Results 121 to 130 of about 16,667 (304)

Dynamic Analysis of Brush-Seal Bristles Using an Incremental Corotational Beam and a Stick–Slip Friction Model

Lubricants
The dynamic behavior of brush-seal bristles governs seal performance and life. Brush-seal hysteresis and the contact and friction of the bristles have been studied extensively by experiments, by three-dimensional finite-element analysis, and more ...
Jae-Hyung Kim, Syed Muntazir Mehdi, Young Cheol Kim   +2 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Nutritive value and production of yellow bristle grass in Waikato dairy pastures: validating a Farmax model

, 2019
Yellow bristle grass is a C4 summeractive annual weed prevalent in the upper North Island Its production and nutritive value was assessed onfarm to validate the assumptions used in a published Farmax model on the impact of yellow bristle grass The ...
Catherine Cameron (15399053), Rose Greenfield (15398558), Chris Glassey (15399050), Katherine Tozer (15393824)   +3 more
core  

The action of mitomycin C on the bristle-forming apparatus ofPhormia regina.

, 1976
Mitomycin C, a known inhibitor of DNA synthesis, was injected into white prepupae ofPhormia regina, Adults which developed from these prepupae showed alterations of the bristle pattern, loss of whole bristle organs, and the formation of bristles without ...
Schaerer HR
core   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

CFD numerical simulation, verification with experimental results and internal flow analysis of bristle turbines

Case Studies in Thermal Engineering
In industrial facilities, a considerable amount of waste heat is often generated. However, due to the high costs associated with traditional methods of recovery, which do not align with the economic interests of enterprises, this waste heat is frequently
Sun Sheng Yang, Dong Ya Li, David Kupka, Jan Kolonicny, Punit Singh   +4 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

The Genetic Architecture of Drosophila Sensory Bristle Number

, 2002
Quantitative traits vary continuously in populations due to the segregation of multiple loci (QTL, or quantitative trait loci) and sensitivity to environmental variation.
Dilda, Christy Lynn
core  

Advanced Computational Investigation of Brush Seal Thermo-Fluid–Mechanical Performance Through Novel Porous Media Coefficient Derivation

Computation
Brush seals represent the most effective sealing technology, offering 5 to 10 times lower leakage flow rates, resulting in an 80% to 90% increase in sealing efficiency.
Altyib Abdallah Mahmoud Ahmed, Juan Wang, Meihong Liu, Aboubaker I. B. Idriss, Abdelgalal O. I. Abaker   +4 more
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source