Results 1 to 10 of about 4,269 (166)

Estimating genetic effect sizes under joint disease-endophenotype models in presence of gene-environment interactions [PDF]

Frontiers in Genetics, 2015
Effects of genetic variants on the risk of complex diseases estimated from association studies are typically small. Nonetheless, variants may have important effects in presence of specific levels of environmental exposures, and when a trait related to ...
Alexandre eBureau, Alexandre eBureau, Jordie eCroteau, Christian eCouture, Marie-Claude eVohl, Marie-Claude eVohl, Claude eBouchard, Louis ePérusse   +7 more
doaj   +3 more sources

Is there an association between advanced paternal age and endophenotype deficit levels in schizophrenia? [PDF]

PLoS ONE, 2014
The children of older fathers have increased risks of developing schizophrenia spectrum disorders, and among those who develop these disorders, those with older fathers present with more severe clinical symptoms.
Debby Tsuang, Michelle Esterberg, David Braff, Monica Calkins, Kristin Cadenhead, Dorcas Dobie, Robert Freedman, Michael F Green, Tiffany Greenwood, Raquel Gur, Ruben Gur, William Horan, Laura C Lazzeroni, Gregory A Light, Steven P Millard, Ann Olincy, Keith Nuechterlein, Larry Seidman, Larry Siever, Jeremy Silverman, William Stone, Joyce Sprock, Catherine Sugar, Neal Swerdlow, Ming Tsuang, Bruce Turetsky, Allen Radant   +26 more
doaj   +3 more sources

The shine-through masking paradigm is a potential endophenotype of schizophrenia. [PDF]

PLoS ONE, 2010
BACKGROUND: To understand the genetics of schizophrenia, a hunt for so-called intermediate phenotypes or endophenotypes is ongoing. Visual masking has been proposed to be such an endophenotype. However, no systematic study has been conducted yet to prove
Eka Chkonia, Maya Roinishvili, Natia Makhatadze, Lidia Tsverava, Andrea Stroux, Konrad Neumann, Michael H Herzog, Andreas Brand   +7 more
doaj   +4 more sources

Whole-brain functional hypoconnectivity as an endophenotype of autism in adolescents [PDF]

NeuroImage: Clinical, 2015
Endophenotypes are heritable and quantifiable markers that may assist in the identification of the complex genetic underpinnings of psychiatric conditions. Here we examined global hypoconnectivity as an endophenotype of autism spectrum conditions (ASCs).
R.L. Moseley, R.J.F. Ypma, R.J. Holt, D. Floris, L.R. Chura, M.D. Spencer, S. Baron-Cohen, J. Suckling, E. Bullmore, M. Rubinov   +9 more
doaj   +3 more sources

Is decision-making impairment an endophenotype of anorexia nervosa?

European Psychiatry, 2022
Background Patients with anorexia nervosa (AN) show impaired decision-making ability, but it is still unclear if this is a trait marker (i.e., being associated with AN at any stage of the disease) or a state parameter of the disease (i.e., being present ...
Laura Di Lodovico, Audrey Versini, Mathieu Lachatre, Jacopo Marcheselli, Nicolas Ramoz, Philip Gorwood   +5 more
doaj   +3 more sources

Visual masking deficits in schizophrenia: a view into the genetics of the disease through an endophenotype [PDF]

, 2022
Schizophrenia is a severe psychiatric disorder determined by a complex mixture of genetic and environmental factors. To better understand the contributions of human genetic variations to schizophrenia, we performed a genome-wide association study (GWAS ...
Roinishvili, Maya, da Cruz, Janir Ramos, Brand, Andreas, Shaqiri, Albulena, Hodel, Flavia, Fellay, Jacques, Chkonia, Eka, Herzog, Michael H.   +7 more
core   +3 more sources

Genetics in the ADHD Clinic: How Can Genetic Testing Support the Current Clinical Practice?

Frontiers in Psychology, 2022
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder with a childhood prevalence of 5%. In about two-thirds of the cases, ADHD symptoms persist into adulthood and often cause significant functional impairment.
Lívia Balogh, Attila J. Pulay, János M. Réthelyi   +2 more
doaj   +1 more source

Quantitative trait locus analysis for endophenotypes reveals genetic substrates of core symptom domains and neurocognitive function in autism spectrum disorder

Translational Psychiatry, 2022
Autism spectrum disorder (ASD) represents a heterogeneous group of neurodevelopmental disorders and is largely attributable to genetic risk factors. Phenotypic and genetic heterogeneity of ASD have been well-recognized; however, genetic substrates for ...
In-Hee Lee, Ekaterina Koelliker, Sek Won Kong   +2 more
doaj   +1 more source

Slower Peak Pupillary Response to Emotional Faces in Parents of Autistic Individuals

Frontiers in Psychology, 2022
BackgroundAtypical autonomic arousal has been consistently documented in autism spectrum disorder (ASD) and is thought to contribute to the social-communication phenotype of ASD. Some evidence suggests that clinically unaffected first-degree relatives of
Abigail L. Hogan, Molly Winston, Jamie Barstein, Molly Losh   +3 more
doaj   +1 more source

Amygdala hyperreactivity to faces conditioned with a social-evaluative meaning– a multiplex, multigenerational fMRI study on social anxiety endophenotypes

NeuroImage: Clinical, 2020
Social anxiety disorder (SAD) runs in families, but the neurobiological pathways underlying the genetic susceptibility towards SAD are largely unknown. Here, we employed an endophenotype approach, and tested the hypothesis that amygdala hyperreactivity ...
Janna Marie Bas-Hoogendam, Henk van Steenbergen, Nic J.A. van der Wee, P. Michiel Westenberg   +3 more
doaj   +1 more source