Results 31 to 40 of about 25,630 (237)
Angewandte Chemie, EarlyView.A new class of “super‐strained” spiro heterocycles—spirocyclic 1‐azabicyclo[1.1.0]butanes—was synthesized via insertion of cyclobutane‐, oxetane‐, and azetidine‐containing sulfonium reagents into substituted azirines. The stability of this new class of compounds was studied.
Philipp Natho +9 more
wiley +2 more sources
The inhibitory Effect of Acetazoleamide on Indomethacin-induced Gastric Ulcer in Guinea Pig [PDF]
Acta Medica Iranica, 1970 Experimental acute gastric ulcer is produced by the intraperitoneal injection of a single dose of indomethacin. Acetazoleamide, a potent carbonic anhydrase inhibitor, has significantly prevented the occurrence of these ulcers.
B. Djahanguiri
doaj +1 more source
Journal of Enzyme Inhibition and Medicinal Chemistry, 2022 Carbonic anhydrases IX and CAXII (CAIX/CAXII) are transmembrane zinc metalloproteins that catalyze a very basic but crucial physiological reaction: the conversion of carbon dioxide into bicarbonate with a release of the proton.
Mateusz Kciuk +6 more
doaj +1 more source
Journal of Enzyme Inhibition and Medicinal Chemistry, 2022 Neisseria gonorrhoeae is a high-priority pathogen of concern due to the growing prevalence of resistance development against approved antibiotics. Herein, we report the anti-gonococcal activity of ethoxzolamide, the FDA-approved human carbonic anhydrase ...
Nader S. Abutaleb +8 more
doaj +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Introduction Glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) have demonstrated significant weight‐reducing effects and may offer benefits in idiopathic intracranial hypertension (IIH); however, recent concerns about the risk of non‐arteritic anterior ischemic optic neuropathy (NAION) have emerged.
Faisal A. Al‐Harbi +9 more
wiley +1 more source
Inhibition of α1E Ca2+ Channels by Carbonic Anhydrase Inhibitors
Journal of Pharmacological Sciences, 2004 We examined if a range of carbonic anhydrase inhibitors (CAIs) interacted with the high-voltage activated voltage-sensitive calcium channels (VSCCs) encoded by the human α1E subunit.
Nicolle C.L. McNaughton +2 more
doaj +1 more source
Results in Chemistry, 2023 Inhibition of human carbonic anhydrase (hCA) enzymes is a bright target since these isoenzymes take part in various physiological events and inhibitors of these enzymes are potent drug candidates for several diseases.
Ali Atasever
doaj +1 more source
Eutectozymes as Soft Hybrid Materials for Advanced Biocatalysis
Advanced Materials, EarlyView.Eutectozymes are sustainable hybrid materials that embed a GOx–HRP cascade within hydrophobic eutectogels featuring a dual supramolecular–covalent network. This architecture preserves native enzyme structure and stability, enables efficient heterogeneous biocatalysis in aqueous media, and positions eutectogels as robust platforms for next‐generation ...
Manuel Eduardo Martinez Cartagena +10 more
wiley +1 more source
Sains NaturalThis article explores the interaction of Coumarin compounds and their derivatives obtained from natural extracts with Carbonic anhydrase II protein in inhibiting Glaucoma computationally.
Rismi Verawati +2 more
doaj +1 more source