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Electrophysiological Endophenotypes for Schizophrenia [PDF]
Harvard Review of Psychiatry, 2016 Endophenotypes are quantitative, heritable traits that may help to elucidate the pathophysiologic mechanisms underlying complex disease syndromes, such as schizophrenia. They can be assessed at numerous levels of analysis; here, we review electrophysiological endophenotypes that have shown promise in helping us understand schizophrenia from a more ...
Owens, Emily M +3 more
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Identifying endophenotypes of autism: A multivariate approach
Frontiers in Computational Neuroscience, 2014 The existence of an endophenotype of autism spectrum condition (ASC) has been recently suggested by several commentators. It can be estimated by finding differences between controls and people with ASC that are also present when comparing controls and ...
Fermín eSegovia +10 more
doaj +1 more source
Subtle Cerebellar Features in Relatives of Essential Tremor Cases
Frontiers in Neurology, 2020 Background: Essential tremor (ET) cases often exhibit a range of mild cerebellar signs. Their unaffected relatives have been shown in prior studies to exhibit subtle (i.e., preclinical) disease features.Objective: To quantify subtle cerebellar signs in ...
Evan A. Hale +8 more
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Frontiers in Molecular Neuroscience, 2022 Larval zebrafish are often used to model anxiety disorders. However, since it is impossible to recapitulate the full complexity and heterogeneity of anxiety in this model, examining component endophenotypes is key to dissecting the mechanisms underlying ...
Ruey-Kuang Cheng +4 more
doaj +1 more source
Reduced Prepulse Inhibition as a Biomarker of Schizophrenia
Frontiers in Behavioral Neuroscience, 2016 The startle response is composed by a set of reflex behaviors intended to prepare the organism to face a potentially relevant stimulus. This response can be modulated by several factors as, for example, repeated presentations of the stimulus (startle ...
Luis Gonzalo De La Casa +5 more
doaj +1 more source
Low serum sphingolipids in children with attention deficit-hyperactivity disorder
Frontiers in Neuroscience, 2015 Background: Attention deficit-hyperactivity disorder (ADHD) is the most prevalent neuropsychiatric condition in childhood. ADHD is a multifactorial trait with a strong genetic component. One neurodevelopmental hypothesis is that ADHD is associated with a
Marcela Patricia Henríquez-Henríquez +6 more
doaj +1 more source
Pro-inflammatory cytokine alterations in unaffected first-degree relatives of schizophrenia patients
European Psychiatry, 2021 Introduction A growing body of evidence in both chronic and first-episode schizophrenia report increased expression of pro-inflammatory substances in the blood and cerebrospinal fluid of patients.
A. Kurtulmus
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Endophenotypes in a Dynamically Connected Brain [PDF]
Behavior Genetics, 2010 We examined the longitudinal genetic architecture of three parameters of functional brain connectivity. One parameter described overall connectivity (synchronization likelihood, SL). The two others were derived from graph theory and described local (clustering coefficient, CC) and global (average path length, L) aspects of connectivity.
Smit, D. J.A. +6 more
openaire +3 more sources
Frontiers in Psychology, 2014 Mathematics learning difficulties are a highly comorbid and heterogeneous set of disorders linked to several dissociable mechanisms and endophenotypes.
Vitor Geraldi Haase +9 more
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, 2016 Objectives: To investigate the conditions and analysis strategies required so that endophenotypes related to a disease help discover genetic variants involved in the disease.
Croteau J. (2898239) +1 more
core +1 more source