of brimonidine-timolol fixed combination in patients of primary open-angle glaucoma
Indian Journal of Ophthalmology, 2013 The aim of present study was to compare the efficacy and safety of fixed combination of brimonidine and timolol with individual components used as monotherapy in patients of primary open angle glaucoma.
Sachin R Joshi +5 more
doaj +1 more source
Brimonidine 0.2% versus Brimonidine Purite 0.15% in Asian Ocular Hypertension
Journal of Ocular Pharmacology and Therapeutics, 2007 The aim of this study was to evaluate the efficacy and safety of brimonidine 0.2% versus brimonidine Purite 0.15% in Asians with ocular hypertension.This study was a prospective, randomized, observer-masked, short-term crossover trial. Eighty-six (86) Asian subjects with newly diagnosed ocular hypertension were randomly assigned to receive either ...
Chan Yun Kim, Gong Je Seong, Samin Hong
openaire +4 more sources
Formulation and Physicochemical Characterization of Magnetic Nanoparticles Containing Brimonidine for Ophthalmic Drug Delivery [PDF]
, 2018 Introduction: Recently, magnetic nanoparticles (MNPs) drew a great attention for application in drug delivery systems. Due to their biocompatibility and non-toxic properties, they have potential to create versatile drug delivery systems.
Afsharipour, Sepehr +4 more
core +2 more sources
A COMPARATIVE STUDY OF DORZOLAMIDE + TIMOLOL VS. BRIMONIDINE + TIMOLOL FIXED COMBINATION THERAPY IN THE MANAGEMENT OF PRIMARY OPEN ANGLE GLAUCOMA [PDF]
, 2017 Background: To compare the efficiency of dorzolamide + timolol fixed combination vs. the Brimonidine + timolol fixed combination in the management of primary open-angle glaucoma Materials and methods: A prospective study conducted over a period
Ramniklal Savalia, Pratik
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Effect of Topical Brimonidine 0.15% on Conjunctival Injection after Strabismus Surgery in Children
Journal of Ophthalmology, 2021 Purpose. To investigate the effects of topical brimonidine 0.15% instillation on conjunctival injection after strabismus surgery in children. Methods.
Dong Hyun Kim +3 more
doaj +1 more source
Pharmaceutics, 2021 In this study, Retina-RPE-Choroid-Sclera (RCS) and RPE-Choroid-Sclera (CS) were prepared by scraping them off neural retina, and using the Ussing chamber we measured the average time–concentration values in the acceptor chamber across five isolated ...
Hyeong Min Kim +6 more
doaj +1 more source
A comparative study on safety and efficacy of travoprost and brimonidine/timolol fixed combination in patients of primary open angle glaucoma [PDF]
, 2016 Background: The purpose of this study was to compare and evaluate the clinical efficacy of topically applied travoprost 0.004% eye drops versus brimonidine/timolol fixed combination eye drops in the management of primary open-angle glaucoma.Methods: In ...
Gupta, Saroj +3 more
core +2 more sources