Results 1 to 10 of about 20,797 (156)

Temporal Discrimination: Mechanisms and Relevance to Adult-Onset Dystonia [PDF]

Frontiers in Neurology, 2017
Temporal discrimination is the ability to determine that two sequential sensory stimuli are separated in time. For any individual, the temporal discrimination threshold (TDT) is the minimum interval at which paired sequential stimuli are perceived as ...
Antonella Conte, Antonella Conte, Eavan M. McGovern, Eavan M. McGovern, Shruti Narasimham, Shruti Narasimham, Shruti Narasimham, Rebecca Beck, Rebecca Beck, Rebecca Beck, Owen Killian, Owen Killian, Owen Killian, Sean O’Riordan, Sean O’Riordan, Richard B. Reilly, Richard B. Reilly, Richard B. Reilly, Michael Hutchinson, Michael Hutchinson   +19 more
doaj   +3 more sources

Endophenotype Research in Epilepsy Across Time [PDF]

Brain Sciences
Background/Objectives: Endophenotypes—quantifiable biological markers bridging genetic variations and clinical manifestations—have significantly evolved since their introduction to psychiatric genetics.
Ozgun Yetkin, Ovinuchi Ejiohuo, Betul Baykan, Marcin Zarowski   +3 more
doaj   +2 more sources

Is there an association between advanced paternal age and endophenotype deficit levels in schizophrenia? [PDF]

PLoS ONE, 2014
The children of older fathers have increased risks of developing schizophrenia spectrum disorders, and among those who develop these disorders, those with older fathers present with more severe clinical symptoms.
Debby Tsuang, Michelle Esterberg, David Braff, Monica Calkins, Kristin Cadenhead, Dorcas Dobie, Robert Freedman, Michael F Green, Tiffany Greenwood, Raquel Gur, Ruben Gur, William Horan, Laura C Lazzeroni, Gregory A Light, Steven P Millard, Ann Olincy, Keith Nuechterlein, Larry Seidman, Larry Siever, Jeremy Silverman, William Stone, Joyce Sprock, Catherine Sugar, Neal Swerdlow, Ming Tsuang, Bruce Turetsky, Allen Radant   +26 more
doaj   +7 more sources

High Dimensional Endophenotype Ranking in the Search for Major Depression Risk Genes [PDF]

Biological Psychiatry, 2012
BACKGROUND: Despite overwhelming evidence that major depression is highly heritable, recent studies have localized only a single depression-related locus reaching genome-wide significance and have yet to identify a causal gene.
David C Glahn, Joanne E Curran, Anderson M Winkler   +2 more
exaly   +2 more sources

Is decision-making impairment an endophenotype of anorexia nervosa?

European Psychiatry, 2022
Background Patients with anorexia nervosa (AN) show impaired decision-making ability, but it is still unclear if this is a trait marker (i.e., being associated with AN at any stage of the disease) or a state parameter of the disease (i.e., being present ...
Laura Di Lodovico, Audrey Versini, Mathieu Lachatre, Jacopo Marcheselli, Nicolas Ramoz, Philip Gorwood   +5 more
doaj   +3 more sources

Characterization of neurophysiologic and neurocognitive biomarkers for use in genomic and clinical outcome studies of schizophrenia. [PDF]

, 2012
BackgroundEndophenotypes are quantitative, laboratory-based measures representing intermediate links in the pathways between genetic variation and the clinical expression of a disorder.
Braff, David L, Geyer, Mark A, Light, Gregory A, Pela, Marlena, Radant, Allen, Rissling, Anthony J, Sprock, Joyce, Sugar, Catherine A, Swerdlow, Neal R   +8 more
core   +10 more sources

Genetics in the ADHD Clinic: How Can Genetic Testing Support the Current Clinical Practice?

Frontiers in Psychology, 2022
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder with a childhood prevalence of 5%. In about two-thirds of the cases, ADHD symptoms persist into adulthood and often cause significant functional impairment.
Lívia Balogh, Attila J. Pulay, János M. Réthelyi   +2 more
doaj   +1 more source

Quantitative trait locus analysis for endophenotypes reveals genetic substrates of core symptom domains and neurocognitive function in autism spectrum disorder

Translational Psychiatry, 2022
Autism spectrum disorder (ASD) represents a heterogeneous group of neurodevelopmental disorders and is largely attributable to genetic risk factors. Phenotypic and genetic heterogeneity of ASD have been well-recognized; however, genetic substrates for ...
In-Hee Lee, Ekaterina Koelliker, Sek Won Kong   +2 more
doaj   +1 more source

Slower Peak Pupillary Response to Emotional Faces in Parents of Autistic Individuals

Frontiers in Psychology, 2022
BackgroundAtypical autonomic arousal has been consistently documented in autism spectrum disorder (ASD) and is thought to contribute to the social-communication phenotype of ASD. Some evidence suggests that clinically unaffected first-degree relatives of
Abigail L. Hogan, Molly Winston, Jamie Barstein, Molly Losh   +3 more
doaj   +1 more source

Amygdala hyperreactivity to faces conditioned with a social-evaluative meaning– a multiplex, multigenerational fMRI study on social anxiety endophenotypes

NeuroImage: Clinical, 2020
Social anxiety disorder (SAD) runs in families, but the neurobiological pathways underlying the genetic susceptibility towards SAD are largely unknown. Here, we employed an endophenotype approach, and tested the hypothesis that amygdala hyperreactivity ...
Janna Marie Bas-Hoogendam, Henk van Steenbergen, Nic J.A. van der Wee, P. Michiel Westenberg   +3 more
doaj   +1 more source