Results 1 to 10 of about 674,558 (235)

5-(Sulfamoyl)thien-2-yl 1,3-oxazole inhibitors of carbonic anhydrase II with hydrophilic periphery [PDF]

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
Hydrophilic derivatives of an earlier described series of carbonic anhydrase inhibitors have been designed, prepared and profiled against a panel of carbonic anhydrase isoforms, including the glaucoma-related hCA II.
Stanislav Kalinin, Alexander Kovalenko, Annika Valtari, Alessio Nocentini, Maxim Gureev, Arto Urtti, Mikhail Korsakov, Claudiu T. Supuran, Mikhail Krasavin   +8 more
doaj   +2 more sources

Capsaicin: A Potent Inhibitor of Carbonic Anhydrase Isoenzymes

Molecules, 2014
Carbonic anhydrase (CA, EC 4.2.1.1) is a zinc containing metalloenzyme that catalyzes the rapid and reversible conversion of carbon dioxide (CO2) and water (H2O) into a proton (H+) and bicarbonate (HCO3–) ion.
Betul Arabaci, Ilhami Gulcin, Saleh Alwasel   +2 more
doaj   +3 more sources

Aspirin: A Suicide Inhibitor of Carbonic Anhydrase II

Biomolecules, 2020
Carbonic anhydrase II (CAII) is a metalloenzyme that catalyzes the reversible hydration/dehydration of CO2/HCO3−. In addition, CAII is attributed to other catalytic reactions, including esterase activity. Aspirin (acetyl-salicylic acid), an everyday over-
Jacob Andring, Jacob Combs, Robert McKenna   +2 more
doaj   +3 more sources

Collateral Changes in Cell Physiology Associated with ADC-7 β-Lactamase Expression in Acinetobacter baumannii

Microbiology Spectrum, 2023
The ADC (AmpC) β-lactamase is universally present in the Acinetobacter baumannii chromosome, suggesting it may have a yet-to-be-identified cellular function. Using peptidoglycan composition analysis, we show that overexpressing the ADC-7 β-lactamase in A.
Jennifer M. Colquhoun, Marjan Farokhyfar, Alexander C. Anderson, Christopher R. Bethel, Robert A. Bonomo, Anthony J. Clarke, Philip N. Rather   +6 more
doaj   +1 more source

Alpha Carbonic Anhydrase 5 Mediates Stimulation of ATP Synthesis by Bicarbonate in Isolated Arabidopsis Thylakoids

Frontiers in Plant Science, 2021
We studied bicarbonate-induced stimulation of photophosphorylation in thylakoids isolated from leaves of Arabidopsis thaliana plants. This stimulation was not observed in thylakoids of wild-type in the presence of mafenide, a soluble carbonic anhydrase ...
Tatiana P. Fedorchuk, Inga A. Kireeva, Vera K. Opanasenko, Vasily V. Terentyev, Natalia N. Rudenko, Maria M. Borisova-Mubarakshina, Boris N. Ivanov   +6 more
doaj   +1 more source

Design and synthesis of some new benzoylthioureido phenyl derivatives targeting carbonic anhydrase enzymes

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
The present study aimed to develop potent carbonic anhydrase inhibitors (CAIs). The design of the target compounds was based on modifying the structure of the ureido-based carbonic anhydrase inhibitor SLC-0111.
Mazin A. A. Najm, Walaa R. Mahmoud, Azza T. Taher, Safinaz E-S. Abbas, Fadi M. Awadallah, Heba Abdelrasheed Allam, Daniela Vullo, Claudiu T. Supuran   +7 more
doaj   +1 more source

Carbon sink of microalgae in karst lakes under the influence of the extracellular of carbonic anhydrase

Carsologica Sinica, 2022
Carbonic anhydrase is a metal enzyme which contains Zn. It has the characteristics of catalyzing the mutual conversion between CO2 and HCO3− with high efficiency and specificity.
Haitao LI, Yanyou WU, Bing FU
doaj   +1 more source

Carbonic anhydrase inhibitors in patients with respiratory failure and metabolic alkalosis: a systematic review and meta-analysis of randomized controlled trials

Critical Care, 2018
Background Metabolic alkalosis is common in patients with respiratory failure and may delay weaning in mechanically ventilated patients. Carbonic anhydrase inhibitors block renal bicarbonate reabsorption, and thus reverse metabolic alkalosis.
Bassem Y Tanios, Maryam O Omran, Carlos Noujeim, Tamara Lotfi, Samir S Mallat, Pierre K Bou-Khalil, Elie A Akl, Houssam S Itani   +7 more
doaj   +1 more source

Metabolic Effect of Estrogen Receptor Agonists on Breast Cancer Cells in the Presence or Absence of Carbonic Anhydrase Inhibitors

Metabolites, 2016
Metabolic shift is one of the major hallmarks of cancer development. Estrogen receptor (ER) activity has a profound effect on breast cancer cell growth through a number of metabolic changes driven by its effect on transcription of several enzymes ...
Anissa Belkaid, Miroslava Čuperlović-Culf, Mohamed Touaibia, Rodney J. Ouellette, Marc E. Surette   +4 more
doaj   +1 more source

Ureidobenzenesulfonamides as Selective Carbonic Anhydrase I, IX, and XII Inhibitors

Molecules, 2023
Sulfonamides remain an important class of drugs, especially because of their inhibitory effects on carbonic anhydrases. Herein, we have synthesized several sulfonamides and tested them for their inhibitory activity against carbonic anhydrases hCA I, hCA ...
Toni C. Denner, Andrea Angeli, Marta Ferraroni, Claudiu T. Supuran, René Csuk   +4 more
doaj   +1 more source