Results 121 to 130 of about 1,477,327 (311)
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Seasons in the sun: the battle for Britain, 1974-1979 [PDF]
, 2012 Seasons in the Sun is a lively and attractively written account of Britain in the mid to late 1970s, covering all the political and cultural highlights and low days that readers might expect. Paul Brighton notes that although it shouldn’t be taken as the
Brighton, Paul
core
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Eskişehir Osmangazi Üniversitesi İlahiyat Fakültesi Dergisi, 2020 Bu çalışmada Sâlim Abdüsselâm eş-Şeyhî’nin “Nazariyyetü’l-kazâi’ş-şerʻî hârice diyâri’l-İslâm te’sîlen ve tenzîlen Tatbîkât alâ baʻzı ahkâmi’t-tefrîki’l-kazâî fî Britanya” isimli kitabı tanıtılmaya ve kısaca değerlendirilmeye çalışılmıştır.
Mehmet Ali YARGI
doaj
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Science Museum Group JournalScott Anthony, Deputy Head of the Research & Public History Department at the Science Museum in London, reviews Harriet Atkinson’s book Showing Resistance: Propaganda and Modernist exhibitions in Britain, 1933–53.
Scott Anthony
doaj +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
'I Have Every Reason to Love England': Black (neo)Victorianism and Transatlantic Fluidity in Neo-Victorian Fiction [PDF]
, 2016 Within neo-Victorianism, or contemporary fiction which rewrites the Victorian age, Marie-Lousie Kohlhe has pointed out a critical “reluctance to engage head-on in cross-cultural comparisons, which seem essential in order to get fully to ...
Martín-González, Juan-José
core
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source