Results 21 to 30 of about 20,878 (232)
Endophenotype: a conceptual analysis [PDF]
Molecular Psychiatry, 2010 This paper provides a conceptual analysis of the endophenotype (EP) construct that is having an increasing role in genetic strategies for unraveling the etiology of psychiatric disorders (PDs). We make six major points illustrated through the method of path analysis.
K S, Kendler, M C, Neale
openaire +2 more sources
Extension of the Generalized Disequilibrium Test to polytomous phenotypes and two-locus models
Frontiers in Genetics, 2014 We extend the usual logistic model between a dichotomous phenotype and an allele count in two ways: a polytomous phenotype with K > 2 levels, and modelling of allele counts at two unlinked marker loci.
Alexandre eBureau +7 more
doaj +1 more source
Advances in endophenotyping schizophrenia [PDF]
World Psychiatry, 2008 The search for the genetic architecture of schizophrenia has employed multiple, often converging strategies. One such strategy entails the use of tracing the heritability and neurobiology of endophenotypes. Endophenotypes are quantifiable traits not visible to the eye, which are thought to reflect an intermediate place on the path from genes to ...
David L, Braff +4 more
openaire +2 more sources
The involvement of noradrenaline in rapid eye movement (REM) sleep mentation
Frontiers in Neurology, 2011 Noradrenaline, one of the main brain monoamines, has powerful central influences on neurobiological processes in the forebrain which support the mental activities occurring during the sleep–waking cycle. Noradrenergic neurons are activated during waking,
Claude eGottesmann
doaj +1 more source
Frontiers in Molecular Neuroscience, 2022 Larval zebrafish are often used to model anxiety disorders. However, since it is impossible to recapitulate the full complexity and heterogeneity of anxiety in this model, examining component endophenotypes is key to dissecting the mechanisms underlying ...
Ruey-Kuang Cheng +4 more
doaj +1 more source
Integrating cognitive (neuro)science using mechanisms [PDF]
, 2016 In this paper, an account of theoretical integration in cognitive (neuro)science from the mechanistic perspective is defended. It is argued that mechanistic patterns of integration can be better understood in terms of constraints on ...
Miłkowski, Marcin
core +3 more sources
Electrophysiological Endophenotypes for Schizophrenia [PDF]
Harvard Review of Psychiatry, 2016 Endophenotypes are quantitative, heritable traits that may help to elucidate the pathophysiologic mechanisms underlying complex disease syndromes, such as schizophrenia. They can be assessed at numerous levels of analysis; here, we review electrophysiological endophenotypes that have shown promise in helping us understand schizophrenia from a more ...
Owens, Emily M +3 more
openaire +4 more sources
Identifying endophenotypes of autism: A multivariate approach
Frontiers in Computational Neuroscience, 2014 The existence of an endophenotype of autism spectrum condition (ASC) has been recently suggested by several commentators. It can be estimated by finding differences between controls and people with ASC that are also present when comparing controls and ...
Fermín eSegovia +10 more
doaj +1 more source
The shine-through masking paradigm is a potential endophenotype of schizophrenia. [PDF]
PLoS ONE, 2010 BACKGROUND: To understand the genetics of schizophrenia, a hunt for so-called intermediate phenotypes or endophenotypes is ongoing. Visual masking has been proposed to be such an endophenotype. However, no systematic study has been conducted yet to prove
Eka Chkonia +7 more
doaj +1 more source
Subtle Cerebellar Features in Relatives of Essential Tremor Cases
Frontiers in Neurology, 2020 Background: Essential tremor (ET) cases often exhibit a range of mild cerebellar signs. Their unaffected relatives have been shown in prior studies to exhibit subtle (i.e., preclinical) disease features.Objective: To quantify subtle cerebellar signs in ...
Evan A. Hale +8 more
doaj +1 more source