Results 31 to 40 of about 47,659 (268)

Hypoxia helps glioma to fight therapy [PDF]

, 2009
Despite major improvements in the surgical management the prognosis for patients bearing malignant gliomas is still dismal. Malignant gliomas are notoriously resistant to treatment and the survival time of patients is between 3-8 years for low-grade and
Amberger-Murphy, Verena
core   +1 more source

Bottom‐Up Coacervate‐Based Artificial Cells: Integrating Cellular Hallmarks into Complex Life‐Like Systems

Angewandte Chemie, EarlyView.
Current interest in artificial cell research underscores its potential to deepen our understanding of life's fundamental processes. This review highlights advances in bottom‐up coacervate‐based artificial cell engineering via combined integration of cellular hallmarks.
Arjan Hazegh Nikroo, Angshuman Das, Madelief A. M. Verwiel, Jan C. M. van Hest   +3 more
wiley   +2 more sources

First episode psychotic disorder possibly associated with acetazolamide in a male adolescent with congenital glaucoma [PDF]

Düşünen Adam Psikiyatri ve Nörolojik Bilimler Dergisi, 2015
Primer congenital glaucoma is an uncommon ophthalmological disease manifesting at birth and accounting for 0.01-0.04% of total blindness. Acetozalamide, a carbonic anhydrase inhibitor is one of the options in the medical treatment of glaucoma and acute ...
ozhan yalcin
doaj  

Design, synthesis and biological activity of selective hCAs inhibitors based on 2-(benzylsulfinyl)benzoic acid scaffold [PDF]

, 2019
A large library of derivatives based on the scaffold of 2-(benzylsulfinyl)benzoic acid were synthesised and tested as atypical inhibitors against four different isoforms of human carbonic anhydrase (hCA I, II, IX and XII, EC 4.2.1.1).
Akdemir, A., Amoroso, R., Angeli, A., Carradori, S., Cirilli, R., De Filippis, B., De Monte, C., Guglielmi, P., Maccallini, C., Rotondi, G., Secci, D., Supuran, C. T.   +11 more
core   +2 more sources

Purification of a fragment obtained by autolysis of a PIIIb-SVMP from Bothrops alternatus venom [PDF]

, 2018
Snake Venom Metalloproteinases (SVMPs) represent 43.1% of the components in Bothrops alternatus venom and play an important role in envenomation. Disintegrins and disintegrin-like domains are released by proteolytic processing of PII and PIII classes of ...
Acosta, Ofelia Cristina, Biscoglio, Mirtha Josefa, Bustillo, Soledad, dos Santos, Patty Karina, Gay, Claudia Carolina, Leiva, Laura Cristina Ana, Olivera Moritz, Milene Nobrega de, Rodríguez, Juan Pablo, Sobreiro Selistre de Araujo, Heloisa, Van de Velde, Andrea Carolina   +9 more
core   +1 more source

Stereochemistry matters: Inhibition of carbonic anhydrase II by amino acid derived sulfamates depends on their absolute configuration

European Journal of Medicinal Chemistry Reports
Aminoalcohols were converted into the corresponding enantiomeric phenylsulfonamide sulfamates. These compounds proved to be inhibitors of carbonic anhydrase II.
Toni C. Denner, Elsa L. Klett, Niels V. Heise, René Csuk   +3 more
doaj   +1 more source

The inhibitory Effect of Acetazoleamide on Indomethacin-induced Gastric Ulcer in Guinea Pig [PDF]

Acta Medica Iranica, 1970
Experimental acute gastric ulcer is produced by the intraperitoneal injection of a single dose of indomethacin. Acetazoleamide, a potent carbonic anhydrase inhibitor, has significantly prevented the occurrence of these ulcers.
B. Djahanguiri
doaj   +1 more source

Targeting carbonic anhydrase IX and XII isoforms with small molecule inhibitors and monoclonal antibodies

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
Carbonic anhydrases IX and CAXII (CAIX/CAXII) are transmembrane zinc metalloproteins that catalyze a very basic but crucial physiological reaction: the conversion of carbon dioxide into bicarbonate with a release of the proton.
Mateusz Kciuk, Adrianna Gielecińska, Somdutt Mujwar, Mariusz Mojzych, Beata Marciniak, Rafał Drozda, Renata Kontek   +6 more
doaj   +1 more source

Mitochondrial proteomic profiling reveals increased carbonic anhydrase II in aging and neurodegeneration [PDF]

, 2016
Carbonic anhydrase inhibitors are used to treat glaucoma and cancers. Carbonic anhydrases perform a crucial role in the conversion of carbon dioxide and water into bicarbonate and protons.
Beal, Burkhard, Béchet, Chakrabarti, Corvin, Crowston, Edsall, Farrer, Fliegel, Fox, Ganie, Greenwald, Griffiths, Hansson, Hoyer, Hu, Izzotti, Jackson, Jacobson, Kassab, La Spada, La Spada, La Spada, Larsson, Levine, MacCoss, Masereel, Munnich, Nehrke, Ohlendieck, Ohlendieck, Perreault, Protasi, Rostagno, Schrattenholz, Serrano, Setou, Song, Stiernagle, Supuran, Supuran, Swenson, Swietach, Vieta, Worrall, Zhou   +45 more
core   +2 more sources

Repurposing FDA-approved sulphonamide carbonic anhydrase inhibitors for treatment of Neisseria gonorrhoeae

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
Neisseria gonorrhoeae is a high-priority pathogen of concern due to the growing prevalence of resistance development against approved antibiotics. Herein, we report the anti-gonococcal activity of ethoxzolamide, the FDA-approved human carbonic anhydrase ...
Nader S. Abutaleb, Ahmed E. M. Elhassanny, Alessio Nocentini, Chad S. Hewitt, Ahmed Elkashif, Bruce R. Cooper, Claudiu T. Supuran, Mohamed N. Seleem, Daniel P. Flaherty   +8 more
doaj   +1 more source