Results 71 to 80 of about 3,304 (220)

Sauteur d'Alfort rabbit‐like locomotory disturbances and eye disorders in two pet rabbits—‘handstand rabbits’

Veterinary Record Case Reports, Volume 13, Issue 3, September 2025.
Abstract Homozygous sauteur d'Alfort rabbits have a splicing‐site mutation in the RAR‐related orphan receptor B (RORB) gene that causes changes in their locomotion. These rabbits sometimes walk on their thoracic limbs, especially at higher speeds. They also experience additional abnormalities, including eye alterations such as blindness due to retinal ...
Kerstin Müller, Sabine Schulze, Katharina Thieme, Robert Klopfleisch, Miguel Carneiro   +4 more
wiley   +1 more source

Brinzolamide ophthalmic suspension: a review of its pharmacology and use in the treatment of open angle glaucoma and ocular hypertension

Clinical Ophthalmology, 2008
Michele IesterClinica Oculistica, University of Genoa, ItalyAbstract: Brinzolamide is a white powder commercially formulated as a 1% ophthalmic suspension to reduce intraocular pressure (IOP).
Michele Iester
doaj  

Representation learning of drug and disease terms for drug repositioning

, 2017
Drug repositioning (DR) refers to identification of novel indications for the approved drugs. The requirement of huge investment of time as well as money and risk of failure in clinical trials have led to surge in interest in drug repositioning.
Anand, Ashish, Manchanda, Sahil
core   +1 more source

A prospective 3-year follow-up trial of implantation of two trabecular microbypass stents in open-angle glaucoma [PDF]

, 2015
PURPOSE: To evaluate 3-year safety and intraocular pressure (IOP) following two trabecular microbypass stents in phakic and pseudophakic subjects with open-angle glaucoma (OAG) not controlled on preoperative medication.
David Chang, Eric Donnenfeld, Iqbal Ike Ahmed, Jane Ellen Giamporcaro, Kerry Solomon, L. Jay Katz, Lilit Voskanyan, Thomas Samuelson   +7 more
core   +3 more sources

Incidence of postoperative retinal detachment and bacterial endophthalmitis in the Swedish national paediatric cataract register and associated risk factors

Acta Ophthalmologica, Volume 103, Issue 5, Page 561-570, August 2025.
Abstract Purpose To investigate the incidence and risk factors of retinal detachment (RD) and bacterial endophthalmitis in a cohort of children who underwent cataract surgery before the age of eight. Methods Data was retrieved from the Swedish national paediatric cataract register.
Arzu Seyhan Karatepe Hashas, Anna Linnarsson Wiklund, Jenny Gyllén, Birgitte Haargaard, Gunilla Magnusson, Alf Nyström, Kristina Tornqvist, Eric Trocmé, Ulrika Kjellström   +8 more
wiley   +1 more source

Evaluation of Antioxidant and Enzyme Inhibition Properties of Siran Propolis: Correlations With Phenolic Content Determined by LC–MS/MS

Food Science &Nutrition, Volume 13, Issue 7, July 2025.
The ethanolic extract of Şiran propolis exhibited strong antioxidant activity and inhibited α‐glycosidase, AChE, and human carbonic anhydrase isozymes I and II. High levels of phenolic acids, especially p‐coumaric and ferulic acids, correlated with its bioactivity.
Neslihan Balci, Kubra Aslan, Adem Erturk, Ilhami Gulcin   +3 more
wiley   +1 more source

Efficiency, safety, and patient preference of switching from dorzolamide 1%/timolol 0.5% to brinzolamide 1%/timolol 0.5% while maintaining the prostaglandin F2α analog

Clinical Ophthalmology, 2015
Yoshie Shimizu,1 Shunsuke Nakakura,1 Makiko Nishiyama,1 Hitoshi Tabuchi,1 Yoshiaki Kiuchi2 1Department of Ophthalmology, Saneikai Tsukazaki Hospital, Himeji, 2Department of Ophthalmology and Visual Sciences, Graduate School of Biomedical Sciences ...
Shimizu Y, Nakakura S, Nishiyama M, Tabuchi H, Kiuchi Y   +4 more
doaj  

TRIPS implementation and secondary pharmaceutical patenting in Brazil and India [PDF]

, 1978
This article compares national approaches toward secondary pharmaceutical patents. Because secondary patents can extend periods of exclusivity and delay generic competition, they can raise prices and reduce access to medicines. Little is known about what
Bhaven N. Sampat, Kenneth C. Shadlen, T Amin, M Basso, ER Berndt, P Drahos, P Drahos, R Falvey, R Falvey, J Farrell, KM Gopakumar, CS Hemphill, CS Hemphill, CS Hemphill, L Howard, O Ivus, A Kapczynski, A Kapczynski, VYM Kunisawa, MK Kyle, S La Croix, M Lemley, M Liu, J-F Morin, WG Park, Y Qian, BN Sampat, FM Scherer, A Sengupta, KC Shadlen, KC Shadlen, CM Sweet, N Vernaz   +32 more
core   +1 more source

Nanoparticle Therapeutics in Clinical Perspective: Classification, Marketed Products, and Regulatory Landscape

Small, Volume 21, Issue 29, July 24, 2025.
This review presents a detailed overview of clinically approved nanoparticle therapeutics, classifying them by type and discussing their unique advantages in drug delivery. It highlights regulatory challenges across global markets and emphasizes the need for adaptive approval pathways.
Nimeet Desai, Dhwani Rana, Mitali Patel, Neha Bajwa, Rajendra Prasad, Lalitkumar K. Vora   +5 more
wiley   +1 more source

Patient perspectives when switching from Cosopt® (dorzolamide-timolol) to Azarga™ (brinzolamide-timolol) for glaucoma requiring multiple drug therapy

Clinical Ophthalmology, 2012
Graham Anthony Auger, Mathew Raynor, Simon LongstaffOphthalmology Department, Royal Hallamshire Hospital, Sheffield, South Yorkshire, United KingdomBackground: This study aimed to determine the impact of switching patients requiring multiple drug ...
Auger GA, Raynor M, Longstaff S
doaj