Results 61 to 70 of about 2,319 (150)

Evolving Real‐World Data and Evidence Use for New Drugs and Regenerative Medical Products Approvals in Japan—An Analysis of the 6‐Year Trend

Clinical Pharmacology &Therapeutics, Volume 118, Issue 6, Page 1405-1421, December 2025.
Several regulatory initiatives have been made to clarify the acceptability and requirements of real‐world data and real‐world evidence (RWD/E) for the benefit/risk assessment of new medical products in Japan. The objectives of this review were to characterize the use of RWD/E in regulatory applications of new medical products and to describe the ...
Suguru Okami, Kako Shimotsumagari, Yasunari Sadatsuki   +2 more
wiley   +1 more source

Efficiency, safety, and patient preference of switching from dorzolamide 1%/timolol 0.5% to brinzolamide 1%/timolol 0.5% while maintaining the prostaglandin F2α analog

Clinical Ophthalmology, 2015
Yoshie Shimizu,1 Shunsuke Nakakura,1 Makiko Nishiyama,1 Hitoshi Tabuchi,1 Yoshiaki Kiuchi2 1Department of Ophthalmology, Saneikai Tsukazaki Hospital, Himeji, 2Department of Ophthalmology and Visual Sciences, Graduate School of Biomedical Sciences ...
Shimizu Y, Nakakura S, Nishiyama M, Tabuchi H, Kiuchi Y   +4 more
doaj  

The Concise Guide to PHARMACOLOGY 2025/26: Enzymes

British Journal of Pharmacology, Volume 182, Issue S1, Page S307-S403, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Doriano Fabbro, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Stephanie Annett, Detlev Boison, Kathryn Elisa Burns, Carmen Dessauer, Jürg Gertsch, Nuala Ann Helsby, Angelo A. Izzo, Rennolds Ostrom, Ester Pagano, Andreas Papapetropoulos, Nigel J. Pyne, Susan Pyne, Tracy Robson, Roland Seifert, Johannes‐Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts, Szu Shen Wong   +31 more
wiley   +1 more source

Patient perspectives when switching from Cosopt® (dorzolamide-timolol) to Azarga™ (brinzolamide-timolol) for glaucoma requiring multiple drug therapy

Clinical Ophthalmology, 2012
Graham Anthony Auger, Mathew Raynor, Simon LongstaffOphthalmology Department, Royal Hallamshire Hospital, Sheffield, South Yorkshire, United KingdomBackground: This study aimed to determine the impact of switching patients requiring multiple drug ...
Auger GA, Raynor M, Longstaff S
doaj  

A comparative study on the efficacy of brinzolamide/timolol versus brinzolamide/brimonidine fixed drug combinations in primary open-angle glaucoma

Future Journal of Pharmaceutical Sciences, 2020
Background To compare the efficacy of brinzolamide 1%/timolol 0.5% fixed drug combination (BTFC) with brinzolamide 1%/brimonidine 0.2% fixed drug combination (BBFC) among the patients with primary open-angle glaucoma (POAG).
Sudeepthi Padala, Ramam Sripada, Srivalli Bhaskari Padmavathi Gundabattula, Krishna Jyothi Tadi, Prabhakar Rao Nallamothula, Farzaneh Raveshi, Dasaratha Dhanaraju Magharla   +6 more
doaj   +1 more source

Treatment With Remdesivir Alone or in Combination With GS‐441524 in Cats With Ocular Involvement of Feline Infectious Peritonitis: An Observational Case Series

Journal of Veterinary Internal Medicine, Volume 39, Issue 6, November/December 2025.
ABSTRACT Background Remdesivir and GS‐441524 have successfully treated cats with feline infectious peritonitis (FIP) but the changes in associated signs of ocular disease are not reported. Objective Evaluate the response of FIP‐associated signs of ocular disease before and after treatment with remdesivir, GS‐441524, or both.
Amy L. M. M. Andrews, Eneko Izaguirre, Jodie Green, Emma Scurrell, Savina Gogova, Sarah Tayler, Christiane Kafarnik   +6 more
wiley   +1 more source

Quantitation of brinzolamide in dried blood spots by a novel LC-QTOF-MS/MS method

, 2016
In the current study, a rapid and sensitive LC-QTOF-MS/MS method for the determination of brinzolamide in dried blood spots (DBS) was developed and validated.
Knežević, Miroslav, Loukas, Yannis L., Kostić, Nada, Dotsikas, Yannis, Malenović, Anđelija, Božić, Marija, Foivas, Anargyros   +6 more
core   +3 more sources

Efficacy, Tolerability and Adverse Effects of Triple Fixed Dose Combination Brimonidine–Brinzolamide–Timolol Ophthalmic Suspension in Primary Open Angle Glaucoma: A Retrospective Study

Delhi Journal of Ophthalmology
Purpose: To evaluate the efficacy and tolerability of recently introduced triple fixed dose combination (TFC) of brimonidine–brinzolamide–timolol (BBTFC) in patients with primary open angle glaucoma (POAG).
Hina Kounsar, Swati Singh, Harsh Kumar
doaj   +1 more source

Effects of intracameral tissue plasminogen activator injection on posterior capsular opacification, fibrin formation, and intraocular pressure in dogs after phacoemulsification

Veterinary Ophthalmology, Volume 28, Issue 6, Page 917-925, November 2025.
Abstract Objective To evaluate whether intracameral tissue plasminogen activator (tPA) injection is effective in regulating posterior capsular opacification (PCO), fibrin formation and intraocular pressure (IOP) after cataract surgery. Animal Studied Prospective study involving 30 eyes of 21 dogs that underwent phacoemulsification.
Kyulee Kim, Young‐Sun Kang, Joon Young Kim   +2 more
wiley   +1 more source

A comparative study on efficacy of fixed combination timolol/brinzolamide versus travoprost monotherapy in drug-naïve open-angle glaucoma patients

Therapeutic Advances in Ophthalmology, 2020
Background: Glaucoma is most common irreversible cause of blindness in India. First line management of open-angle glaucoma is either beta blockers or prostaglandin analogs monotherapy.
Alok Dixit, Atul Ashish, Reena Sharma
doaj   +1 more source