Results 21 to 30 of about 25,630 (237)

Mechanisms of carbon dioxide detection in the earthworm Dendrobaena veneta

Frontiers in Ecology and Evolution, 2023
IntroductionCarbon dioxide (CO2) is a critical biological signal that is noxious to many animals at high concentrations. The earthworm Dendrobaena veneta lives in subterranean burrows containing high levels of CO2 and respires through its skin.
Emily Jordan Smith, Emily Jordan Smith, Jennifer L. Ryan, Sofia A. Lopresti, Dastan B. S. Haghnazari, Karleigh A. S. Anderson, Sarah J. Lipson, Erik C. Johnson, Wayne L. Silver, Cecil J. Saunders, Cecil J. Saunders   +10 more
doaj   +1 more source

Nanoarchitectonics and Molecular Docking of 4-(Dimethylamino)Pyridin-1-Ium 2-3 Methyl-4-Oxo-Pyri-Do[1,2-a]Pyrimidine-3-Carboxylate

Crystals, 2023
A retro-Claisen reaction of 1-(4-oxo-4H-pyrido [1,2-a]pyrimidin-3-yl)butane-1,3-dione, 3, in the presence of potassium hydroxide and 4-dimethylamino-pyridine has been carried out, leading to 4-(dimethylamino)pyridin-1-ium 2-methyl-4-oxo-pyrido [1,2-a ...
Sanae Lahmidi, El Hassane Anouar, Walid Ettahiri, Mohamed El Hafi, Fatima Lazrak, Mohammed M. Alanazi, Ashwag S. Alanazi, Mohamed Hefnawy, El Mokhtar Essassi, Joel T. Mague   +9 more
doaj   +1 more source

Carbonic anhydrase inhibitors: an editorial [PDF]

Expert Opinion on Therapeutic Patents, 2013
This issue of Expert Opinion on Therapeutic Patents is dedicated to carbonic anhydrase (CA, EC 4.2.1.1) inhibitors (CAIs), a highly dynamic research topic in the last years. Several review articles and patent analyses on diuretics and antiglaucoma, antiepileptic, anti-obesity and anticancer agents belonging to the pharmacological class of the CAIs are ...
openaire   +2 more sources

Inhibitory effects of sulfenimides on human and bovine carbonic anhydrase enzymes

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
A series of sulfenimide derivatives (1a-i) were investigated as inhibitors of human (hCA-I, hCA-II) and bovine (bCA) carbonic anhydrase enzymes. The compounds were synthesised by the reaction of substituted thiophenols with phthalimide by means of an ...
Hasan Yakan, Gürkan Bilir, Şükriye Çakmak, Ömer Taş, Nalan Türköz Karakullukçu, Ercan Soydan, Halil Kütük, Coşkun Güçlü, Murat Şentürk, Tayfun Arslan, Seyhan Öztürk, Ercüment Aksakal, Deniz Ekinci   +12 more
doaj   +1 more source

The effects of cardiac drugs on human erythrocyte carbonic anhydrase I and II isozymes

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
Cardiovascular diseases are the leading cause of mortality worldwide. In recent years, the relationship between carbonic anhydrase inhibitors and atherosclerosis has attracted attention.
Onur Argan, Kübra Çıkrıkçı, Aybike Baltacı, Nahit Gencer   +3 more
doaj   +1 more source

Quinazolinones as Competitive Inhibitors of Carbonic Anhydrase-II (Human and Bovine): Synthesis, in-vitro, in-silico, Selectivity, and Kinetics Studies

Frontiers in Chemistry, 2020
Carbonic anhydrase-II (CA-II) is associated with glaucoma, malignant brain tumors, and renal, gastric, and pancreatic carcinomas and is mainly involved in the regulation of the bicarbonate concentration in the eyes. CA-II inhibitors can be used to reduce
Ajmal Khan, Majid Khan, Majid Khan, Sobia Ahsan Halim, Zulfiqar Ali Khan, Zahid Shafiq, Ahmed Al-Harrasi   +6 more
doaj   +1 more source

Synthesis, molecular modelling and QSAR study of new N-phenylacetamide-2-oxoindole benzensulfonamide conjugates as carbonic anhydrase inhibitors with antiproliferative activity

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
In continuation of our previous studies to optimise potent carbonic anhydrase inhibitors, two new series of isatin N-phenylacetamide based sulphonamides were synthesised and screened for their human (h) carbonic anhydrase (EC 4.2.1.1) inhibitory ...
Mona F. Said, Riham F. George, Andrea Petreni, Claudiu T. Supuran, Nada M. Mohamed   +4 more
doaj   +1 more source

First episode psychotic disorder possibly associated with acetazolamide in a male adolescent with congenital glaucoma [PDF]

Düşünen Adam Psikiyatri ve Nörolojik Bilimler Dergisi, 2015
Primer congenital glaucoma is an uncommon ophthalmological disease manifesting at birth and accounting for 0.01-0.04% of total blindness. Acetozalamide, a carbonic anhydrase inhibitor is one of the options in the medical treatment of glaucoma and acute ...
ozhan yalcin
doaj  

Beyond Canonical CO Oxidation: Structural and Evolutionary Insights Into a Non‐Canonical Carbon Monoxide Dehydrogenase

Angewandte Chemie, EarlyView.
Clade B carbon monoxide dehydrogenases (CODHs) remain enigmatic, diverging from canonical CODHs in structure and function. Here, we present the first characterization of Ruminococcus flavefaciens CODH (RfCODH), revealing occluded substrate pathways and attenuated CO oxidation activity.
Maximilian Böhm, Vivek Srinivas, Benjamin Wiseman, Ping Huang, Moritz Senger, Martin Högbom, Henrik Land   +6 more
wiley   +2 more sources

Stereochemistry matters: Inhibition of carbonic anhydrase II by amino acid derived sulfamates depends on their absolute configuration

European Journal of Medicinal Chemistry Reports
Aminoalcohols were converted into the corresponding enantiomeric phenylsulfonamide sulfamates. These compounds proved to be inhibitors of carbonic anhydrase II.
Toni C. Denner, Elsa L. Klett, Niels V. Heise, René Csuk   +3 more
doaj   +1 more source