Frontiers in Pharmacology, 2018 Novel ocular drug delivery systems (NODDSs) remain to be explored to overcome the anatomical and physiological barriers of the eyes. This study was to encapsulate brinzolamide (BRZ)-hydropropyl-β-cyclodextrin (HP-β-CD) inclusion complex (HP-β-CD/BRZ ...
Fazhan Wang, Yongmei Liu, Chunling Jiang
exaly +3 more sources
Whiter and Greener RP-HPLC Method for Simultaneous Determination of Dorzolamide, Brinzolamide, and Timolol Using Isopropanol as a Sustainable Organic Solvent in the Mobile Phase [PDF]
SeparationsA sustainable reversed-phase chromatographic method has been developed and validated for the simultaneous determination of three active pharmaceutical ingredients, dorzolamide, brinzolamide, and timolol, used to treat glaucoma.
Sami El Deeb +2 more
doaj +3 more sources
Brinzolamide/Brimonidine Fixed Combination: Simplifying Glaucoma Treatment Regimens [PDF]
Ophthalmology and Therapy, 2018 Introduction To simplify the medical treatment of glaucoma for patients on multiple drops by introducing brinzolamide/brimonidine tartrate fixed combination (BBFC) ophthalmic suspension 1%/0.2% (SIMBRINZA®; Alcon Laboratories, Inc., Fort Worth, TX, USA ...
Reza Moosavi, Ejaz Ansari
doaj +4 more sources
Design, Synthesis and Evaluation of Novel Molecular Hybrids between Antiglaucoma Drugs and H2S Donors [PDF]
, 2022 Glaucoma is a group of eye diseases consisting of optic nerve damage with corresponding loss of field vision and blindness. Hydrogen sulfide (H2S) is a gaseous neurotransmitter implicated in various pathophysiological processes.
Andreozzi, Giorgia +13 more
core +1 more source
Brinzolamide-induced Follicular Conjunctivitis [PDF]
Journal of Glaucoma, 2018 We report a case of a patient who developed a severe case of follicular conjunctivitis from brinzolamide after 1.5 years of consistent use. This patient was rechallenged again after resolution of the follicles and subsequently redeveloped similar conjunctivitis.
Hana L. Takusagawa +3 more
openaire +3 more sources
Biology, 2022 Carbonic anhydrase inhibitors (CAIs) are prescription drugs also used in doping to dilute urine samples and tamper with urinalyses. Dorzolamide, brinzolamide, and acetazolamide are prohibited by the World Anti-Doping Agency.
Alfredo Fabrizio Lo Faro +15 more
doaj +1 more source
Topical brinzolamide and metabolic acidosis [PDF]
British Journal of Ophthalmology, 2006 Treatment of ophthalmic disease largely involves the administration of topical medication in doses that would appear small relative to those used systemically. With a few exceptions (such as β receptor antagonists) the systemic side effects of topical ocular medication, though recognised, are often ignored in clinical practice.
S A Vernon, G J Menon
openaire +2 more sources
Comparative efficacy of fixed dose combination of brinzolamide 1% and timolol 0.5% without versus with benzalkonium chloride following single ocular instillation in New Zealand white rabbits [PDF]
, 2023 Background: Benzalkonium chloride (BAK) is the most used preservative in topical ophthalmic formulations. BAK causes dry eye and trabecular meshwork degeneration. Hence, BAK-free formulations are desirable for chronic conditions like glaucoma.
Burade, Vinod +4 more
core +2 more sources
Randomized Trial of Brinzolamide/Brimonidine Versus Brinzolamide Plus Brimonidine for Open-Angle Glaucoma or Ocular Hypertension [PDF]
Advances in Therapy, 2014 Fixed-combination intraocular pressure (IOP)-lowering medications simplify treatment regimens for patients requiring 2 ocular hypotensive agents to maintain sufficiently low IOP. The aim of this study was to evaluate the safety and efficacy of fixed-combination brinzolamide 1%/brimonidine 0.2% (BBFC) versus concomitant administration of brinzolamide 1%
GANDOLFI, Stefano +4 more
openaire +3 more sources
Effects of brinzolamide on ocular haemodynamics in healthy volunteers [PDF]
British Journal of Ophthalmology, 2004 A prospective, randomised study to evaluate effects of brinzolamide on ocular haemodynamics in healthy volunteers.30 volunteers (12 men, 18 women; 28.3 (SD 7.8) years) were prospectively randomised to either brinzolamide or placebo during a 2 week double masked treatment trial.
M. Kaup +4 more
openaire +3 more sources