Results 51 to 60 of about 10,864 (278)

Permeability of the Retina and RPE-Choroid-Sclera to Three Ophthalmic Drugs and the Associated Factors

Pharmaceutics, 2021
In this study, Retina-RPE-Choroid-Sclera (RCS) and RPE-Choroid-Sclera (CS) were prepared by scraping them off neural retina, and using the Ussing chamber we measured the average time–concentration values in the acceptor chamber across five isolated ...
Hyeong Min Kim, Hyounkoo Han, Hye Kyoung Hong, Ji Hyun Park, Kyu Hyung Park, Hyuncheol Kim, Se Joon Woo   +6 more
doaj   +1 more source

Upper limits of intraocular pressure in glaucoma clinical trials [PDF]

, 2015
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/110560/1/ceo12357 ...
DeMill, David L, Nelson, Lindsay A, Stewart, William C, Wirostko, Barbara M   +3 more
core   +1 more source

Sustained release of brimonidine from BRI@SR@TPU implant for treatment of glaucoma

Drug Delivery, 2022
Glaucoma is the leading cause of irreversible vision loss worldwide, and reduction of intraocular pressure (IOP) is the only factor that can be interfered to delay disease progression.
Yujin Zhao, Chang Huang, Zhutian Zhang, Jiaxu Hong, Jianjiang Xu, Xinghuai Sun, Jianguo Sun   +6 more
semanticscholar   +1 more source

Where does selective laser trabeculoplasty stand now? A review [PDF]

, 2016
Background: Chronic treatment of glaucoma can present a challenge in patients who lack the means and/or the discipline to use daily glaucoma medication. We wondered if selective laser trabeculoplasty (SLT) could be a useful alternative.
De Belder, Maya, De Belder, Simon, De Groot, Veva, De Keyser, Myrjam   +3 more
core   +2 more sources

A Single Drop in the Eye – Effects on the Whole Body [PDF]

, 2017
Peer ...
Vaajanen, Anu, Vapaatalo, Heikki
core   +2 more sources

A pharmacoeconomic analysis to determine the relative cost-effectiveness of bimatoprost 0.03% eye drops and brimonidine 0.2% eye drops in patients of primary open-angle glaucoma/ocular hypertension

Indian Journal of Ophthalmology, 2014
Aims: The aim was to compare efficacy and cost-effectiveness of bimatoprost 0.03% and brimonidine 0.2% in primary open-angle glaucoma (POAG)/ocular hypertension (OHT). Settings and Design: Open, randomized, cross-over, comparative study.
Navreet Kaur Natt, A Gupta, G Singh, T Singh   +3 more
doaj   +1 more source

Use of an alternative method to evaluate erythema severity in a clinical trial: difference in vehicle response with evaluation of baseline and postdose photographs for effect of oxymetazoline cream 1·0% for persistent erythema of rosacea in a phase IV study. [PDF]

, 2019
BackgroundOnce-daily topical oxymetazoline cream 1·0% significantly reduced persistent facial erythema of rosacea in trials requiring live, static patient assessments.ObjectivesTo evaluate critically the methodology of clinical trials that require live ...
Alvandi, N, Baldwin, HE, Del Rosso, JQ, Eichenfield, LF, Harper, J, Hebert, AA, Kaoukhov, A, Kircik, LH, Stein-Gold, L, Tan, JKL, Webster, GF   +10 more
core   +1 more source

A computerized analysis of the entire retinal ganglion cell population and its spatial distribution in adult rats [PDF]

, 2008
In adult albino (SD) and pigmented (PVG) rats the entire population of retinal ganglion cells (RGCs) was quantified and their spatial distribution analyzed using a computerized technique. RGCs were back-labelled from the optic nerves (ON) or the superior
Salinas-Navarro, M., Mayor-Torroglosa, S., Jiménez-López, M., Avilés-Trigueros, M., Holmes, T.M., Lund, R.D., Villegas-Pérez, M.P., Vidal-Sanz, M.   +7 more
core   +1 more source

Axonal protection by combination of ripasudil and brimonidine with upregulation of p-AMPK in TNF-induced optic nerve degeneration

International ophtalmology
Purpose The ROCK inhibitor ripasudil hydrochloride hydrate was shown to have axonal protective effects in TNF-induced optic nerve degeneration. The α2-adrenoreceptor agonist brimonidine was also shown to exert axonal protection.
Mizuki Otsubo, Kana Sase, Chihiro Tsukahara, Naoki Fujita, Ibuki Arizono, Naoto Tokuda, Y. Kitaoka   +6 more
semanticscholar   +1 more source

Brimonidine Modulates the ROCK1 Signaling Effects on Adipogenic Differentiation in 2D and 3D 3T3-L1 Cells

Bioengineering, 2022
The additive effects of an α2-adrenergic agonist, brimonidine (BRI), on the pan-ROCK inhibitor (ROCK-i), ripasudil (Rip), and the ROCK2-I, KD025, on adipogenic differentiation (DIF+) were examined using two- or three-dimension (2D or 3D) cultures of 3T3 ...
Araya Umetsu, Yosuke Ida, Tatsuya Sato, Megumi Watanabe, Yuri Tsugeno, M. Furuhashi, Fumihito Hikage, H. Ohguro   +7 more
semanticscholar   +1 more source