Results 81 to 90 of about 1,511 (168)
Brinzolamide-Loaded Nanoemulsions: In vitro Release Evaluation [PDF]
, 2022 The aim of this investigation was to design and develop nanoemulsions (NEs) as novel ophthalmic delivery systems for brinzolamide (BZD). Phase behavior of quaternary systems composed of triacetin and CapryolTM 90 (selected oils, screened through the ...
Mohammad Mehdi Mahboobian +2 more
core +1 more source
American Journal of Medical Genetics Part A, Volume 194, Issue 10, October 2024.Abstract Primary congenital glaucoma (PCG) is one of the leading causes of visual damage and blindness, severely affecting the quality of life of affected children. It is characterized by cupping of the optic disc and loss of ganglion cells due to elevated intraocular pressure. While most PCG patients exhibit epiphora, photophobia, and buphthalmos with
Oscar Francisco Chacon‐Camacho +13 more
wiley +1 more source
Clinical Ophthalmology, 2012 Graham Anthony Auger, Mathew Raynor, Simon LongstaffOphthalmology Department, Royal Hallamshire Hospital, Sheffield, South Yorkshire, United KingdomBackground: This study aimed to determine the impact of switching patients requiring multiple drug ...
Auger GA, Raynor M, Longstaff S
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Veterinary Ophthalmology, Volume 27, Issue 5, Page 406-413, September 2024.Abstract Objective To investigate ocular factors that influence the development of corneal calcareous degeneration (CCD) in dogs. Animals and Procedures The medical records of 96 eyes of dogs with CCD and 288 eyes without CCD were retrospectively reviewed. Dogs with evidence of causative systemic illness associated with CCD were excluded from the study.
Dajeong Jeong +3 more
wiley +1 more source
Synthesis and biological studies of pyrimidine derivatives targeting metabolic enzymes
Archiv der Pharmazie, Volume 357, Issue 8, August 2024.Novel synthesized pyrimidine derivatives were investigated against carbonic anhydrase isoenzymes I and II, acetylcholinesterase, butyrylcholinesterase, α‐glycosidase, and aldol reductase enzymes. The novel pyrimidine derivatives were found to have effective inhibition abilities towards the metabolic enzymes, and their modes of inhibition were evaluated.
Elif Korkusuz +7 more
wiley +1 more source
A Comparative Study of Drug Affinities Determined by Thermofluor and Kinetic Analysis [PDF]
, 2020 Determining the binding affinity and potency in vitro is one of the significant steps that can give a clue for a new candidate drug during the drug discovery process.
Shatnawi, Oruba
core +1 more source
Efficacy and safety of travoprost alone or in combination with other agents for glaucoma and ocular hypertension: patient considerations [PDF]
, 2010 Travoprost is a prostaglandin analog used in the management of glaucoma and ocular hypertension for reducing intraocular pressure (IOP). The IOP-lowering efficacy of travoprost has been shown to be similar to that of other prostaglandins, including ...
Suzuki, Cibele Lima Belico +1 more
core +3 more sources
A review on polymers in ocular drug delivery systems
MedComm – Biomaterials and Applications, Volume 3, Issue 2, June 2024.Polymers play a pivotal role in ocular drug delivery, revolutionizing treatment approaches. These biomaterials enable controlled and sustained drug release at the targeted site, enhancing bioavailability and patient compliance. From nanosized particle‐based formulations to in situ gelation mechanisms, polymers offer improved treatment options for a ...
Amol C. Bisen +10 more
wiley +1 more source
Efficacy, safety and tolerability of combination therapy with timolol and dorzolamide in glaucoma and ocular hypertension [PDF]
, 2010 Combination pharmacotherapy has simplified and improved glaucoma medication regimens. This update focuses on the previous and recent studies on efficacy and tolerability profile of dorzolamide–timolol in adult ocular hypertension and open angle glaucoma ...
Ichhpujani, Parul, Katz, L Jay
core +2 more sources
Good functional recovery following intervention for delayed suprachoroidal haemorrhage post bleb needling: a case report [PDF]
, 2008 Introduction Bleb needling is a recognised procedure in the management of patients with failing trabeculectomies. Suprachoroidal haemorrhage can occur as an unusual complication.
Cannon, Paul S +2 more
core +3 more sources