Results 141 to 150 of about 19,233 (265)

Effect of the Broad Autism Phenotype on Physical Activity and Weight Gain in Pregnancy

, 2012
Objectives: This study aims to provide insight on the potential role ASD-related genetic liability might have in confounding associations between prenatal maternal lifestyle variables and autism risk in subsequent Early Autism Risk Longitudinal ...
Bauer, Jessica
core  

Beyond the Outburst: Charting a New Frontier for Understanding and Treating Irritability in Autistic Adults

Autism Research, EarlyView.
ABSTRACT Irritability is a prevalent and impairing feature associated with autism, yet remains poorly understood, particularly in adults. Drawing heavily on insights translated from pediatric and transdiagnostic literatures, we propose that irritability in autistic individuals often reflects a psychophysiological stress or threat response, rooted in a ...
Hsiang‐Yuan Lin, Arthur N. Westover, Amy S. F. Lutz, Manish K. Jha   +3 more
wiley   +1 more source

Linking Brain Morphometry to Psychometric Measures and Energy‐Metabolic Biomarkers in Adults With Autism Spectrum Disorder

Autism Research, EarlyView.
ABSTRACT Autism spectrum disorder (ASD) is associated with differences in neurodevelopment and altered metabolism, yet the interplay between brain morphometry, mitochondrial and energy metabolism biomarkers, and autistic traits in adults remains poorly understood. This study investigates the link between brain structure, psychometric measures, and both
Eleonora Esposto, Kathrin Nickel, Dominique Endres, Kimon Runge, Katharina Domschke, Thomas Lange, Marco Reisert, Anke Schumann, Cinzia Niolu, Ludger Tebartz van Elst, Simon Maier   +10 more
wiley   +1 more source

Motor Disorders in Autism: From Comorbidity to Core Criterion

Autism Research, EarlyView.
ABSTRACT While repetitive movements are recognized as a diagnostic hallmark of Autism Spectrum Disorder (ASD) in frameworks such as the DSM and ICD, other motor disturbances, including gait atypicalities and postural control difficulties, have historically been overlooked or framed as secondary comorbidities.
Mohamed Jaber
wiley   +1 more source

The Unique Roles of Executive Function in Co‐Occurring Psychopathologies in Autism

Autism Research, EarlyView.
ABSTRACT Children with autism spectrum disorder (ASD) often experience co‐occurring psychiatric conditions, such as anxiety and attention‐deficit/hyperactivity disorder (ADHD), which significantly impair daily functioning. However, the underlying mechanisms linking these conditions to core ASD features remain poorly understood.
Shing‐Him Ng, Jet Leung, Keith Chun Lok Lee, Angela Man Wai Lam, Isaac Ho Wai Wong, Sze‐Mai Ng, Maciej Gabrysiak, Petrina Yau Pok Lau, Sandra Sau Man Chan, Tyler M. Moore, Kosha Ruparel, Raquel E. Gur, Ruben C. Gur, Oscar Wing Ho Wong   +13 more
wiley   +1 more source

Neuropsychological profile associated with KAT6A syndrome: Emergent genotype-phenotype trends

Orphanet Journal of Rare Diseases
Background KAT6A (Arboleda-Tham) syndrome is a Mendelian disorder of the epigenetic machinery caused by pathogenic variants in the lysine acetyltransferase 6 A (KAT6A) gene.
Rowena Ng, Allison J Kalinousky, Jacqueline Harris   +2 more
doaj   +1 more source

Functional Brain Asymmetry Reveals Heterogeneous Subtypes in Autism Spectrum Disorder

Autism Research, EarlyView.
ABSTRACT Heterogeneity is a critical factor in understanding inter‐individual brain and behavioral variability in autism spectrum disorder (ASD). Since individuals with ASD exhibit atypical communication and social interaction skills closely linked to brain lateralization, this study investigated ASD heterogeneity using an asymmetry index that captures
Chae Yeon Kim, Sunghun Kim, Bo‐yong Park   +2 more
wiley   +1 more source

ACKR1/Duffy‐null genotype testing for clozapine: A guideline developed by the UK Centre of Excellence in Regulatory Science and Innovation in Pharmacogenomics (CERSI‐PGx)

British Journal of Clinical Pharmacology, EarlyView.
Abstract Clozapine is licenced for treatment‐resistant schizophrenia and psychosis in Parkinson's disease. In the United Kingdom, there is a mandatory requirement for absolute neutrophil count (ANC) and white blood cell count (WBC) monitoring to safeguard against agranulocytosis.
Stephen Murtough, Oriella Stellakis, Daisy Mills, Blanca Bjourson, Vicky Chaplin, Dharmisha Chauhan, Bev Chipp, Marius Cotic, Jana de Villiers, Olubanké Dzahini, Frances Elmslie, Katie Evans, Shreyans Gandhi, Dyfrig A. Hughes, Huajie Jin, Daniele Panconesi, Anna Skowronska, Sanjay M. Sisodiya, Ed Silva, Vicky Stinton, Sara Stuart‐Smith, Sarah Tarrant, David Taylor, Lauren Varney, James T. R. Walters, Michelle Wood, Jessica Woodley, Cinzia Dello Russo, Munir Pirmohamed, Elvira Bramon   +29 more
wiley   +1 more source

On the importance of including both sexes in animal studies – insights from home‐cage monitoring

Biological Reviews, EarlyView.
ABSTRACT A review of behavioural studies using home‐cage monitoring (HCM) systems revealed that over 61% of studies used only male subjects, with only 24% including both sexes, despite evidence of substantial behavioural differences between male and female animals. This bias could influence the outcomes of biomedical research.
Maša Čater, Adam Dušek, Aleksandra Bartelik, Silvia Mandillo, Elisabetta Golini, Mara Rigamonti, Rasneer Sonia Bains, Hamish Forrest, Marion Rivalan, Melissa Long, Anna Kiryk, Lars Lewejohann, Nuno Henrique Franco   +12 more
wiley   +1 more source

Genomic Insights Into Risperidone Treatment Outcomes in Children and Adolescents: Experience From a Psychiatric Hospital Serving Rural Youth

Clinical Pharmacology &Therapeutics, EarlyView.
Risperidone is a commonly used antipsychotic for treating psychiatric illness in children and adolescents. There is a large variability in risperidone response and discontinuation rates remain high. Pharmacogenomics offers the opportunity to improve risperidone outcomes, yet studies in pediatric populations are limited.
Jack W. Staples, Shayna R. Killam, Karen E. Brown, Rachel Dalton, Elizabeth Sather, Qiang Chen, Joshua Loveland, Corbin Schwanke, Abdallah F. Elias, Kristin L. Bigos, Erica L. Woodahl   +10 more
wiley   +1 more source