Results 101 to 110 of about 16,667 (304)
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Smaller is better: nanobodies meet NMR
FEBS Letters, EarlyView.Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley +1 more source
, 2018 Robustness is the invariance of a given phenotype when faced with a given incoming genetic or environmental variation. Such essential property is being studied in a wide diversity of traits in many organisms but it is difficult to compare the results ...
T. Tully +2 more
core +1 more source
Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
FEBS Letters, EarlyView.What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley +1 more source
Design and Application of Rotary Bristle Brush for Peening Processes
, 2006 In this thesis, a rotary bristle tool comprised of filaments with spherical tips was designed for performing peening processes. The concept of this tool was based on simulating a single impact of the shot peening process with a single impact from a ...
Wojnar, Nicholas E.
core
Numerical simulation of 3D bristle bending in brush seals
, 2020 This paper presents a new method for predicting the 3D bending behaviour of bristles in brush seals. The model builds upon and addresses shortcomings in an earlier 2D bending model.
Guardino, C, Chew, JW
core
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
EFFICACY OF TOOTH BRUSHES OF DIFFERENT BRISTLES DESIGN IN PLAQUE REMOVAL
Journal of University Medical & Dental College, 2015 : OBJECTIVE: To evaluate the efficacy of four different deigns of manual tooth brushes available in the market, with respect to plaque removal efficacy. MATERIALS AND METHODS: It was an interventional kind of study that was examiner blind.
Muhammad Kashif +2 more
doaj
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source