Results 41 to 50 of about 3,304 (220)

Gas-phase acidity of sulfonamides: implications for reactivity and prodrug design [PDF]

, 2005
A computational study at the density functional theory level was performed on bioactive and model sulfonamides with the aim of determining the factors affecting the acidity of the sulfonamido group.
Gomes, JRB, Gomes, P
core   +1 more source

Ultrasonographic Appearance of a Posterior Lenticonus in a Cat

Veterinary Ophthalmology, Volume 29, Issue 1, January 2026.
ABSTRACT The objective of this study is to present high‐quality and up‐to‐date ocular ultrasonographic images and videos of a posterior lenticonus with concomitant mature cataract in a cat. Additionally, the clinical findings, surgical treatment, and outcome are reported for completeness and to confirm the diagnosis.
Antonella Rampazzo, Marc Orts‐Porcar, Francesca Del Chicca   +2 more
wiley   +1 more source

Toxicity and Physiological Actions of Carbonic Anhydrase Inhibitors to Aedes aegypti and Drosophila melanogaster

Insects, 2016
The physiological role of carbonic anhydrases in pH and ion regulation is crucial to insect survival. We examined the toxic and neurophysiological effects of five carbonic anhydrase inhibitors (CAIs) against Aedes aegypti.
Sheena A. M. Francis, Jennina Taylor-Wells, Aaron D. Gross, Jeffrey R. Bloomquist   +3 more
doaj   +1 more source

ANIDRASI CARBONICA:SINTESI DI SOLFONAMMIDI BENZOTIOPIRANO-PIRIMIDINICHE QUALI POTENZIALI INIBITORI ISOFORMA SELETTIVI [PDF]

, 2015
Le anidrasi carboniche (CA) sono una superfamiglia di metallo-enzimi che catalizzano l’interconversione tra anidride carbonica e ione bicarbonato. Ad oggi sono conosciute cinque distinte famiglie genetiche di diversa evoluzione: α-CA, β-CA, γ-CA, δ-CA e ...
PESCAGLINI, SARA
core  

Regioselective Access to Sultam Motifs through Cobalt-Catalyzed Annulation of Aryl Sulfonamides and Alkynes using an 8-Aminoquinoline Directing Group [PDF]

, 2015
The use of cobalt as catalyst in direct C[BOND]H activation protocols as a replacement for more expensive second row transition metals is currently attracting significant attention.
Ackermann, Ackermann, Ackermann, Andou, Beletskaya, Bernini, Casitas, Chen, Collins, Corbet, Daugulis, De Santis, Ding, Dong, Gensch, Godula, Grigorjeva, Grigorjeva, Grigorjeva, Guimond, He, Huestis, Hummel, Hyster, Ikemoto, Jia, Jiménez-Hopkins, Kajita, Kaneko, Larock, Lee, Li, Li, Li, Liu, Liu, Lombardino, Lyons, Ma, Majumdar, Merten, Morimoto, Mousseau, Pawar, Pham, Punji, Rakshit, Rassadin, Shah, Shi, Shilov, Shuklov, Song, Song, Stuart, Stuart, Sun, Sun, Suzuki, Tasker, Ueura, Ueura, Umeda, Wells, Wencel-Delord, Wendlandt, Wu, Wu, Wu, Wu, Wu, Yamaguchi, Yeung, Yoshino, Yu, Zhang, Zhang, Zhang, Zhao   +78 more
core   +1 more source

Euler and Gourava Sombor Coindices Bounds and Python‐Based QSPR Modeling for Butane Derivatives and Ocular Pharmaceuticals

Journal of Chemistry, Volume 2026, Issue 1, 2026.
Topological indices are crucial in modeling of molecular structures of graphs and are also useful in correlation with physicochemical properties. In this paper, we propose the Euler Sombor coindex and Gourava Sombor coindex, and we derive bounds by using some graph invariants of a graph such as the degree of a vertex, the order, and the size of a graph.
Suha Wazzan, Gul Ozkan Kizilirmak, Munmun Bardhan   +2 more
wiley   +1 more source

The Major Role of Clinicians in the Discovery of Off-Label Drug Therapies [PDF]

, 2005
Objective: To determine, through a review of the medical literature and author contact, the role of clinicians in the discovery of off label use of Food and Drug Administration approved prescription drugs.
Ali, Ayfer, DeMonaco, Harold J., von Hippel, Eric A.   +2 more
core   +2 more sources

Development and validation of a fast ultra-high-performance liquid chromatography tandem mass spectrometry method for determining carbonic anhydrase inhibitors and their metabolites in urine and hair [PDF]

, 2021
A new, rapid, sensitive, and comprehensive ultra-high-performance liquid chromatography tandem mass spectrometry (UHPLC–MS/MS) method for quantifying diuretics (acetazolamide, brinzolamide, dorzolamide, and their metabolites) in human urine and hair was ...
Alfredo Fabrizio Lo Faro, Anastasio Tini, Ascanio Sirignano, Filippo Pirani, Francesco Paolo Busardò, Massimo Gottardi, Raffaele Giorgetti   +6 more
core   +1 more source

Novel Sulfonylhydrazones With Sulfonate Ester Framework: Promising Dual Inhibitors of AChE and hCAs

Biotechnology and Applied Biochemistry, Volume 72, Issue 6, Page 1752-1762, December 2025.
ABSTRACT Alzheimer's disease (AD) is a progressive neurodegenerative disorder that affects millions of individuals worldwide. Treatment strategies for AD vary depending on cognitive and behavioral symptoms, with cholinergic replacement therapy using acetylcholinesterase (AChE) inhibitors being one of the primary approaches.
Cansu Öztürk, Neslihan Balci, Osman Nuri Aslan, Erbay Kalay   +3 more
wiley   +1 more source

Evolving Real‐World Data and Evidence Use for New Drugs and Regenerative Medical Products Approvals in Japan—An Analysis of the 6‐Year Trend

Clinical Pharmacology &Therapeutics, Volume 118, Issue 6, Page 1405-1421, December 2025.
Several regulatory initiatives have been made to clarify the acceptability and requirements of real‐world data and real‐world evidence (RWD/E) for the benefit/risk assessment of new medical products in Japan. The objectives of this review were to characterize the use of RWD/E in regulatory applications of new medical products and to describe the ...
Suguru Okami, Kako Shimotsumagari, Yasunari Sadatsuki   +2 more
wiley   +1 more source