Results 91 to 100 of about 1,511 (168)

Exploring data‐driven chemical SMILES tokenization approaches to identify key protein–ligand binding moieties

Molecular Informatics, Volume 43, Issue 3, March 2024.
Abstract Machine learning models have found numerous successful applications in computational drug discovery. A large body of these models represents molecules as sequences since molecular sequences are easily available, simple, and informative. The sequence‐based models often segment molecular sequences into pieces called chemical words, analogous to ...
Asu Busra Temizer, Gökçe Uludoğan, Rıza Özçelik, Taha Koulani, Elif Ozkirimli, Kutlu O. Ulgen, Nilgun Karali, Arzucan Özgür   +7 more
wiley   +1 more source

Efficacy and safety of combination therapy with latanoprost after a change in therapeutic regimen from timolol to brinzolamide in Japanese adult patients with primary open-angle glaucoma and ocular hypertension: open, non-randomized 12-week study

Clinical Ophthalmology, 2008
Shusaku Ishikawa1, Yoshimi Nakamura1, Yuko Nakamura1, Hiroshi Sakai1, Shoichi Sawaguchi1, Kazuo Terashima2, Makoto Kanno2, Hidetoshi Yamashita21Department of Ophthalmology, University of the Ryukyus Faculty of Medicine, Okinawa, Japan; 2Department of ...
Shusaku Ishikawa, Yoshimi Nakamura, Yuko Nakamura, Hiroshi Sakai, Shoichi Sawaguchi, et al   +5 more
doaj  

Effects of Antiglaucoma Drugs on Calcium Mobility in Cultured Corneal Endothelial Cells

Kaohsiung Journal of Medical Sciences, 2006
The aim of this study was to estimate the effects of various antiglaucoma drugs including betaxolol, timolol, levobunolol, brimonidine, carteolol, dipivefrin, dorzolamide, brinzolamide, latanoprost, unoprostone, and pilocarpine on intracellular free Ca2+
Kwou-Yeung Wu, Show-Jen Hong, Hwei-Zu Wang   +2 more
doaj   +1 more source

Gene Expression Signature-Based Screening Identifies New Broadly Effective Influenza A Antivirals [PDF]

, 2010
Classical antiviral therapies target viral proteins and are consequently subject to resistance. To counteract this limitation, alternative strategies have been developed that target cellular factors.
Bruno Lina, Béatrice Loriod, Catherine N'Guyen, Jean-Jacques Diaz, Julien Textoris, Laurence Josset, Man-Seong Park, Manuel Rosa-Calatrava, Olivier Ferraris, Vincent Moules   +9 more
core   +5 more sources

Addition of a fixed combination of brinzolamide 1%/timolol 0.5% to prostaglandin monotherapy in patients with glaucoma or ocular hypertension

Clinical Ophthalmology, 2011
Katrin Lorenz1, Klaus Rosbach2, Andreas Matt3, Norbert Pfeiffer11University Medical Center, Johannes Gutenberg-Universität Mainz, Mainz, Germany; 2Private practice, Mainz, Germany; 3Private practice, Köln-Hohenhaus, GermanyBackground ...
Lorenz K, Rosbach K, Matt A, Pfeiffer N
doaj  

Effect of prophylactic intraocular pressure-lowering medication (brinzolamide) on intraocular pressure after ranibizumab intravitreal injection: A case–control study

Indian Journal of Ophthalmology, 2016
Purpose: To observe the effect of prophylactic intraocular pressure (IOP)-lowering medication (brinzolamide) on IOP after ranibizumab intravitreal injections (IVIs).
Shuang Song, Xiao-bing Yu, Hong Dai
doaj   +1 more source

Travoprost Induced Granulomatous Anterior Uveitis [PDF]

, 2011
Purpose. To report a case of granulomatous anterior uveitis caused by travoprost. Methods. Single observational case report. Results. A 71-year-old who was fit and healthy presented with bilateral granulomatous anterior uveitis 2 months after he was ...
Chiam, Patrick
core   +3 more sources

Experience in Application of the Combinations Dorzolamide / Timolol and Brinzolamide / Timolol for the Prevention of Intraocular Hypertension in Patients with Silicone Oil Tamponade of the Vitreal Cavity

Oftalʹmologiâ
Purpose: to conduct a comparative analysis of the clinical efficacy of a fixed combination of antihypertensive drugs: brinzolamide 1 % = timolol 0.5 % and dorzolamide 2 % = timolol 0.5 % for the prevention of intraocular hypertension in patients with ...
A. N. Kazennov, A. D. Chuprov, I. A. Kazennova, A. S. Firsov   +3 more
doaj   +1 more source

How latanoprost changed glaucoma management [PDF]

, 2023
Glaucoma is currently considered one of the leading causes of severe visual impairment and blindness worldwide. Topical medical therapy represents the treatment of choice for many glaucoma patients.
Cordeiro, Maria Francesca, Gandolfi, Stefano, Gugleta, Konstantin, Normando, Eduardo M, Oddone, Francesco   +4 more
core  

A comparative evaluation of efficiency of fixed combination hypotensives for the treatment of primary open-angle glaucoma

Российский офтальмологический журнал, 2018
Purpose. To compare hypotensive efficiency and safety of fixed combinations of drugs treating primary open-angle glaucoma (POAG). Material and methods.
F. A. Bakhritdinova, S. Sh. Mirrakhimova, U. R. Karimov, A. . Khera   +3 more
doaj   +1 more source